dbPTM

TERA_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TERA_RAT
UniProt AC	P46462
Protein Name	Transitional endoplasmic reticulum ATPase
Gene Name	Vcp
Organism	Rattus norvegicus (Rat).
Sequence Length	806
Subcellular Localization	Cytoplasm, cytosol . Endoplasmic reticulum . Nucleus . Recruited to the cytoplasmic surface of the endoplasmic reticulum via interaction with AMFR/gp78. Following DNA double-strand breaks, recruited to the sites of damage. Recruited to stalled replic
Protein Description	Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). [PubMed: 10930451]
Protein Sequence	MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTNPSAMEVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPSGNQGGAGPSQGSGGGTGGNVYTEDNDDDLYG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASGADSKG ------CCCCCCCCC	19.37	-
3	Phosphorylation	-----MASGADSKGD -----CCCCCCCCCC	32.96	27097102
7	Phosphorylation	-MASGADSKGDDLST -CCCCCCCCCCCHHH	37.69	27097102
8	Acetylation	MASGADSKGDDLSTA CCCCCCCCCCCHHHH	67.89	25786129
8	Ubiquitination	MASGADSKGDDLSTA CCCCCCCCCCCHHHH	67.89	-
13	Phosphorylation	DSKGDDLSTAILKQK CCCCCCHHHHHHHCC	23.84	28432305
14	Phosphorylation	SKGDDLSTAILKQKN CCCCCHHHHHHHCCC	25.64	28432305
18	Acetylation	DLSTAILKQKNRPNR CHHHHHHHCCCCCCC	53.78	22902405
37	Phosphorylation	EAINEDNSVVSLSQP ECCCCCCCEEECCCC	35.90	-
60	Acetylation	RGDTVLLKGKKRREA CCCEEEECCCCCCEE	65.60	22902405
73	Phosphorylation	EAVCIVLSDDTCSDE EEEEEEEECCCCCHH	23.65	25575281
76	Phosphorylation	CIVLSDDTCSDEKIR EEEEECCCCCHHHHC	20.92	25575281
78	Phosphorylation	VLSDDTCSDEKIRMN EEECCCCCHHHHCHH	51.39	25575281
148	Succinylation	EAYRPIRKGDIFLVR HHHCCCCCCCEEEEE	62.75	26843850
197	Phosphorylation	KREDEEESLNEVGYD CCCCCHHHHHHCCCC	39.51	29779826
231	Ubiquitination	LRHPALFKAIGVKPP CCCHHHHHHCCCCCC	39.69	-
236	Ubiquitination	LFKAIGVKPPRGILL HHHHCCCCCCCEEEE	44.05	-
282	Phosphorylation	MSKLAGESESNLRKA HHHHCCCCHHHHHHH	45.46	27097102
284	Phosphorylation	KLAGESESNLRKAFE HHCCCCHHHHHHHHH	50.90	27097102
288	Acetylation	ESESNLRKAFEEAEK CCHHHHHHHHHHHHH	61.67	22902405
288	Succinylation	ESESNLRKAFEEAEK CCHHHHHHHHHHHHH	61.67	26843850
315	Methylation	AIAPKREKTHGEVER HHCCCCCCCCHHHHH	50.26	-
315	"N6,N6,N6-trimethyllysine"	AIAPKREKTHGEVER HHCCCCCCCCHHHHH	50.26	-
336	Acetylation	LTLMDGLKQRAHVIV HHHHHHHHHCCEEEE	43.18	22902405
336	Ubiquitination	LTLMDGLKQRAHVIV HHHHHHHHHCCEEEE	43.18	-
436	Phosphorylation	LIDLEDETIDAEVMN CCCCCCCCCCHHHHH	36.16	-
457	Phosphorylation	DDFRWALSQSNPSAL HHHHHHHHCCCHHHH	24.66	27097102
459	Phosphorylation	FRWALSQSNPSALRE HHHHHHCCCHHHHHH	47.54	27097102
