NUDT6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NUDT6_HUMAN
• UniProt AC: P53370
• Protein Name: Nucleoside diphosphate-linked moiety X motif 6
• Gene Name: NUDT6
• Organism: Homo sapiens (Human).
• Sequence Length: 316
• Subcellular Localization: Cytoplasm. Nucleus. Mitochondrion. Subcellular location may vary between isoforms.
• Protein Description: May contribute to the regulation of cell proliferation..
• Protein Sequence: MRQPLSWGRWRAMLARTYGPGPSAGYRWASGAQGYVRNPPVGACDLQGELDRFGGISVRLARLDALDRLDAAAFQKGLQAAVQQWRSEGRTAVWLHIPILQSRFIAPAASLGFCFHHAESDSSTLTLWLREGPSRLPGYASHQVGVAGAVFDESTRKILVVQDRNKLKNMWKFPGGLSEPEEDIGDTAVREVFEETGIKSEFRSVLSIRQQHTNPGAFGKSDMYIICRLKPYSFTINFCQEECLRCEWMDLNDLAKTENTTPITSRVARLLLYGYREGFDKIDLTVEELPAVYTGLFYKLYHKELPENYKTMKGID

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	WRAMLARTYGPGPSA HHHHHHHHHCCCCCC	27.50	23403867
18	Phosphorylation	RAMLARTYGPGPSAG HHHHHHHHCCCCCCC	18.77	23403867
23	Phosphorylation	RTYGPGPSAGYRWAS HHHCCCCCCCCCCCC	40.00	23403867
26	Phosphorylation	GPGPSAGYRWASGAQ CCCCCCCCCCCCCCC	11.60	23403867
57	Phosphorylation	LDRFGGISVRLARLD HHHCCCEEHHHHHHH	12.40	23186163
76	Ubiquitination	LDAAAFQKGLQAAVQ HHHHHHHHHHHHHHH	55.95	21890473
76 (in isoform 1)	Ubiquitination	-	55.95	21890473
303	Ubiquitination	LFYKLYHKELPENYK HHHHHHHCCCCHHHH	47.60	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NUDT6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NUDT6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NUDT6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IF2M_HUMAN	MTIF2	physical	26186194
P20D2_HUMAN	PM20D2	physical	26186194
ISCA1_HUMAN	ISCA1	physical	26186194
UBR2_HUMAN	UBR2	physical	26186194
GCSP_HUMAN	GLDC	physical	26186194
UBCP1_HUMAN	UBLCP1	physical	26186194
NEUG_HUMAN	NRGN	physical	26186194
DENR_HUMAN	DENR	physical	26186194
BOLA3_HUMAN	BOLA3	physical	26186194
UBR2_HUMAN	UBR2	physical	28514442
ISCA1_HUMAN	ISCA1	physical	28514442
NEUG_HUMAN	NRGN	physical	28514442
BOLA3_HUMAN	BOLA3	physical	28514442
UBCP1_HUMAN	UBLCP1	physical	28514442
DENR_HUMAN	DENR	physical	28514442
MMAB_HUMAN	MMAB	physical	28514442
IF2M_HUMAN	MTIF2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Ubiquitylation

"The proteomic reactor facilitates the analysis of affinity-purifiedproteins by mass spectrometry: application for identifyingubiquitinated proteins in human cells.";
Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M.,Haines D.S., Figeys D.;
J. Proteome Res. 6:298-305(2007).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-76, AND MASSSPECTROMETRY.
PubMed: 17203973