NF1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NF1_RAT
• UniProt AC: P97526
• Protein Name: Neurofibromin
• Gene Name: Nf1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 2820
• Subcellular Localization: Nucleus. Nucleus, nucleolus.
• Protein Description: Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity (By similarity)..
• Protein Sequence: MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELLQYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQTDMAECAGKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISRDVVDENNTNKKLFLDSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNPSKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITNSAWDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPALRMAPSLTFKEKVTSLKFKEKPTDLEARSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSHMPEVAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYICKKLTSHQMLSSTEILKWLREILICRNKFLLKNKQADRSSCHSLYLYGVGCDLPASGNVTQMSVDHEESLRTCAPGASLRKGRGNSSMDSTAGCSGTPPICRQAQTKLEVALYMFLWSPDTEVVLVAMSCFRHLCEEADIRCGVDEVSVHNFLPNYNTFMEFASVSNMLSTGRAALQKRVMALLRRIEHPTAGNTEAWEDTHAKWEQATKLILNYPKAKMEDGQAAESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWINMTGFLCALGGVCLQQRSSSGLATYSPPMGPVSERKGSMISVMSSEGNVDSPVSRFMDRLLSLMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKSAISKFFDSQGQVLLTDSNTQFVEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHAIQIKTKLCQLVEVMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVSLLAGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDENAQTGGRKRGMSRRLASLRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAETVLADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIIITSSDWQHVSFEVDPTRLEPSESLEENQRNLLQMTEKFFHAIISSSSEFPSQLRSVCHCLYQVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKVLQSIANHVLFTKEEHMRPFNDFVKSNFDLARRFFLDIASDCPTSDAVNHSLSFISDGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTHWSSLNLTSSKFEEFMTRHQVHEKEEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQINGDLLIYHVLLTLKPYYAKPYEIVVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVYIYNCNSWVREYTKYHERLLTGLKGSKRLIFIDCPGKLAEHIEHEQQKLPAATLALEEDLKVFHNALKLAHKDTKVSIKVGSTAVQVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQFTLTIANQGTPLTFMHQECEAIVQSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIALLNLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAANEPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKLITMTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVALASGNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAAHLPYLFHVVTFLVATGPLSLRASTHGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSLPKFYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALTSLETVTEALLEIMEACMRDIPTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGCISKRVSHGQIKQIIRILSKALESCLKGPDTYNSQVLIEATVIALTKLQPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALLEQNLHTLDSLRIFNDKSPEEVFMAIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGYRHPSPAIVARTVRILHTLLTLVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHRKSLLLTDISMENVPMDTYPIHHGDPSSRTLKETQPWSSPRGSEGYLAATYPAVGQTSPRARKSMSLDMGQPSQANTKKLLGTRKSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYEMETQRISSSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRILYEYLAEASVVFPKVFPLVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQYQTSYLQSFGFNGLWRFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTPTSPYPPALQSQLSITANLNLSNSMTSLATSQHSPGIDKENVELSPTTGHCNSGRTRHGSASQVQKQRSAGSFKRNSIKKIV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAHRPVEW ------CCCCCCHHH	24.23	-
465	Phosphorylation	PALRMAPSLTFKEKV HHHHCCCCCCHHHHH	30.42	28432305
467	Phosphorylation	LRMAPSLTFKEKVTS HHCCCCCCHHHHHHC	36.68	28432305
659	Phosphorylation	RTCAPGASLRKGRGN CCCCCCCCCCCCCCC	34.32	25575281
