UBX2B_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBX2B_RAT
• UniProt AC: P0C627
• Protein Name: UBX domain-containing protein 2B
• Gene Name: Ubxn2b
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 331
• Subcellular Localization: Nucleus . Cytoplasm, cytosol . Endoplasmic reticulum . Golgi apparatus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Localizes to centrosome during mitotic prophase and metaphase.
• Protein Description: Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity. Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis..
• Protein Sequence: MAEGGGAEPEEQERRSSRPRPPSARDLQLALAELYEDEMKCKSSKPDRSTATAFKSPRTPPLRLYSGDQEYGGLHIAQPPTGKIVNELFKEAREHGAVPLNEATRSSSDDKAKSFTGGGYRLGSSFYKRSEYIYGENQLQDVQILLRLWSNGFSLDDGELRPYSDPTNAQFLESVKRGEIPLELQRLVHGSQVSLDMEDHQDQEYIKPRLRFKAFSGEGQKLGSLTPEIVSTPSSPEEEDKSILNAAVLIDDSVPTTKIQIRLADGSRLIQRFNSTHRILDVRDFIVQSRPEFATTDFILVTSFPSKELTDESVTLQDADILNTVILQQLK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEGGGAEP ------CCCCCCCCH	24.92	-
56	Phosphorylation	STATAFKSPRTPPLR HHCHHCCCCCCCCEE	17.11	28432305
59	Phosphorylation	TAFKSPRTPPLRLYS HHCCCCCCCCEEEEE	32.42	28432305
65	Phosphorylation	RTPPLRLYSGDQEYG CCCCEEEEECCCEEC	12.27	25575281
66	Phosphorylation	TPPLRLYSGDQEYGG CCCEEEEECCCEECC	40.25	22108457
71	Phosphorylation	LYSGDQEYGGLHIAQ EEECCCEECCEEECC	15.74	22108457
81	Phosphorylation	LHIAQPPTGKIVNEL EEECCCCCCHHHHHH	58.76	25575281
90	Acetylation	KIVNELFKEAREHGA HHHHHHHHHHHHCCC	64.19	22902405
191	Phosphorylation	LQRLVHGSQVSLDME HHHHHCCCEEECCCC	16.72	25575281
194	Phosphorylation	LVHGSQVSLDMEDHQ HHCCCEEECCCCCCC	15.83	25575281
216	Phosphorylation	RLRFKAFSGEGQKLG EEEEEEECCCCCCCC	40.57	28432305
224	Phosphorylation	GEGQKLGSLTPEIVS CCCCCCCCCCCCHHC	39.23	28432305
226	Phosphorylation	GQKLGSLTPEIVSTP CCCCCCCCCCHHCCC	22.14	28432305
231	Phosphorylation	SLTPEIVSTPSSPEE CCCCCHHCCCCCCHH	40.02	28551015
232	Phosphorylation	LTPEIVSTPSSPEEE CCCCHHCCCCCCHHH	19.12	27097102
234	Phosphorylation	PEIVSTPSSPEEEDK CCHHCCCCCCHHHCH	59.62	27097102
235	Phosphorylation	EIVSTPSSPEEEDKS CHHCCCCCCHHHCHH	37.22	27097102
267	Phosphorylation	QIRLADGSRLIQRFN EEEECCHHHHHHHHH	25.18	29779826

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBX2B_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBX2B_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBX2B_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TERA_RAT	Vcp	physical	17141156

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.