dbPTM

FIPS3_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FIPS3_ARATH
UniProt AC	F4JC20
Protein Name	FIP1[III]-like protein {ECO:0000303\|PubMed:16282318}
Gene Name	FIPS3 {ECO:0000303\|PubMed:16282318}
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	997
Subcellular Localization	Nucleus .
Protein Description	Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex..
Protein Sequence	MDSTDDDFGDLYVDDAKFQATDAFESECATNSGEDKGFEETVKSDSEGEVKKFDVVAKDSSPCDDDDCAMNLTEADEESEFSDSDDDLNIVLKDDDSKALPASCVFNTNFGGYEASKASSFQRRWTRNASANNACIDPSLGMSQYRYSFPNPWSRTPFDVNLDVLEKKPWRDPGTDTSDFFNFGLNEQSWKDYCKPLGRAIEVRGGTLERIPSADLRRPRDPDPGVVIQIPVTNDVEELPVRTPEKARCITSNEASRSDVSHSYGSKDLNSVYGSPKDEAFVGCQEENAGSFSGEKSLPTENCCSREATPSDKEMLEKEKEESVCNSDETDPSSVERESSLGDRIRLSPTSSSSVGINEESDDYETESLKDSATDDQREVSTPPQEARLAEHEAISIKRGEDSGTMHSRHRRSHEDSSKRHCGRAGYARYVKDASPTPDPGRGKKVGSLQGLYRDSNKNWQNGPPITLERDETEGKGVHYYREKSHGRLNSSVDHDRHREHRFGWRNNKESSLGRGFDHSNSYKCGTHLKEYTSRSSFDLNQRNSRSSFKEEDDRYGWHHRERKYVHERSPIRAYENYKERNGCDWLREPYYEDCIPITDMDYRYRSENSSAHAIHNLKHSPENDLYCRRRGGYDYNLHRDRYEDGVHRVESRIPFELAYREMRSFAEVEMREYQGYKRHEEFSEIEKRHHYIHDWHLDRFVSEEDGYKYRIQDGWSSPSLSLRDSWYTKEAKGDFRRDDTRDFRTPEAYDSQNNHFHKAAPRDGWTQNLGRSHNVSVKDRLQYDADWVGPDRGRYNMADDMQCSMREVSNSEHPSYTDEIFVRDIRVPTHNRMATKQRFGYLQSHIHENDERHHRSKKLRGDGHAFIKRQDHVDLAGRQGKVSNQSKKRFSNGGDTIEQQDVQKPRKLMGKSEEKAMQNRDINDKEEGEIIEEVKGVEIDNERIQESLKKMEKRRERFKGTKLAVEATFKSQTELRAKADVTNQQRPVRKRRWCAS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
251	Phosphorylation	PEKARCITSNEASRS CCCCEEEECCCCCCC	19880383
252	Phosphorylation	EKARCITSNEASRSD CCCEEEECCCCCCCC	19880383
435	Phosphorylation	ARYVKDASPTPDPGR HEECCCCCCCCCCCC	26658240
717	Phosphorylation	YRIQDGWSSPSLSLR EEECCCCCCCCCCCC	19880383
718	Phosphorylation	RIQDGWSSPSLSLRD EECCCCCCCCCCCCC	19880383
720	Phosphorylation	QDGWSSPSLSLRDSW CCCCCCCCCCCCCCC	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of FIPS3_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FIPS3_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FIPS3_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of FIPS3_ARATH !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FIPS3_ARATH

Related Literatures of Post-Translational Modification