PCDB7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCDB7_HUMAN
• UniProt AC: Q9Y5E2
• Protein Name: Protocadherin beta-7
• Gene Name: PCDHB7
• Organism: Homo sapiens (Human).
• Sequence Length: 793
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.
• Protein Description: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain..
• Protein Sequence: MEARVERAVQKRQVLFLCVFLGMSWAGAEPLRYFVAEETERGTFLTNLAKDLGLGVGELRARGTRIVSDQNMQILLLSSLTGDLLLNEKLDREELCGPREPCVLPFQLLLEKPFQIFRAELWVRDINDHAPVFLDREISLKILESTTPGAAFLLESAQDSDVGTNSLSNYTISPNAYFHINVHDSGEGNIYPELVLNQVLDREEIPEFSLTLTALDGGSPPRSGTALVRILVLDVNDNAPDFVRSLYKVQVPENSPVGSMVVSVSARDLDTGSNGEIAYAFSYATERILKTFQINPTSGSLHLKAQLDYEAIQTYTLTIQAKDGGGLSGKCTVVVDVTDINDNRPELLLSSLTSPIAENSPETVVAVFRIRDRDSGNNGKTVCSIQDDVPFILKPSVENFYTLVTEKPLDRERNTEYNITITVTDLGTPRLKTEHNITVLVSDVNDNAPAFTQTSYTLFVRENNSPALPIGSVSATDRDSGTNAQVIYSLLPSQDPHLPLASLVSINADNGHLFALRSLDYEALQAFEFRVGATDRGSPALSSEALVRVLVLDANDNSPFVLYPLQNSSAPCTEPLPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKQRLVVLVKDNGEPPRSATATLHVLLVDGFSQPYLRLPEAAPDQANSLTVYLVVALASVSSLFLLSVLLFVAVRLCRRSRAAPVGRCSVPEGPFPRHLVDLSGTGTLSQSYQYEVCLTGGSGTNEFKFLKPIIPNLLPQSTGREVEENRPFQNNLGF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
79	Phosphorylation	MQILLLSSLTGDLLL HEEEEHHHHCCCHHH	29.89	22210691
169	N-linked_Glycosylation	VGTNSLSNYTISPNA CCCCCCCCEEECCCE	43.17	UniProtKB CARBOHYD
223	Phosphorylation	DGGSPPRSGTALVRI CCCCCCCCCCEEEEE	46.39	23403867
225	Phosphorylation	GSPPRSGTALVRILV CCCCCCCCEEEEEEE	20.33	23403867
245	Phosphorylation	NAPDFVRSLYKVQVP CCCHHHHHHEEEECC	30.65	27174698
247	Phosphorylation	PDFVRSLYKVQVPEN CHHHHHHEEEECCCC	15.45	27174698
255	Phosphorylation	KVQVPENSPVGSMVV EEECCCCCCCCEEEE	21.21	27174698
259	Phosphorylation	PENSPVGSMVVSVSA CCCCCCCEEEEEEEE	14.50	27174698
263	Phosphorylation	PVGSMVVSVSARDLD CCCEEEEEEEEEECC	10.03	27174698
265	Phosphorylation	GSMVVSVSARDLDTG CEEEEEEEEEECCCC	15.30	27174698
291	Phosphorylation	ATERILKTFQINPTS HHHHHHHHEEECCCC	19.82	30243723
297	Phosphorylation	KTFQINPTSGSLHLK HHEEECCCCCCEEEE	41.03	30243723
298	Phosphorylation	TFQINPTSGSLHLKA HEEECCCCCCEEEEE	27.86	30243723
300	Phosphorylation	QINPTSGSLHLKAQL EECCCCCCEEEEEEE	16.63	30243723
309	Phosphorylation	HLKAQLDYEAIQTYT EEEEEECCCEEEEEE	18.82	-
314	Phosphorylation	LDYEAIQTYTLTIQA ECCCEEEEEEEEEEE	16.62	17322306
318	Phosphorylation	AIQTYTLTIQAKDGG EEEEEEEEEEEECCC	11.84	-
418	N-linked_Glycosylation	RERNTEYNITITVTD CCCCCEEEEEEEEEC	20.77	UniProtKB CARBOHYD
428	Phosphorylation	ITVTDLGTPRLKTEH EEEECCCCCCCCCCC	16.72	22817900
436	N-linked_Glycosylation	PRLKTEHNITVLVSD CCCCCCCCEEEEEEC	25.95	UniProtKB CARBOHYD
567	N-linked_Glycosylation	FVLYPLQNSSAPCTE EEEEEECCCCCCCCC	45.69	UniProtKB CARBOHYD
715	Phosphorylation	AVRLCRRSRAAPVGR HHHHHHHCCCCCCCC	13.61	-
763	Ubiquitination	GSGTNEFKFLKPIIP CCCCCCEEECCCCCC	43.54	23000965
766	Ubiquitination	TNEFKFLKPIIPNLL CCCEEECCCCCCCCC	36.98	23000965

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCDB7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCDB7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCDB7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PCDBC_HUMAN	PCDHB12	physical	28514442
CA043_HUMAN	C1orf43	physical	28514442
ST7L_HUMAN	ST7L	physical	28514442
C2C2L_HUMAN	C2CD2L	physical	28514442
POMT1_HUMAN	POMT1	physical	28514442
USE1_HUMAN	USE1	physical	28514442
PIGA_HUMAN	PIGA	physical	28514442
PDZD8_HUMAN	PDZD8	physical	28514442
RN149_HUMAN	RNF149	physical	28514442
K319L_HUMAN	KIAA0319L	physical	28514442
CISD2_HUMAN	CISD2	physical	28514442
NSMA_HUMAN	SMPD2	physical	28514442
GRM1A_HUMAN	GRAMD1A	physical	28514442
SUN2_HUMAN	SUN2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.