SWT11_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SWT11_ARATH
• UniProt AC: Q9SMM5
• Protein Name: Bidirectional sugar transporter SWEET11 {ECO:0000303|PubMed:21107422}
• Gene Name: SWEET11 {ECO:0000303|PubMed:21107422}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 289
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein. Present in the plasma membrane of the phloem.
• Protein Description: Mediates both low-affinity uptake and efflux of sugar across the plasma membrane. Involved in phloem loading by mediating export from parenchyma cells feeding H(+)-coupled import into the sieve element/companion cell complex, thus contributing to the sucrose migration from sites of synthesis in the mesophyll to the phloem. [PubMed: 22157085]
• Protein Sequence: MSLFNTENTWAFVFGLLGNLISFAVFLSPVPTFYRIWKKKTTEGFQSIPYVVALFSATLWLYYATQKKDVFLLVTINAFGCFIETIYISMFLAYAPKPARMLTVKMLLLMNFGGFCAILLLCQFLVKGATRAKIIGGICVGFSVCVFAAPLSIIRTVIKTRSVEYMPFSLSLTLTISAVIWLLYGLALKDIYVAFPNVLGFALGALQMILYVVYKYCKTSPHLGEKEVEAAKLPEVSLDMLKLGTVSSPEPISVVRQANKCTCGNDRRAEIEDGQTPKHGKQSSSAAAT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
237	Phosphorylation	AAKLPEVSLDMLKLG HHCCCCCCHHHHCCC	19.59	25561503
245	Phosphorylation	LDMLKLGTVSSPEPI HHHHCCCCCCCCCCC	27.87	23776212
247	Phosphorylation	MLKLGTVSSPEPISV HHCCCCCCCCCCCHH	39.76	23776212
248	Phosphorylation	LKLGTVSSPEPISVV HCCCCCCCCCCCHHH	29.01	30291188
253	Phosphorylation	VSSPEPISVVRQANK CCCCCCCHHHHHCCC	25.85	23776212
276	Phosphorylation	AEIEDGQTPKHGKQS CEECCCCCCCCCCCC	39.57	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SWT11_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SWT11_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SWT11_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SWET1_ARATH	AT1G21460	physical	24027245
SWET3_ARATH	AT5G53190	physical	24027245
SWET5_ARATH	AtVEX1	physical	24027245
SWET6_ARATH	AT1G66770	physical	24027245
SWET7_ARATH	AT4G10850	physical	24027245
SWET8_ARATH	AT5G40260	physical	24027245
SWET9_ARATH	AT2G39060	physical	24027245
SWT11_ARATH	AT3G48740	physical	24027245
SWT12_ARATH	MTN3	physical	24027245
SWT13_ARATH	AT5G50800	physical	24027245
SWT17_ARATH	AT4G15920	physical	24027245

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-248 AND THR-276, ANDMASS SPECTROMETRY.
PubMed: 19376835