AHK2_ARATH - dbPTM
AHK2_ARATH - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AHK2_ARATH
UniProt AC Q9C5U2
Protein Name Histidine kinase 2
Gene Name AHK2
Organism Arabidopsis thaliana (Mouse-ear cress).
Sequence Length 1176
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein .
Protein Description Cytokinins (CK) receptor related to bacterial two-component regulators. Functions as a histidine kinase and transmits the stress signal to a downstream MAPK cascade. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain. In the presence of cytokinin, feeds phosphate to phosphorelay-integrating histidine phosphotransfer protein (HPt) and activates subsequent cascade. Involved in meristems establishment in seedlings. Redundant negative regulator of drought and salt stress responses and abscisic acid (ABA) signaling. Together with AHK3, plays a negative regulatory role in cold stress signaling via inhibition of ABA response, occurring independently of the cold acclimation pathway. Redundant positive regulator of cytokinin signaling that regulates many developmental processes including seed germination, cell division, seed size, chlorophyll retention during leaf senescence, root repression and shoot promotion. Involved in alkamides (e.g. N-isobutyl decanamide) and N-acylethanolamides (NAE) signaling that control meristematic activity and differentiation processes during plant development. Contributes to vascular bundle formation and secondary growth in a cytokinin-dependent manner, probably by promoting the maintenance of mitotic activity and/or identity of procambial cells. Together with AHK4, required for growth and reproduction promotion stimulated by the endophytic fungus Piriformospora indica in a trans-zeatin-dependent manner. Required by the cytokinin-dependent flower development regulation pathway..
Protein Sequence MSITCELLNLTSKKAKKSSSSDKKWLKKPLFFLILCGSLVIVLVMFLRLGRSQKEETDSCNGEEKVLYRHQNVTRSEIHDLVSLFSDSDQVTSFECHKESSPGMWTNYGITCSLSVRSDKQETRGLPWNLGLGHSISSTSCMCGNLEPILQQPENLEEENHEEGLEQGLSSYLRNAWWCLILGVLVCHKIYVSHSKARGERKEKVHLQEALAPKKQQQRAQTSSRGAGRWRKNILLLGILGGVSFSVWWFWDTNEEIIMKRRETLANMCDERARVLQDQFNVSLNHVHALSILVSTFHHGKIPSAIDQRTFEEYTERTNFERPLTSGVAYALKVPHSEREKFEKEHGWAIKKMETEDQTVVQDCVPENFDPAPIQDEYAPVIFAQETVSHIVSVDMMSGEEDRENILRARASGKGVLTSPFKLLKSNHLGVVLTFAVYDTSLPPDATEEQRVEATIGYLGASYDMPSLVEKLLHQLASKQTIAVDVYDTTNTSGLIKMYGSEIGDISEQHISSLDFGDPSRNHEMHCRFKHKLPIPWTAITPSILVLVITFLVGYILYEAINRIATVEEDCQKMRELKARAEAADIAKSQFLATVSHEIRTPMNGVLGMLKMLMDTDLDAKQMDYAQTAHGSGKDLTSLINEVLDQAKIESGRLELENVPFDMRFILDNVSSLLSGKANEKGIELAVYVSSQVPDVVVGDPSRFRQIITNLVGNSIKFTQERGHIFISVHLADEVKEPLTIEDAVLKQRLALGCSESGETVSGFPAVNAWGSWKNFKTCYSTESQNSDQIKLLVTVEDTGVGIPVDAQGRIFTPFMQADSSTSRTYGGTGIGLSISKRLVELMQGEMGFVSEPGIGSTFSFTGVFGKAETNTSITKLERFDLAIQEFTGLRALVIDNRNIRAEVTRYELRRLGISADIVSSLRMACTCCISKLENLAMILIDKDAWNKEEFSVLDELFTRSKVTFTRVPKIFLLATSATLTERSEMKSTGLIDEVVIKPLRMSVLICCLQETLVNGKKRQPNRQRRNLGHLLREKQILVVDDNLVNRRVAEGALKKYGAIVTCVESGKAALAMLKPPHNFDACFMDLQMPEMDGFEATRRVRELEREINKKIASGEVSAEMFCKFSSWHVPILAMTADVIQATHEECMKCGMDGYVSKPFEEEVLYTAVARFFEPC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSITCELLN
------CCHHHHHHH		37.6019880383
597PhosphorylationQFLATVSHEIRTPMN
HHHHHHCHHCCCCCH		30.11-
740PhosphorylationDEVKEPLTIEDAVLK
CCCCCCCCHHHHHHH		32.7919880383
942PhosphorylationNLAMILIDKDAWNKE
HHEEEEECCCCCCHH		39.06-
1086PhosphorylationNFDACFMDLQMPEMD
CCCCCEECCCCCCCC		17.31-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AHK2_ARATH !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AHK2_ARATH !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AHK2_ARATH !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AHK3_ARATHHK3genetic
16361392
AHK4_ARATHWOLgenetic
16361392
AHP2_ARATHAHP2physical
18642946
AHP3_ARATHAHP3physical
18642946
HIR1_ARATHHIR1physical
18642946
PNSL5_ARATHCYP20-2physical
18642946
PRS4A_ARATHRPT2aphysical
18642946
SUI11_ARATHAT4G27130physical
18642946
NAC81_ARATHATAF2physical
18642946
VRN1_ARATHVRN1physical
18642946
NAC98_ARATHCUC2physical
18642946
CX6B1_ARATHCOX6Bphysical
18642946
DRP1A_ARATHDL1physical
18642946
FH14_ARATHAFH14physical
18642946
CP74A_ARATHAOSphysical
18642946
NA102_ARATHNAC102physical
18642946
APBLA_ARATHAT5G11490physical
18642946
2SS3_ARATHSESA3physical
18642946
P4KG5_ARATHAT1G26270physical
18642946
P4KB1_ARATHPI-4KBETA1physical
18642946
ARI8_ARATHARI8physical
18642946
GRXC3_ARATHAT1G77370physical
18642946
MDA3_ARATHAT5G42060physical
18642946
HIR2_ARATHAT1G69840physical
18642946
SOT15_ARATHST2Aphysical
18642946
AGP15_ARATHAGP15physical
18642946
AHK2_ARATHHK2physical
21709172
ARR14_ARATHRR14physical
16965536
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AHK2_ARATH

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Related Literatures of Post-Translational Modification

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