RPC7L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RPC7L_HUMAN
• UniProt AC: Q9BT43
• Protein Name: DNA-directed RNA polymerase III subunit RPC7-like
• Gene Name: POLR3GL
• Organism: Homo sapiens (Human).
• Sequence Length: 218
• Subcellular Localization: Nucleus .
• Protein Description: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs..
• Protein Sequence: MASRGGGRGRGRGQLTFNVEAVGIGKGDALPPPTLQPSPLFPPLEFRPVPLPSGEEGEYVLALKQELRGAMRQLPYFIRPAVPKRDVERYSDKYQMSGPIDNAIDWNPDWRRLPRELKIRVRKLQKERITILLPKRPPKTTEDKEETIQKLETLEKKEEEVTSEEDEEKEEEEEKEEEEEEEYDEEEHEEETDYIMSYFDNGEDFGGDSDDNMDEAIY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Methylation	GGGRGRGRGQLTFNV CCCCCCCCCEEEEEE	28.46	115488205
59	Phosphorylation	PSGEEGEYVLALKQE CCCCCCCHHHHHHHH	16.18	27642862
68	Methylation	LALKQELRGAMRQLP HHHHHHHHHHHHHCC	30.03	115488213
76	Phosphorylation	GAMRQLPYFIRPAVP HHHHHCCCHHCCCCC	21.89	-
93	Ubiquitination	DVERYSDKYQMSGPI HHHHHHHHCCCCCCC	31.29	21906983
130	Phosphorylation	KLQKERITILLPKRP HHHHHCEEEEECCCC	16.28	-
150	Ubiquitination	DKEETIQKLETLEKK CHHHHHHHHHHHHHH	44.43	-
156	2-Hydroxyisobutyrylation	QKLETLEKKEEEVTS HHHHHHHHHHHHCCC	69.47	-
162	Phosphorylation	EKKEEEVTSEEDEEK HHHHHHCCCHHHHHH	33.43	20164059
163	Phosphorylation	KKEEEVTSEEDEEKE HHHHHCCCHHHHHHH	44.13	28355574

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RPC7L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RPC7L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RPC7L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RPC6_HUMAN	POLR3F	physical	28514442
RPC8_HUMAN	POLR3H	physical	28514442
RPC5_HUMAN	POLR3E	physical	28514442
RPC3_HUMAN	POLR3C	physical	28514442
RPC2_HUMAN	POLR3B	physical	28514442
RPC4_HUMAN	POLR3D	physical	28514442
RPC9_HUMAN	CRCP	physical	28514442
RPC10_HUMAN	POLR3K	physical	28514442
RPC1_HUMAN	POLR3A	physical	28514442
RPAC1_HUMAN	POLR1C	physical	28514442
RPAB5_HUMAN	POLR2L	physical	28514442
OBSL1_HUMAN	OBSL1	physical	28514442
ACHA9_HUMAN	CHRNA9	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.