dbPTM

SPT46_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SPT46_HUMAN
UniProt AC	Q5T0L3
Protein Name	Spermatogenesis-associated protein 46 {ECO:0000303\|PubMed:27488028}
Gene Name	SPATA46 {ECO:0000312\|HGNC:HGNC:27648}
Organism	Homo sapiens (Human).
Sequence Length	261
Subcellular Localization	Nucleus membrane . Located throughout the subacrosomal area.
Protein Description	Play a role in spermiogenesis and fertilization..
Protein Sequence	MENFSLLSISGPPISSSALSAFPDIMFSRATSLPDIAKTAVPTEASSPAQALPPQYQSIIVRQGIQNTALSPDCSLGDTQHGEKLRRNCTIYRPWFSPYSYFVCADKESQLEAYDFPEVQQDEGKWDNCLSEDMAENICSSSSSPENTCPREATKKSRHGLDSITSQDILMASRWHPAQQNGYKCVACCRMYPTLDFLKSHIKRGFREGFSCKVYYRKLKALWSKEQKARLGDRLSSGSCQAFNSPAEHLRQIGGEAYLCL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
192	Phosphorylation	CVACCRMYPTLDFLK EEEECCCCCCHHHHH	28331001
194	Phosphorylation	ACCRMYPTLDFLKSH EECCCCCCHHHHHHH	28331001
199	Sumoylation	YPTLDFLKSHIKRGF CCCHHHHHHHHHHCH	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SPT46_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SPT46_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SPT46_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
KC1A_HUMAN	CSNK1A1	physical	26186194
MGLL_HUMAN	MGLL	physical	26186194
BPL1_HUMAN	HLCS	physical	26186194
GAPD1_HUMAN	GAPVD1	physical	26186194
TYW5_HUMAN	TYW5	physical	26186194
MDM4_HUMAN	MDM4	physical	26186194
SNX24_HUMAN	SNX24	physical	26186194
CEP95_HUMAN	CEP95	physical	26186194
SNX24_HUMAN	SNX24	physical	28514442
MDM4_HUMAN	MDM4	physical	28514442
GAPD1_HUMAN	GAPVD1	physical	28514442
KC1A_HUMAN	CSNK1A1	physical	28514442
TYW5_HUMAN	TYW5	physical	28514442
MGLL_HUMAN	MGLL	physical	28514442
BPL1_HUMAN	HLCS	physical	28514442

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SPT46_HUMAN

Related Literatures of Post-Translational Modification