ZBP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZBP1_HUMAN
• UniProt AC: Q9H171
• Protein Name: Z-DNA-binding protein 1
• Gene Name: ZBP1
• Organism: Homo sapiens (Human).
• Sequence Length: 429
• Protein Description: Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity)..
• Protein Sequence: MAQAPADPGREGHLEQRILQVLTEAGSPVKLAQLVKECQAPKRELNQVLYRMKKELKVSLTSPATWCLGGTDPEGEGPAELALSSPAERPQQHAATIPETPGPQFSQQREEDIYRFLKDNGPQRALVIAQALGMRTAKDVNRDLYRMKSRHLLDMDEQSKAWTIYRPEDSGRRAKSASIIYQHNPINMICQNGPNSWISIANSEAIQIGHGNIITRQTVSREDGSAGPRHLPSMAPGDSSTWGTLVDPWGPQDIHMEQSILRRVQLGHSNEMRLHGVPSEGPAHIPPGSPPVSATAAGPEASFEARIPSPGTHPEGEAAQRIHMKSCFLEDATIGNSNKMSISPGVAGPGGVAGSGEGEPGEDAGRRPADTQSRSHFPRDIGQPITPSHSKLTPKLETMTLGNRSHKAAEGSHYVDEASHEGSWWGGGI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	QRILQVLTEAGSPVK HHHHHHHHHCCCHHH	25.57	29978859
27	Phosphorylation	QVLTEAGSPVKLAQL HHHHHCCCHHHHHHH	33.30	29978859
148	Acetylation	NRDLYRMKSRHLLDM CHHHHHHHHHHCCCC	35.03	7683469
159	Phosphorylation	LLDMDEQSKAWTIYR CCCCCCCCCCEEEEC	23.46	-
165	Phosphorylation	QSKAWTIYRPEDSGR CCCCEEEECCCCCCC	16.85	-
259	Phosphorylation	QDIHMEQSILRRVQL CCCCHHHHHHHHHHC	15.41	24719451
279	Phosphorylation	MRLHGVPSEGPAHIP CEECCCCCCCCCCCC	53.42	30108239
289	Phosphorylation	PAHIPPGSPPVSATA CCCCCCCCCCCCCCC	31.63	24719451
293	Phosphorylation	PPGSPPVSATAAGPE CCCCCCCCCCCCCCC	26.19	30108239
295	Phosphorylation	GSPPVSATAAGPEAS CCCCCCCCCCCCCCE	14.99	30108239
309	Phosphorylation	SFEARIPSPGTHPEG EEEEECCCCCCCCCC	33.32	23401153
312	Phosphorylation	ARIPSPGTHPEGEAA EECCCCCCCCCCHHH	37.33	29978859
326	Phosphorylation	AQRIHMKSCFLEDAT HHHHHHCHHCCCCCC	11.52	25690035
333	Phosphorylation	SCFLEDATIGNSNKM HHCCCCCCCCCCCCC	41.56	25690035
337	Phosphorylation	EDATIGNSNKMSISP CCCCCCCCCCCEECC	32.39	25690035
341 (in isoform 2)	Phosphorylation	-	22.86	22210691
343 (in isoform 2)	Phosphorylation	-	14.32	22210691
369 (in isoform 2)	Phosphorylation	-	30.58	22210691
386	Phosphorylation	RDIGQPITPSHSKLT CCCCCCCCCCCCCCC	25.97	28348404
395	Ubiquitination	SHSKLTPKLETMTLG CCCCCCCCCEEEECC	54.44	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZBP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZBP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZBP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRAF3_HUMAN	TRAF3	physical	21903422
CTBP1_HUMAN	CTBP1	physical	21903422
CTBP2_HUMAN	CTBP2	physical	21903422
FMR1_HUMAN	FMR1	physical	21903422
KDM1A_HUMAN	KDM1A	physical	21903422
ORC3_HUMAN	ORC3	physical	21903422
PALD_HUMAN	PALD1	physical	21903422
PXDC2_HUMAN	PLXDC2	physical	21903422
VPS35_HUMAN	VPS35	physical	21903422
ZN516_HUMAN	ZNF516	physical	21903422

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.