UST_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UST_HUMAN
• UniProt AC: Q9Y2C2
• Protein Name: Uronyl 2-sulfotransferase
• Gene Name: UST
• Organism: Homo sapiens (Human).
• Sequence Length: 406
• Subcellular Localization: Golgi apparatus membrane; Single-pass type II membrane protein.
• Protein Description: Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin..
• Protein Sequence: MKKKQQHPGGGADPWPHGAPMGGAPPGLGSWKRRVPLLPFLRFSLRDYGFCMATLLVFCLGSLLYQLSGGPPRFLLDLRQYLGNSTYLDDHGPPPSKVLPFPSQVVYNRVGKCGSRTVVLLLRILSEKHGFNLVTSDIHNKTRLTKNEQMELIKNISTAEQPYLFTRHVHFLNFSRFGGDQPVYINIIRDPVNRFLSNYFFRRFGDWRGEQNHMIRTPSMRQEERYLDINECILENYPECSNPRLFYIIPYFCGQHPRCREPGEWALERAKLNVNENFLLVGILEELEDVLLLLERFLPHYFKGVLSIYKDPEHRKLGNMTVTVKKTVPSPEAVQILYQRMRYEYEFYHYVKEQFHLLKRKFGLKSHVSKPPLRPHFFIPTPLETEEPIDDEEQDDEKWLEDIYKR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Ubiquitination	PPGLGSWKRRVPLLP CCCCCCHHHHCCCHH	31.83	22817900
44	Phosphorylation	LLPFLRFSLRDYGFC CHHHHHHHHHHHCHH	18.96	27966365
84	N-linked_Glycosylation	DLRQYLGNSTYLDDH HHHHHHCCCCCCCCC	28.69	UniProtKB CARBOHYD
115	Phosphorylation	NRVGKCGSRTVVLLL CCCCCCCHHHHHHHH	33.96	-
117	Phosphorylation	VGKCGSRTVVLLLRI CCCCCHHHHHHHHHH	19.36	-
126	Phosphorylation	VLLLRILSEKHGFNL HHHHHHHHHHHCCCE	42.08	24719451
140	N-linked_Glycosylation	LVTSDIHNKTRLTKN EECCCCCCCCCCCHH	47.96	UniProtKB CARBOHYD
155	N-linked_Glycosylation	EQMELIKNISTAEQP HHHHHHHHCCCCCCC	26.84	UniProtKB CARBOHYD
157	Phosphorylation	MELIKNISTAEQPYL HHHHHHCCCCCCCEE	30.84	-
158	Phosphorylation	ELIKNISTAEQPYLF HHHHHCCCCCCCEEE	30.34	-
173	N-linked_Glycosylation	TRHVHFLNFSRFGGD ECCEEECCHHHCCCC	31.72	UniProtKB CARBOHYD
319	N-linked_Glycosylation	PEHRKLGNMTVTVKK HHHCCCCCEEEEEEE	33.13	UniProtKB CARBOHYD
359	Ubiquitination	KEQFHLLKRKFGLKS HHHHHHHHHHHCCCC	60.96	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UST_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UST_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UST_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
S27A6_HUMAN	SLC27A6	physical	28514442
INHBE_HUMAN	INHBE	physical	28514442
PPT2_HUMAN	PPT2	physical	28514442
CALX_HUMAN	CANX	physical	28514442
DCAKD_HUMAN	DCAKD	physical	28514442
PON2_HUMAN	PON2	physical	28514442
GSLG1_HUMAN	GLG1	physical	28514442
GOLI4_HUMAN	GOLIM4	physical	28514442
XYLT2_HUMAN	XYLT2	physical	28514442
MA1A1_HUMAN	MAN1A1	physical	28514442
JAG2_HUMAN	JAG2	physical	28514442
OCAD1_HUMAN	OCIAD1	physical	28514442
LDLR_HUMAN	LDLR	physical	28514442
IMPA3_HUMAN	IMPAD1	physical	28514442
ERO1B_HUMAN	ERO1LB	physical	28514442
OMA1_HUMAN	OMA1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.