FIPS5_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FIPS5_ARATH
• UniProt AC: F4KDH9
• Protein Name: FIP1[V]-like protein {ECO:0000303|PubMed:16282318}
• Gene Name: FIPS5 {ECO:0000303|PubMed:16282318}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1196
• Subcellular Localization: Nucleus .
• Protein Description: Essential gene. [PubMed: 16282318 Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex (By similarity]
• Protein Sequence: MEEDDEFGDLYSDVLQPFQPPVVLPPPPPLPHRSIDLNLRSQDQDVSEPNSAPISRVSDNDAVKLSTQDATRQAIVDGGGDDKDMSFDIEEPDADSTPTIPGLFVTGALPGLATDRGVSQVTTRIEQQVGGGGDGGYGGQGEGDDWDSDSEDDLQIVLNDSSRNVMIGGADRRSRMGDNEDDDDEDDEDPLVIVADTDPNQPMEEQMWGEDGLQGIEGDGKDGGEAGKGSGPGGATGPPKAGYSSHGYHPFHSQFKYVRPGAAPIPGGAASVGGPSSGQVRPPANLGPMAGRGRGDWRPLGMRNASAAQKGFHQPWGSNTAGRGLDFTLPSHKTIFEVDIDSFEEKPWRYPGVEMTDYFNFGLNEESWKDYCKQLDQHRIQTTMQSRIRVYESGRTDQGYDPDLPPELAAATGAQGVPVDSSNLVKPDSVQGDSAKVPANVRPTLPPGRPIPVETGSGERLPSIDTRAPRMRDLDAIIEIVCQDSHEDEPSGENGTDQADSSLPGENVPVETSYVNNKRPDTESAEHSPAQDEPHKNLLKKQDDEISRSTDSGQSFRSSSPVGDRGTRSSSVDREDVGGEAGKDAEMGEELKMSFTSPQSAVQEDDGGESKTERSSESSKARSGSHRDFQQEEDVIQDKHSSRPANNRKQYDNNAPHQSRKNQDRGKEMERTRAASKGGRENSNPHMELDSTYIYSIASREDFDKRKERDVDGAVWRRKEDDPYSRRGGDEGSRKRDREDDPGFRQRGKMRENEIRSKDDQVPSRKHMDDAGMRNIYEPDDHINKRRKDEEYLRRSRPEKNEISYGQRESMSRVKRERDDRLEHQKRDVQHKIRDDFDDHGSLRQRDDIYMQRDGNERLRERDVLDKLKLPHEDGISARGRERQVAVRGHRGSEDRSSRMKDEYKASDKEHVTKDTLRHAKQTKRRDYPGEESSSHHRGHEDFSARTDNIVNNEKKPRQERTGAKIDKFIDTLDGQRLQDRKHKDSRRKIKEQREGTESLSKQGEQNGSSVVTGSKGTNDARNCRSEIPHQPNTAKRHKENASSGDEIHDSKRGRTKLERWASHKEREDAVSAKSSSISSKLEEKENNTNGRLSEPVHGSIGKSRDVTEEKIGHDLADTKDGSEKGPGDRHLDTVEKLKKRSERFKLPMPTEKDTTGVKKMESETLPSAKIEGPVDSEGEYVWDERSCVRIGREYA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47	Phosphorylation	RSQDQDVSEPNSAPI CCCCCCCCCCCCCCC		26658240
148	Phosphorylation	GEGDDWDSDSEDDLQ CCCCCCCCCCCCCEE		27531888
150	Phosphorylation	GDDWDSDSEDDLQIV CCCCCCCCCCCEEEE		27531888
522	Phosphorylation	VNNKRPDTESAEHSP CCCCCCCCCCCCCCC		23776212
524	Phosphorylation	NKRPDTESAEHSPAQ CCCCCCCCCCCCCCC		23776212
528	Phosphorylation	DTESAEHSPAQDEPH CCCCCCCCCCCCCHH		23776212
569	Phosphorylation	VGDRGTRSSSVDRED CCCCCCCCCCCCHHH		23776212
570	Phosphorylation	GDRGTRSSSVDREDV CCCCCCCCCCCHHHC		23776212
571	Phosphorylation	DRGTRSSSVDREDVG CCCCCCCCCCHHHCC		23776212
594	Phosphorylation	MGEELKMSFTSPQSA HCHHEEEEECCCCCC		25561503
596	Phosphorylation	EELKMSFTSPQSAVQ HHEEEEECCCCCCCC		19880383
597	Phosphorylation	ELKMSFTSPQSAVQE HEEEEECCCCCCCCC		27531888
600	Phosphorylation	MSFTSPQSAVQEDDG EEECCCCCCCCCCCC		30407730
615	Phosphorylation	GESKTERSSESSKAR CCCCCCCCCCCCCCC		25561503
618	Phosphorylation	KTERSSESSKARSGS CCCCCCCCCCCCCCC		25561503
623	Phosphorylation	SESSKARSGSHRDFQ CCCCCCCCCCCCCHH		25561503
625	Phosphorylation	SSKARSGSHRDFQQE CCCCCCCCCCCHHHH		19880383
997	Phosphorylation	IKEQREGTESLSKQG HHHHHHHHHHHHHHC		25561503
999	Phosphorylation	EQREGTESLSKQGEQ HHHHHHHHHHHHCCC		25561503
1009	Phosphorylation	KQGEQNGSSVVTGSK HHCCCCCCCEECCCC		23776212
1010	Phosphorylation	QGEQNGSSVVTGSKG HCCCCCCCEECCCCC		23776212
1013	Phosphorylation	QNGSSVVTGSKGTND CCCCCEECCCCCCCC		23776212
1015	Phosphorylation	GSSVVTGSKGTNDAR CCCEECCCCCCCCCC		23776212
1018	Phosphorylation	VVTGSKGTNDARNCR EECCCCCCCCCCCCH		23776212
1043	Phosphorylation	KRHKENASSGDEIHD HHHHHHCCCCCCCCC		30407730
1044	Phosphorylation	RHKENASSGDEIHDS HHHHHCCCCCCCCCC		30407730
1051	Phosphorylation	SGDEIHDSKRGRTKL CCCCCCCCHHCHHHH		30407730
1100	Phosphorylation	LSEPVHGSIGKSRDV CCCCCCCCCCCCCCC		25561503
1108	Phosphorylation	IGKSRDVTEEKIGHD CCCCCCCCHHHHCCC		19880383
1123	Phosphorylation	LADTKDGSEKGPGDR CCCCCCCCCCCCCCH		19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FIPS5_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FIPS5_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FIPS5_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CTF64_ARATH	CSTF64	physical	18479511
PAPS3_ARATH	PAPS3	physical	18479511
FIPS3_ARATH	AT3G66652	physical	18479511
CFIS1_ARATH	CFIM-25	physical	18479511
PABN1_ARATH	PABN1	physical	18479511
PABN2_ARATH	AT5G65260	physical	18479511
PABN3_ARATH	AT5G10350	physical	18479511
CPSF_ARATH	CPSF30	physical	17576667

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.