UBE4A_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBE4A_RAT
• UniProt AC: Q6P7A2
• Protein Name: Ubiquitin conjugation factor E4 A {ECO:0000305}
• Gene Name: Ube4a {ECO:0000312|RGD:1303173}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1066
• Subcellular Localization: Cytoplasm .
• Protein Description: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates..
• Protein Sequence: MTDQENNNNISSNPFAALFGSLADAKQFAAIHKEQLKQQSDELPASPDDSDNSVSESLDEFDYSVSEISRSFRTHQEMCEQLNINHMIQRIFLITLDNSDPNLKSGNGIPSRCVYLEEMAVELEDQDWLDMSNVEQAIFARLLLQDPGNHLISMTSSATLNLSADRDAGERHIFCYLYSCFQRAKEEITKVPENLLPFAVQCRNLTVSNTRTVLLTPEIYVDQNIHEQLVDLMLEAIQGAHFEDVTEFLEEVIEALLLDEEVRTFPEVMIPVFDILLGRIKDLELCQILLYAYLDILLYFTRQKDMAKVFLEYIQPKDPSNGQMYQKTLLGVILNISCLLKTPGVVENHGFFLNPSRSSPQEIKVQEANIHQFMAQFHEKIYQMLKNLLQLSPETKHGILFWLGNCLHANAGRTKIWANQMPEIFFQMYASDAFFLNLGAALLKLCQPFCKPRSSRLLTFNPTYCVLKDLNDEERKIKSVHMRGLDKETCLIPAVQEPVFPQSYNLVTENLALTEYTLYLGFHRLHDQMVKINQNLHRLQVAWRDAQQSSSPAADNLREQFERLMTIYLSTKTAMTEPQMLQNCLNLQVSMAVLLVQLAIGNEGSQPIELSFPLPDGYSSLAYVPEFFADNLGDFLIFLRRFAEDILETSADSLEHVLHFITIFTGSIERMKNPHLRAKLAEVLEAVMPHLDQTPSPLVSSVFHRKRVFCNFPYAPQLSEALIKVFVDIEFTGDPHQFEQKFNYRRPMYPILRYMWGTDSYRESIKDLADYASKNLEAMNPPLFLRFLNLLMNDAIFLLDEAIQYLSKIKIQQIEKDRGEWESLTPEARREKEAGLQMFGQLARFHNIMSNETIGTLSFLTSEIKSLFVHPFLAERIISMLNYFLQHLVGPKMGALKVKDFSEFDFKPQQLVSDICTIYLNLGDEENFCATVPKDGRSYSPTLFAQTVRVLKKINKPGNMIVAFSNLAERIKSLADLQQQEEETYADACDEFLDPIMSTLMSDPVVLPSSRVTVDGSTIARHLLSDQTDPFNRSPLTMDQIRPNTELKEKIQRWLAERKQQKEQLE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
105	Phosphorylation	NSDPNLKSGNGIPSR CCCCCCCCCCCCCCC	40.43	22108457
386	Acetylation	EKIYQMLKNLLQLSP HHHHHHHHHHHCCCC	39.96	-
938	Phosphorylation	TVPKDGRSYSPTLFA ECCCCCCCCCCCHHH	35.18	28432305
939	Phosphorylation	VPKDGRSYSPTLFAQ CCCCCCCCCCCHHHH	19.80	28432305
940	Phosphorylation	PKDGRSYSPTLFAQT CCCCCCCCCCHHHHH	16.80	28432305
942	Phosphorylation	DGRSYSPTLFAQTVR CCCCCCCCHHHHHHH	28.68	28432305

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBE4A_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBE4A_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBE4A_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of UBE4A_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.