PAPS4_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PAPS4_ARATH
• UniProt AC: Q8VYW1
• Protein Name: Nuclear poly(A) polymerase 4 {ECO:0000303|PubMed:18479511}
• Gene Name: PAPS4 {ECO:0000303|PubMed:18479511}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 741
• Subcellular Localization: Nucleus .
• Protein Description: Essential protein. [PubMed: 19956626 Polymerase that creates the 3'-poly(A) tail of mRNA's]
• Protein Sequence: MMVGTQNLGGSLPPLNSPKSYGITKPLSLAGPSSADIKRNVELEKYLVDEGLYESKDDTMRREEVLGRIDQIVKHWVKQLTQQRGYTDQMVEDANAVIFTFGSYRLGVHGPGADIDTLCVGPSYVNREEDFFIILHDILAEMEEVTELHPVPDAHVPVMKFKFQGIPIDLLYASISLLVVPQDLDISSSSVLCEVDEPTVRSLNGCRVADQILKLVPNFEHFRTTLRCLKYWAKKRGVYSNVTGFLGGVNWALLVARVCQLYPNAIPSMLVSRFFRVYTQWRWPNPVMLCAIEEDELGFPVWDRRKNHRDRYHLMPIITPAYPCMNSSYNVSQSTLRVMTEQFQFGNNILQEIELNKQHWSSLFEQYMFFEAYKNYLQVDIVAADAEDLLAWKGWVESRFRQLTLKIERDTNGMLMCHPQPNEYVDTARQFLHCAFFMGLQRAEGVGGQECQQFDIRGTVDEFRQEVNMYMFWKPGMDVFVSHVRRRQLPPFVFPNGYRRPRQSRHQNLPGGKSGEDGSVSHSGSVVERHAKRKNDSEMMDVRPEKPEKRASLSPQSLDIVSPENSAITTGWTPPVCNLRRPPSEEIEADNLNTECTELTDLARNECNSGSEQVLEVDSMAVVQECSDPAEPLGKCVTPDSVDVVACVSGQEENLDRNLRSVSISGTDSPLLPSRSCGQNRDYEGFGFPAANSDPMGKKNLYSQSGMSEDLQSNSLVSGMEKSEDRARSESFQKSQIRLLT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
55	Phosphorylation	VDEGLYESKDDTMRR HHCCCCCCCCCHHCH		24243849
519	Phosphorylation	GKSGEDGSVSHSGSV CCCCCCCCCCCCCCH		30407730
521	Phosphorylation	SGEDGSVSHSGSVVE CCCCCCCCCCCCHHH		30407730
523	Phosphorylation	EDGSVSHSGSVVERH CCCCCCCCCCHHHHH		30407730
525	Phosphorylation	GSVSHSGSVVERHAK CCCCCCCCHHHHHHC		30407730
584	Phosphorylation	CNLRRPPSEEIEADN CCCCCCCHHHHCCCC		19880383
667	Phosphorylation	RSVSISGTDSPLLPS CEEEECCCCCCCCCC		23776212
669	Phosphorylation	VSISGTDSPLLPSRS EEECCCCCCCCCCCC		30291188
674	Phosphorylation	TDSPLLPSRSCGQNR CCCCCCCCCCCCCCC		23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PAPS4_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PAPS4_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PAPS4_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CPSF2_ARATH	CPSF100	physical	12602868
GEML1_ARATH	FIP1	physical	16282318
PAPS1_ARATH	PAPS1	physical	18479511
FIPS3_ARATH	AT3G66652	physical	18479511
FIPS5_ARATH	FIP1[V]	physical	18479511
GATL4_ARATH	GATL4	physical	18479511
PABN2_ARATH	AT5G65260	physical	18479511

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.