462	Phosphorylation	ALSQSNPSALRETVV HHHCCCHHHHHHHEE	44.16	27097102
502	Ubiquitination	YPVEHPDKFLKFGMT CCCCCCCCCCCCCCC	57.98	-
502	Acetylation	YPVEHPDKFLKFGMT CCCCCCCCCCCCCCC	57.98	-
505	Acetylation	EHPDKFLKFGMTPSK CCCCCCCCCCCCCCC	42.90	-
509	Phosphorylation	KFLKFGMTPSKGVLF CCCCCCCCCCCCEEE	25.45	28432305
565	Acetylation	NVREIFDKARQAAPC HHHHHHHHHHHHCCE	34.42	22902405
614	Ubiquitination	EMDGMSTKKNVFIIG HCCCCCCCCCEEEEE	34.74	-
651	Acetylation	YIPLPDEKSRVAILK EEECCCHHHHEEHHH	51.44	22902405
651	Ubiquitination	YIPLPDEKSRVAILK EEECCCHHHHEEHHH	51.44	-
658	Ubiquitination	KSRVAILKANLRKSP HHHEEHHHHHCCCCC	29.17	-
668	Ubiquitination	LRKSPVAKDVDLEFL CCCCCCCCCCCHHHH	59.52	-
668	Succinylation	LRKSPVAKDVDLEFL CCCCCCCCCCCHHHH	59.52	-
668	Succinylation	LRKSPVAKDVDLEFL CCCCCCCCCCCHHHH	59.52	-
668	Acetylation	LRKSPVAKDVDLEFL CCCCCCCCCCCHHHH	59.52	22902405
702	Phosphorylation	CKLAIRESIESEIRR HHHHHHHHHHHHHHH	23.08	22108457
705	Phosphorylation	AIRESIESEIRRERE HHHHHHHHHHHHHHH	36.33	23984901
748	Phosphorylation	RFARRSVSDNDIRKY HHHHHCCCHHHHHHH	31.76	22673903
754	Acetylation	VSDNDIRKYEMFAQT CCHHHHHHHHHHHHH	45.99	22902405
770	Phosphorylation	QQSRGFGSFRFPSGN HHHCCCCCEECCCCC	15.81	25532521
775	Phosphorylation	FGSFRFPSGNQGGAG CCCEECCCCCCCCCC	47.89	28689409
784	Phosphorylation	NQGGAGPSQGSGGGT CCCCCCCCCCCCCCC	46.38	28689409
787	Phosphorylation	GAGPSQGSGGGTGGN CCCCCCCCCCCCCCC	26.99	28689409
797	Phosphorylation	GTGGNVYTEDNDDDL CCCCCCCCCCCCCCC	32.36	28689409
805	Phosphorylation	EDNDDDLYG------ CCCCCCCCC------	27.99	22276854

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
352	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
746	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
748	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
315	K	Methylation	-
Lys-315 methylation may decrease ATPase activity.
315	K	Methylation	-
Methylation at Lys-315 catalyzed by VCPKMT is increased in the presence of ASPSCR1.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TERA_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBX2B_RAT	Ubxn2b	physical	17141156
TERA_RAT	Vcp	physical	12351637
UFD1_RAT	Ufd1l	physical	12847084
NSF1C_RAT	Nsfl1c	physical	12847084
CALX_RAT	Canx	physical	12847084
B2MG_RAT	B2m	physical	12847084
UBC_RAT	Ubc	physical	12847084
NF1_RAT	Nf1	physical	22105171
NSF1C_RAT	Nsfl1c	physical	10811609
UFD1_RAT	Ufd1l	physical	10811609
UBE4A_RAT	Ube4a	physical	10811609
NPL4_RAT	Nploc4	physical	10811609

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TERA_RAT

Related Literatures of Post-Translational Modification

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