TINAG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TINAG_HUMAN
• UniProt AC: Q9UJW2
• Protein Name: Tubulointerstitial nephritis antigen
• Gene Name: TINAG
• Organism: Homo sapiens (Human).
• Sequence Length: 476
• Subcellular Localization: Secreted, extracellular space, extracellular matrix, basement membrane .
• Protein Description: Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein..
• Protein Sequence: MWTGYKILIFSYLTTEIWMEKQYLSQREVDLEAYFTRNHTVLQGTRFKRAIFQGQYCRNFGCCEDRDDGCVTEFYAANALCYCDKFCDRENSDCCPDYKSFCREEKEWPPHTQPWYPEGCFKDGQHYEEGSVIKENCNSCTCSGQQWKCSQHVCLVRSELIEQVNKGDYGWTAQNYSQFWGMTLEDGFKFRLGTLPPSPMLLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNCAASWAFSTASVAADRIAIQSKGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRGLVSHACYPLFKDQNATNNGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSNETEIMKEIMQNGPVQAIMQVREDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGTLRGAQGQKEKFWIAANSWGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MWTGYKILIF -----CCCCCEEEEE	29.36	23663014
5	Phosphorylation	---MWTGYKILIFSY ---CCCCCEEEEEHH	6.36	23663014
11	Phosphorylation	GYKILIFSYLTTEIW CCEEEEEHHHHHHHH	16.55	23663014
12	Phosphorylation	YKILIFSYLTTEIWM CEEEEEHHHHHHHHH	9.41	23663014
14	Phosphorylation	ILIFSYLTTEIWMEK EEEEHHHHHHHHHHH	17.72	23663014
15	Phosphorylation	LIFSYLTTEIWMEKQ EEEHHHHHHHHHHHH	23.91	23663014
38	N-linked_Glycosylation	LEAYFTRNHTVLQGT HHHHHCCCCCEECCC	31.93	UniProtKB CARBOHYD
112	O-linked_Glycosylation	EKEWPPHTQPWYPEG CCCCCCCCCCCCCCC	41.94	OGP
175	N-linked_Glycosylation	DYGWTAQNYSQFWGM CCCEECCCHHHHCCC	35.64	UniProtKB CARBOHYD
286	Phosphorylation	KNRHGCNSGSIDRAW HCCCCCCCCCHHHHH	37.68	29759185
314	N-linked_Glycosylation	YPLFKDQNATNNGCA HHHHCCCCCCCCCEE	59.89	UniProtKB CARBOHYD
345	Phosphorylation	CPNNVEKSNRIYQCS CCCCHHHCCCEEECC	20.17	-
352	Phosphorylation	SNRIYQCSPPYRVSS CCCEEECCCCCCCCC	17.24	-
360	N-linked_Glycosylation	PPYRVSSNETEIMKE CCCCCCCCHHHHHHH	53.34	UniProtKB CARBOHYD
389	Phosphorylation	EDFFHYKTGIYRHVT HHHHHHHHCCCCCCC	22.96	29083192
392	Phosphorylation	FHYKTGIYRHVTSTN HHHHHCCCCCCCCCC	8.94	29083192
420	Phosphorylation	VKLTGWGTLRGAQGQ HHHHCHHHHCCCCCC	13.53	24114839
455	N-linked_Glycosylation	FRILRGVNESDIEKL EEEEECCCHHHHHHH	45.97	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TINAG_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TINAG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TINAG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TM45B_HUMAN	TMEM45B	physical	21988832
TYW3_HUMAN	TYW3	physical	28514442
NUDT6_HUMAN	NUDT6	physical	28514442
EPDR1_HUMAN	EPDR1	physical	28514442
ACD11_HUMAN	ACAD11	physical	28514442
MOCS1_HUMAN	MOCS1	physical	28514442
CTU2_HUMAN	CTU2	physical	28514442
STK40_HUMAN	STK40	physical	28514442
RFWD2_HUMAN	RFWD2	physical	28514442
ZN696_HUMAN	ZNF696	physical	28514442
IDE_HUMAN	IDE	physical	28514442
CTU1_HUMAN	CTU1	physical	28514442
ZN579_HUMAN	ZNF579	physical	28514442
PP2AA_HUMAN	PPP2CA	physical	28514442
VP26A_HUMAN	VPS26A	physical	28514442
CUL1_HUMAN	CUL1	physical	28514442
CO4A1_HUMAN	COL4A1	physical	28514442
ALR_HUMAN	GFER	physical	28514442
ZN460_HUMAN	ZNF460	physical	28514442
TRAF7_HUMAN	TRAF7	physical	28514442
GRP78_HUMAN	HSPA5	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.