PKHG6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PKHG6_HUMAN
• UniProt AC: Q3KR16
• Protein Name: Pleckstrin homology domain-containing family G member 6
• Gene Name: PLEKHG6
• Organism: Homo sapiens (Human).
• Sequence Length: 790
• Subcellular Localization: Cell projection, microvillus . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, spindle pole . Cleavage furrow . During mitosis, localizes to the spindle pole, central spindle and cleavage furrow (PubMed:16721066). In epithelial cells, rec
• Protein Description: Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis..
• Protein Sequence: MKAFGPPHEGPLQGLVASRIETYGGRHRASAQSTAGRLYPRGYPVLDPSRRRLQQYVPFARGSGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPRLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRESPSTRPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTSDSGYGTLIPGTPTGSRSPLSRLRQRALRRDPRLTFSTLELRDIPLRPHPPDPQAPQRRSAPELPEGILKGGSLPQEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGESPWESSGEEEEEGPLFLKAGHTSLRPMRAEDMLREIREELASQRIEGAEEPRDSRPRKLTRAQLQRMRGPHIIQLDTPLSASEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Phosphorylation	GRLYPRGYPVLDPSR CCCCCCCCCCCCHHH	7.46	24719451
49	Phosphorylation	GYPVLDPSRRRLQQY CCCCCCHHHHHHHHH	37.78	24719451
56	Phosphorylation	SRRRLQQYVPFARGS HHHHHHHHCCCCCCC	9.34	-
67	Methylation	ARGSGQARGLSPMRL CCCCCCCCCCCCCCC	38.40	54558083
70	Phosphorylation	SGQARGLSPMRLRDP CCCCCCCCCCCCCCC	21.34	24719451
94	Phosphorylation	VGAGLLHSPKLKELT CCCHHCCCHHHHHHH	24.57	23312004
112	Phosphorylation	ELEVRLHTFSMFGMP HHCCEEEEEHHHCCC	23.23	-
114	Phosphorylation	EVRLHTFSMFGMPRL CCEEEEEHHHCCCCC	17.85	-
137	Phosphorylation	EIGEGGDSGLTIEKS CCCCCCCCCCEECHH	38.69	-
140	Phosphorylation	EGGDSGLTIEKSWRE CCCCCCCEECHHHHH	30.53	-
156	Phosphorylation	VPGHKEMSQELCHQQ CCCCHHHHHHHHHHH	22.92	24043423
171	Phosphorylation	EALWELLTTELIYVR HHHHHHHHHHHHHHH	30.74	24043423
172	Phosphorylation	ALWELLTTELIYVRK HHHHHHHHHHHHHHH	28.85	24043423
176	Phosphorylation	LLTTELIYVRKLKIM HHHHHHHHHHHHHHH	13.56	24043423
184	Phosphorylation	VRKLKIMTDLLAAGL HHHHHHHHHHHHHHH	27.28	22210691
204	Phosphorylation	VGLLMEVSAETLFGN HHHEEEECHHHHHCC	13.69	22210691
297	Phosphorylation	WCEKHKRSGRQMLCD HHHHHCCCHHHHHHH	43.03	-
316	Phosphorylation	PHQRITKYPLLLHAV CCHHHHHHHHHHHHH	7.17	-
434	Phosphorylation	DVYLFLFSDVLLVTK EEEEEEECCEEEECC	29.02	22210691
440	Phosphorylation	FSDVLLVTKPQRKAD ECCEEEECCCCCCCC	36.66	22210691
537	Phosphorylation	YRDQDRESPSTRPST HCCCCCCCCCCCCCC	25.66	28348404
539	Phosphorylation	DQDRESPSTRPSTPS CCCCCCCCCCCCCCC	46.45	28348404
540	Phosphorylation	QDRESPSTRPSTPSL CCCCCCCCCCCCCCC	50.40	26657352
543	Phosphorylation	ESPSTRPSTPSLEGS CCCCCCCCCCCCCCC	50.05	26657352
