DRP1A_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DRP1A_ARATH
• UniProt AC: P42697
• Protein Name: Dynamin-related protein 1A
• Gene Name: DRP1A
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 610
• Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, phragmoplast. Microtubule-associated and localized in the forming cell plate during cytokinesis.
• Protein Description: Microtubule-associated force-producing protein that is targeted to the forming cell plate during cytokinesis. Plays also a major role in plasma membrane maintenance and cell wall integrity with implications in vesicular trafficking, polar cell expansion, vascular formation, and other aspects of plant growth and development. Has a GTPase activity..
• Protein Sequence: MENLISLVNKIQRACTALGDHGDSSALPTLWDSLPAIAVVGGQSSGKSSVLESIVGKDFLPRGSGIVTRRPLVLQLQKIDDGTREYAEFLHLPRKKFTDFAAVRKEIQDETDRETGRSKAISSVPIHLSIYSPNVVNLTLIDLPGLTKVAVDGQSDSIVKDIENMVRSYIEKPNCIILAISPANQDLATSDAIKISREVDPSGDRTFGVLTKIDLMDKGTDAVEILEGRSFKLKYPWVGVVNRSQADINKNVDMIAARKREREYFSNTTEYRHLANKMGSEHLAKMLSKHLERVIKSRIPGIQSLINKTVLELETELSRLGKPIAADAGGKLYSIMEICRLFDQIFKEHLDGVRAGGEKVYNVFDNQLPAALKRLQFDKQLAMDNIRKLVTEADGYQPHLIAPEQGYRRLIESSIVSIRGPAEASVDTVHAILKDLVHKSVNETVELKQYPALRVEVTNAAIESLDKMREGSKKATLQLVDMECSYLTVDFFRKLPQDVEKGGNPTHSIFDRYNDSYLRRIGSNVLSYVNMVCAGLRNSIPKSIVYCQVREAKRSLLDHFFAELGTMDMKRLSSLLNEDPAIMERRSAISKRLELYRAAQSEIDAVAWSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MENLISLV -------CHHHHHHH	7.51	22223895
48	Phosphorylation	GGQSSGKSSVLESIV CCCCCCCHHHHHHHH	29.24	25561503
49	Phosphorylation	GQSSGKSSVLESIVG CCCCCCHHHHHHHHC	33.92	25561503
64	Phosphorylation	KDFLPRGSGIVTRRP CCCCCCCCCCCCCCC	26.99	28011693
211	Phosphorylation	DRTFGVLTKIDLMDK CCEEEEEEEEEECCC	24.44	19880383
280	Phosphorylation	HLANKMGSEHLAKML HHHHHHCHHHHHHHH	20.53	24894044
458	Phosphorylation	PALRVEVTNAAIESL CCEEEEEHHHHHHHH	12.97	17317660
464	Phosphorylation	VTNAAIESLDKMREG EHHHHHHHHHHHHCC	35.44	17317660

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DRP1A_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DRP1A_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DRP1A_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DRP1A_ARATH	DL1	physical	19144001
AGD3_ARATH	SFC	physical	15923323
DRP1A_ARATH	DL1	physical	20231465
DRP2B_ARATH	DL3	physical	20231465

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.