TFIP8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TFIP8_HUMAN
• UniProt AC: O95379
• Protein Name: Tumor necrosis factor alpha-induced protein 8
• Gene Name: TNFAIP8
• Organism: Homo sapiens (Human).
• Sequence Length: 198
• Subcellular Localization: Cytoplasm .
• Protein Description: Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation..
• Protein Sequence: MHSEAEESKEVATDVFNSKNLAVQAQKKILGKMVSKSIATTLIDDTSSEVLDELYRVTREYTQNKKEAEKIIKNLIKTVIKLAILYRNNQFNQDELALMEKFKKKVHQLAMTVVSFHQVDYTFDRNVLSRLLNECREMLHQIIQRHLTAKSHGRVNNVFDHFSDCEFLAALYNPFGNFKPHLQKLCDGINKMLDEENI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MHSEAEESKE -----CCCCHHHHHH	36.88	23401153
3 (in isoform 3)	Phosphorylation	-	36.88	20068231
8	Phosphorylation	MHSEAEESKEVATDV CCCCHHHHHHHHHHH	26.14	27486199
8 (in isoform 3)	Phosphorylation	-	26.14	20068231
27	Acetylation	NLAVQAQKKILGKMV HHHHHHHHHHHHHHH	44.81	11495491
27	2-Hydroxyisobutyrylation	NLAVQAQKKILGKMV HHHHHHHHHHHHHHH	44.81	-
28	Acetylation	LAVQAQKKILGKMVS HHHHHHHHHHHHHHC	30.96	11495499
36	Acetylation	ILGKMVSKSIATTLI HHHHHHCHHHHHHHC	34.18	11495507
36	Ubiquitination	ILGKMVSKSIATTLI HHHHHHCHHHHHHHC	34.18	-
78	Phosphorylation	IIKNLIKTVIKLAIL HHHHHHHHHHHHHHH	22.07	-
101	Ubiquitination	DELALMEKFKKKVHQ HHHHHHHHHHHHHHH	48.82	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TFIP8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TFIP8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TFIP8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MED4_HUMAN	MED4	physical	16189514
TP4A2_HUMAN	PTP4A2	physical	17353931
TP4A1_HUMAN	PTP4A1	physical	17353931
BACH_HUMAN	ACOT7	physical	22863883
DLDH_HUMAN	DLD	physical	22863883
DPP3_HUMAN	DPP3	physical	22863883
IF6_HUMAN	EIF6	physical	22863883
GRP75_HUMAN	HSPA9	physical	22863883
IPO5_HUMAN	IPO5	physical	22863883
NHLC2_HUMAN	NHLRC2	physical	22863883
IPP2_HUMAN	PPP1R2	physical	22863883
MED4_HUMAN	MED4	physical	25416956
PRR13_HUMAN	PRR13	physical	25416956
PKHF2_HUMAN	PLEKHF2	physical	25416956
TIFA_HUMAN	TIFA	physical	25416956
IN80E_HUMAN	INO80E	physical	25416956
PKHF2_HUMAN	PLEKHF2	physical	21516116
LATS1_HUMAN	LATS1	physical	28152516

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.