| UniProt ID | PCDBC_HUMAN | |
|---|---|---|
| UniProt AC | Q9Y5F1 | |
| Protein Name | Protocadherin beta-12 | |
| Gene Name | PCDHB12 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 795 | |
| Subcellular Localization |
Cell membrane Single-pass type I membrane protein. |
|
| Protein Description | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.. | |
| Protein Sequence | MENGGAGTLQIRQVLLFFVLLGMSQAGSETGNFLVMEELQSGSFVGNLAKTLGLEVSELSSRGARVVSNDNKECLQLDTNTGDLLLREMLDREELCGSNEPCVLYFQVLMKNPTQFLQIELQVRDINDHSPVFLEKEMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYTINPNSHFHVKIRVNPDNRKYPELVLDKALDYEERPELSFILTALDGGSPPRSGTALVRVVVVDINDNSPEFEQAFYEVKILENSILGSLVVTVSAWDLDSGTNSELSYTFSHASEDIRKTFEINQKSGDITLTAPLDFEAIESYSIIIQATDGGGLFGKSTVRIQVMDVNDNAPEITVSSITSPIPENTPETVVMVFRIRDRDSGDNGKMVCSIPEDIPFVLKSSVNNYYTLETERPLDRESRAEYNITITVTDLGTPRLKTEHNITVLVSDVNDNAPAFTQTSYALFVRENNSPALHIGSISATDRDSGTNAQVNYSLLPSQDPHLPLASLVSINADNGHLFALRSLDYEALQGFQFRVGATDHGSPALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPWAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVDGFSQPYLPLPEAAPAQAQADSLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAAPVGRCSVPEGPFPGHLVDVSGTGTLSQSYHYEVCVTGGSRSNKFKFLKPIIPNFLPQSTGSEVEENPPFQNNLGF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 8 | Phosphorylation | MENGGAGTLQIRQVL CCCCCCCHHHHHHHH | 18.24 | 22210691 | |
| 68 | Phosphorylation | SRGARVVSNDNKECL HCCCEEECCCCCCEE | 35.29 | - | |
| 105 | Phosphorylation | SNEPCVLYFQVLMKN CCCCEEEEEEEEECC | 3.30 | - | |
| 223 | Phosphorylation | DGGSPPRSGTALVRV CCCCCCCCCCEEEEE | 46.39 | 23403867 | |
| 225 | Phosphorylation | GSPPRSGTALVRVVV CCCCCCCCEEEEEEE | 20.33 | 23403867 | |
| 247 | Phosphorylation | PEFEQAFYEVKILEN HHHHHHHHHHHHHHC | 23.87 | 22817900 | |
| 413 | Phosphorylation | ERPLDRESRAEYNIT CCCCCCCCCCEEEEE | 37.37 | 18669648 | |
| 418 | N-linked_Glycosylation | RESRAEYNITITVTD CCCCCEEEEEEEEEC | 19.21 | UniProtKB CARBOHYD | |
| 420 | Phosphorylation | SRAEYNITITVTDLG CCCEEEEEEEEECCC | 13.63 | 18669648 | |
| 428 | Phosphorylation | ITVTDLGTPRLKTEH EEEECCCCCCCCCCC | 16.72 | 18669648 | |
| 436 | N-linked_Glycosylation | PRLKTEHNITVLVSD CCCCCCCCEEEEEEC | 25.95 | UniProtKB CARBOHYD | |
| 487 | N-linked_Glycosylation | SGTNAQVNYSLLPSQ CCCCCEEEEECCCCC | 14.48 | UniProtKB CARBOHYD | |
| 567 | N-linked_Glycosylation | FVLYPLQNGSAPCTE EEEEECCCCCCCCCC | 54.81 | UniProtKB CARBOHYD | |
| 717 | Phosphorylation | AVRLCRRSRAAPVGR HHHHHHHCCCCCCCC | 13.61 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PCDBC_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PCDBC_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PCDBC_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PCDBC_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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