544	Phosphorylation	SPSTRPSTPSLEGSQ CCCCCCCCCCCCCCC	21.41	23312004
546	Phosphorylation	STRPSTPSLEGSQSS CCCCCCCCCCCCCCC	38.86	23312004
550	Phosphorylation	STPSLEGSQSSAEGR CCCCCCCCCCCCCCC	19.95	23312004
552	Phosphorylation	PSLEGSQSSAEGRTP CCCCCCCCCCCCCCC	32.96	23312004
553	Phosphorylation	SLEGSQSSAEGRTPE CCCCCCCCCCCCCCC	23.78	23312004
574	Phosphorylation	HLVVTEDTDEDAPLV EEEECCCCCCCCCCC	34.75	22817900
603	Phosphorylation	GTPTGSRSPLSRLRQ CCCCCCCCHHHHHHH	31.71	28348404
620	Phosphorylation	LRRDPRLTFSTLELR HHCCCCCCEEEEEEC	19.47	-
622	Phosphorylation	RDPRLTFSTLELRDI CCCCCCEEEEEECCC	27.18	28348404
623	Phosphorylation	DPRLTFSTLELRDIP CCCCCEEEEEECCCC	21.76	24719451
645	Phosphorylation	PQAPQRRSAPELPEG CCCCCCCCCCCCCCC	50.82	26657352
666	Phosphorylation	LPQEDPPTWSEEEDG CCCCCCCCCCCCCCC	47.19	28348404
668	Phosphorylation	QEDPPTWSEEEDGAS CCCCCCCCCCCCCCC	37.29	26657352
675	Phosphorylation	SEEEDGASERGNVVV CCCCCCCCCCCCEEE	33.10	25841592
696	Phosphorylation	RLRGQLPSSPTHADS HHCCCCCCCCCCCCC	58.50	21406692
697	Phosphorylation	LRGQLPSSPTHADSA HCCCCCCCCCCCCCC	31.70	21406692
699	Phosphorylation	GQLPSSPTHADSAGE CCCCCCCCCCCCCCC	31.48	21406692
703	Phosphorylation	SSPTHADSAGESPWE CCCCCCCCCCCCCCC	38.67	21406692
707	Phosphorylation	HADSAGESPWESSGE CCCCCCCCCCCCCCC	34.10	21406692
711	Phosphorylation	AGESPWESSGEEEEE CCCCCCCCCCCCCCC	39.51	21406692
712	Phosphorylation	GESPWESSGEEEEEG CCCCCCCCCCCCCCC	38.41	28290473
729	Phosphorylation	FLKAGHTSLRPMRAE EEECCCCCCCCCCHH	19.39	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
540	T	Phosphorylation	Kinase	AURB	Q96GD4	PSP
543	S	Phosphorylation	Kinase	AURB	Q96GD4	PSP
544	T	Phosphorylation	Kinase	AURB	Q96GD4	PSP
546	S	Phosphorylation	Kinase	AURB	Q96GD4	PSP
574	T	Phosphorylation	Kinase	PLK1	P53350	PSP
620	T	Phosphorylation	Kinase	AURB	Q96GD4	PSP
645	S	Phosphorylation	Kinase	AURB	Q96GD4	PSP
697	S	Phosphorylation	Kinase	AURB	Q96GD4	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PKHG6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PKHG6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PCDG5_HUMAN	PCDHGA5	physical	28514442
BPIA2_HUMAN	BPIFA2	physical	28514442
CYTN_HUMAN	CST1	physical	28514442
CARME_HUMAN	C9orf41	physical	28514442
CYTD_HUMAN	CST5	physical	28514442
PIGR_HUMAN	PIGR	physical	28514442
IGJ_HUMAN	IGJ	physical	28514442
ZG16B_HUMAN	ZG16B	physical	28514442
GELS_HUMAN	GSN	physical	28514442
ACTB_HUMAN	ACTB	physical	28514442
ACTA_HUMAN	ACTA2	physical	28514442
LIMA1_HUMAN	LIMA1	physical	28514442
TMOD2_HUMAN	TMOD2	physical	28514442
IKIP_HUMAN	IKBIP	physical	28514442
TMOD1_HUMAN	TMOD1	physical	28514442
CYTS_HUMAN	CST4	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.