667	Phosphorylation	LRKGRGNSSMDSTAG CCCCCCCCCCCCCCC	29.84	28432305
668	Phosphorylation	RKGRGNSSMDSTAGC CCCCCCCCCCCCCCC	30.52	28432305
671	Phosphorylation	RGNSSMDSTAGCSGT CCCCCCCCCCCCCCC	16.12	27097102
672	Phosphorylation	GNSSMDSTAGCSGTP CCCCCCCCCCCCCCC	23.86	25575281
858	Phosphorylation	GVCLQQRSSSGLATY CCEEEECCCCCCCCC	25.23	27097102
859	Phosphorylation	VCLQQRSSSGLATYS CEEEECCCCCCCCCC	30.52	27097102
860	Phosphorylation	CLQQRSSSGLATYSP EEEECCCCCCCCCCC	38.79	27097102
864	Phosphorylation	RSSSGLATYSPPMGP CCCCCCCCCCCCCCC	29.58	27097102
865	Phosphorylation	SSSGLATYSPPMGPV CCCCCCCCCCCCCCC	17.36	30181290
866	Phosphorylation	SSGLATYSPPMGPVS CCCCCCCCCCCCCCC	20.41	23589303
873	Phosphorylation	SPPMGPVSERKGSMI CCCCCCCCCCCCCEE	34.51	30181290
878	Phosphorylation	PVSERKGSMISVMSS CCCCCCCCEEEEECC	18.91	16641100
881	Phosphorylation	ERKGSMISVMSSEGN CCCCCEEEEECCCCC	11.79	28432305
884	Phosphorylation	GSMISVMSSEGNVDS CCEEEEECCCCCCCC	24.07	16641100
885	Phosphorylation	SMISVMSSEGNVDSP CEEEEECCCCCCCCH	31.28	16641100
891	Phosphorylation	SSEGNVDSPVSRFMD CCCCCCCCHHHHHHH	23.95	16641100
1142	Phosphorylation	GMSRRLASLRHCTVL HHHHHHHHHHHHHHH	30.44	22673903
2167	Phosphorylation	RSSYRDRSFSPGSYE CCCCCCCCCCCCCHH	34.07	28432305
2169	Phosphorylation	SYRDRSFSPGSYERE CCCCCCCCCCCHHHC	29.60	27097102
2172	Phosphorylation	DRSFSPGSYERETFA CCCCCCCCHHHCCEE	27.49	27097102
2448	Phosphorylation	SLLLTDISMENVPMD HHEEEECCCCCCCCC	23.89	-
2476	Phosphorylation	LKETQPWSSPRGSEG CCCCCCCCCCCCCCC	36.83	28432305
2477	Phosphorylation	KETQPWSSPRGSEGY CCCCCCCCCCCCCCE	18.10	28432305
2481	Phosphorylation	PWSSPRGSEGYLAAT CCCCCCCCCCEEEEC	29.18	28432305
2484	Phosphorylation	SPRGSEGYLAATYPA CCCCCCCEEEECCCC	6.79	28432305
2488	Phosphorylation	SEGYLAATYPAVGQT CCCEEEECCCCCCCC	25.16	27097102
2489	Phosphorylation	EGYLAATYPAVGQTS CCEEEECCCCCCCCC	5.62	27097102
2495	Phosphorylation	TYPAVGQTSPRARKS CCCCCCCCCCCHHHH	34.47	27097102
2496	Phosphorylation	YPAVGQTSPRARKSM CCCCCCCCCCHHHHC	12.42	27097102
2502	Phosphorylation	TSPRARKSMSLDMGQ CCCCHHHHCCCCCCC	14.19	27097102
2504	Phosphorylation	PRARKSMSLDMGQPS CCHHHHCCCCCCCCC	28.45	27097102
2524	Phosphorylation	KLLGTRKSFDHLISD HHHCCHHHHHHHHCC	32.39	29779826
2530	Phosphorylation	KSFDHLISDTKAPKR HHHHHHHCCCCCCCH	45.66	25575281
2532	Phosphorylation	FDHLISDTKAPKRQE HHHHHCCCCCCCHHH	23.47	25575281
2536	Acetylation	ISDTKAPKRQEMESG HCCCCCCCHHHHHCC	72.13	26302492
2542	Phosphorylation	PKRQEMESGITTPPK CCHHHHHCCCCCCHH	33.90	25575281
2545	Phosphorylation	QEMESGITTPPKMRR HHHHCCCCCCHHHHH	36.45	25403869
2546	Phosphorylation	EMESGITTPPKMRRV HHHCCCCCCHHHHHH	35.36	30240740
2549	Acetylation	SGITTPPKMRRVAET CCCCCCHHHHHHHCC	46.36	26302492
2578	Phosphorylation	HPHLRKVSVSESNVL CCCCEECCCCCCCCC	23.98	30240740
2580	Phosphorylation	HLRKVSVSESNVLLD CCEECCCCCCCCCCC	28.00	28432305
2582	Phosphorylation	RKVSVSESNVLLDEE EECCCCCCCCCCCHH	25.40	28432305
2783	Phosphorylation	DKENVELSPTTGHCN CHHCEEECCCCCCCC	13.49	27097102
2785	Phosphorylation	ENVELSPTTGHCNSG HCEEECCCCCCCCCC	41.87	27097102
2786	Phosphorylation	NVELSPTTGHCNSGR CEEECCCCCCCCCCC	28.45	27097102
2791	Phosphorylation	PTTGHCNSGRTRHGS CCCCCCCCCCCCCCC	34.74	27097102
2798	Phosphorylation	SGRTRHGSASQVQKQ CCCCCCCCHHHHHHH	20.72	29779826
2810	Phosphorylation	QKQRSAGSFKRNSIK HHHHHCCCCCHHHCH	27.58	28432305

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NF1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NF1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NF1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TERA_RAT	Vcp	physical	22105171
SDC3_RAT	Sdc3	physical	11356864
CSKP_RAT	Cask	physical	11356864

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.