BT3A1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BT3A1_HUMAN
• UniProt AC: O00481
• Protein Name: Butyrophilin subfamily 3 member A1
• Gene Name: BTN3A1
• Organism: Homo sapiens (Human).
• Sequence Length: 513
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate..
• Protein Sequence: MKMASFLAFLLLNFRVCLLLLQLLMPHSAQFSVLGPSGPILAMVGEDADLPCHLFPTMSAETMELKWVSSSLRQVVNVYADGKEVEDRQSAPYRGRTSILRDGITAGKAALRIHNVTASDSGKYLCYFQDGDFYEKALVELKVAALGSDLHVDVKGYKDGGIHLECRSTGWYPQPQIQWSNNKGENIPTVEAPVVADGVGLYAVAASVIMRGSSGEGVSCTIRSSLLGLEKTASISIADPFFRSAQRWIAALAGTLPVLLLLLGGAGYFLWQQQEEKKTQFRKKKREQELREMAWSTMKQEQSTRVKLLEELRWRSIQYASRGERHSAYNEWKKALFKPADVILDPKTANPILLVSEDQRSVQRAKEPQDLPDNPERFNWHYCVLGCESFISGRHYWEVEVGDRKEWHIGVCSKNVQRKGWVKMTPENGFWTMGLTDGNKYRTLTEPRTNLKLPKPPKKVGVFLDYETGDISFYNAVDGSHIHTFLDVSFSEALYPVFRILTLEPTALTICPA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
70	Phosphorylation	MELKWVSSSLRQVVN HHHHHHHHHHHHHHE	24.63	25954137
71	Phosphorylation	ELKWVSSSLRQVVNV HHHHHHHHHHHHHEE	21.77	25954137
83	Ubiquitination	VNVYADGKEVEDRQS HEEEECCCCCCCCCC	60.16	-
83 (in isoform 2)	Ubiquitination	-	60.16	21906983
83 (in isoform 1)	Ubiquitination	-	60.16	21906983
98	Phosphorylation	APYRGRTSILRDGIT CCCCCCCCHHHCCCC	20.47	24719451
108	Ubiquitination	RDGITAGKAALRIHN HCCCCCCCHHHEEEE	28.20	-
112	Methylation	TAGKAALRIHNVTAS CCCCHHHEEEEEECC	24.32	-
115	N-linked_Glycosylation	KAALRIHNVTASDSG CHHHEEEEEECCCCC	30.39	22846996
123	Ubiquitination	VTASDSGKYLCYFQD EECCCCCCEEEEEEC	38.71	-
155	Ubiquitination	SDLHVDVKGYKDGGI CCEEEEECEEECCCE	52.65	-
244	O-linked_Glycosylation	IADPFFRSAQRWIAA ECCHHHHHHHHHHHH	24.48	29351928
255	O-linked_Glycosylation	WIAALAGTLPVLLLL HHHHHHCHHHHHHHH	23.45	29351928
299	Ubiquitination	EMAWSTMKQEQSTRV HHHHHHHHHHHHHHH	51.26	-
316	Phosphorylation	LEELRWRSIQYASRG HHHHHHHHHHHHHCC	13.69	-
327	Phosphorylation	ASRGERHSAYNEWKK HHCCCCCHHHHHHHH	38.37	28857561
334	Ubiquitination	SAYNEWKKALFKPAD HHHHHHHHHHCCCCC	51.93	-
338	Ubiquitination	EWKKALFKPADVILD HHHHHHCCCCCEEEC	39.90	-
347	Ubiquitination	ADVILDPKTANPILL CCEEECCCCCCCEEE	60.99	-
392	Phosphorylation	LGCESFISGRHYWEV EECCCEECCCCEEEE	27.97	24719451
441	Phosphorylation	GLTDGNKYRTLTEPR CCCCCCCEECCCCCC	16.90	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BT3A1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BT3A1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BT3A1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TFF1_HUMAN	TFF1	physical	21982860

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.