NPL4_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NPL4_RAT
• UniProt AC: Q9ES54
• Protein Name: Nuclear protein localization protein 4 homolog
• Gene Name: Nploc4
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 608
• Subcellular Localization: Cytoplasm, cytosol . Endoplasmic reticulum . Nucleus . Associated with the endoplasmic reticulum and nuclear.
• Protein Description: The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. [PubMed: 10811609]
• Protein Sequence: MAESIIIRVQSPDGVKRITATKRETAATFLKKVAKEFGFQNNGFSVYINRNKTGEITASSSKSLHLLKIKHGDLLFLFPSSLAGPSSEMETSTSVGLKAFGAPHVVEDEIDQYLSKQDGKIYRSRDPQLCRHGPLGKCVHCVPLEPFDEDYLNHLEPPVKHMSFHAYIRKLTGGADKGKFVALENISCKIKSGCEGHLPWPNGICTKCQPSAITLNRQKYRHVDNIMFENHTVADRFLDFWRKTGNQHFGYLYGRYTEHKDIPLGIRAEVAAIYEPPQIGTQNSLELLEDPKAEVVDEIASKLGLRKVGWIFTDLVSEDTRKGTVRYSRNKDTYFLSSEECITAGDFQNKHPNICRLSPDGHFGSKFVTAVATGGPDNQVHFEGYQVSNQCMALVRDECLLPCKDAPELGYAKESSSEQYVPDVFYKDIDKFGNEITQLARPLPVEYLIIDITTTFPKDPVYTFSISQNPFPIENRDVLGETQDFHSLATYLSQNTSSVFLDTISDFHLLLFLVTNEVMPLQDSISLLLEAVRTRNEELAQTWKKSEQWATIEQLCSTVGVQLPGLHEFGAVGGSARAATSAMWACQHCTFMNQPGTGHCEMCSLPRT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAESIIIRV ------CCCEEEEEE	21.17	-
57	Phosphorylation	RNKTGEITASSSKSL CCCCCCEEECCCCCE	19.04	25575281
59	Phosphorylation	KTGEITASSSKSLHL CCCCEEECCCCCEEE	26.88	25575281
60	Phosphorylation	TGEITASSSKSLHLL CCCEEECCCCCEEEE	39.04	25575281
61	Phosphorylation	GEITASSSKSLHLLK CCEEECCCCCEEEEE	24.62	25575281
63	Phosphorylation	ITASSSKSLHLLKIK EEECCCCCEEEEEEE	23.99	25575281
179	Acetylation	TGGADKGKFVALENI HCCCCCCCEEEEEEE	42.26	-
187	Phosphorylation	FVALENISCKIKSGC EEEEEEEEEEEECCC	22.42	23984901
214	Phosphorylation	KCQPSAITLNRQKYR CCCCCEEEECCHHHC	20.07	23984901
426	Phosphorylation	QYVPDVFYKDIDKFG CCCCCHHHHCHHHHH	13.96	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NPL4_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NPL4_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NPL4_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TERA_RAT	Vcp	physical	10811609
UFD1_RAT	Ufd1l	physical	10811609
UFD1_MOUSE	Ufd1l	physical	22232657
TERA_MOUSE	Vcp	physical	22232657
UBC_HUMAN	UBC	physical	15029239

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.