SEP12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SEP12_HUMAN
• UniProt AC: Q8IYM1
• Protein Name: Septin-12
• Gene Name: 12-Sep
• Organism: Homo sapiens (Human).
• Sequence Length: 358
• Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, spindle . Nucleus . Cell projection, cilium, flagellum . At interphase, forms a filamentous structure in the cytoplasm. During anaphase, translocates to the central spindle region and to t
• Protein Description: Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins. [PubMed: 24213608 Forms a filamentous structure with SEPT7, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation]
• Protein Sequence: MDPLRRSPSPCLSSQPSSPSTPPCEMLGPVGIEAVLDQLKIKAMKMGFEFNIMVVGQSGLGKSTMVNTLFKSKVWKSNPPGLGVPTPQTLQLHSLTHVIEEKGVKLKLTVTDTPGFGDQINNDNCWDPILGYINEQYEQYLQEEILITRQRHIPDTRVHCCVYFVPPTGHCLRPLDIEFLQRLCRTVNVVPVIARADSLTMEEREAFRRRIQQNLRTHCIDVYPQMCFDEDINDKILNSKLRDRIPFAVVGADQEHLVNGRCVLGRKTKWGIIEVENMAHCEFPLLRDLLIRSHLQDLKDITHNIHYENYRVIRLNESHLLPRGPGWVNLAPASPGQLTTPRTFKVCRGAHDDSDDEF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	Phosphorylation	NIMVVGQSGLGKSTM EEEEECCCCCCCHHH	30.01	23532336
71	Acetylation	TMVNTLFKSKVWKSN HHHHHHHHHCCHHCC	53.10	25038526
72	Phosphorylation	MVNTLFKSKVWKSNP HHHHHHHHCCHHCCC	25.71	23532336
198	Phosphorylation	PVIARADSLTMEERE HEEEECCCCCHHHHH	25.42	-
318	Phosphorylation	RVIRLNESHLLPRGP EEEEECCCCCCCCCC	20.54	24719451
339	Phosphorylation	PASPGQLTTPRTFKV CCCCCCCCCCCCEEE	27.20	24719451
354	Phosphorylation	CRGAHDDSDDEF--- CCCCCCCCCCCC---	53.68	30622161

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
198	S	Phosphorylation	Kinase	PRKACA	P17612-2	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SEP12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SEP12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
TCPH_HUMAN	CCT7	physical	26186194
SEPT4_HUMAN	SEPT4	physical	26186194
SEPT2_HUMAN	SEPT2	physical	26186194
SEPT7_HUMAN	SEPT7	physical	26186194
SEPT5_HUMAN	SEPT5	physical	26186194
SEPT6_HUMAN	SEPT6	physical	26186194
SEPT8_HUMAN	SEPT8	physical	26186194
SEP11_HUMAN	SEPT11	physical	26186194
SEP10_HUMAN	SEPT10	physical	26186194
TCPW_HUMAN	CCT6B	physical	26186194
SEPT3_HUMAN	SEPT3	physical	26186194
PDS5B_HUMAN	PDS5B	physical	26186194
GDS1_HUMAN	RAP1GDS1	physical	26186194
SEPT1_HUMAN	SEPT1	physical	21516116
SEPT5_HUMAN	SEPT5	physical	28514442
SEPT2_HUMAN	SEPT2	physical	28514442
SEP10_HUMAN	SEPT10	physical	28514442
SEPT8_HUMAN	SEPT8	physical	28514442
SEPT4_HUMAN	SEPT4	physical	28514442
PDS5B_HUMAN	PDS5B	physical	28514442
SEPT6_HUMAN	SEPT6	physical	28514442
SEP11_HUMAN	SEPT11	physical	28514442
SEPT7_HUMAN	SEPT7	physical	28514442
SEPT3_HUMAN	SEPT3	physical	28514442
TCPW_HUMAN	CCT6B	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.