dbPTM

PAPS1_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PAPS1_ARATH
UniProt AC	Q9LMT2
Protein Name	Nuclear poly(A) polymerase 1 {ECO:0000303\|PubMed:18479511}
Gene Name	PAPS1 {ECO:0000303\|PubMed:18479511}
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	713
Subcellular Localization	Nucleus .
Protein Description	Essential protein. [PubMed: 19956626 Polymerase that creates the 3'-poly(A) tail of mRNA's]
Protein Sequence	MASVQQNGQRFGVSEPISMGGPTEFDVIKTRELEKHLQDVGLYESKEEAVRREEVLGILDQIVKTWIKTISRAKGLNDQLLHEANAKIFTFGSYRLGVHGPGADIDTLCVGPRHATREGDFFGELQRMLSEMPEVTELHPVPDAHVPLMGFKLNGVSIDLLYAQLPLWVIPEDLDLSQDSILQNADEQTVRSLNGCRVTDQILRLVPNIQNFRTTLRCMRFWAKRRGVYSNVSGFLGGINWALLVARICQLYPNALPNILVSRFFRVFYQWNWPNAIFLCSPDEGSLGLQVWDPRINPKDRLHIMPIITPAYPCMNSSYNVSESTLRIMKGEFQRGNEICEAMESNKADWDTLFEPFAFFEAYKNYLQIDISAANVDDLRKWKGWVESRLRQLTLKIERHFKMLHCHPHPHDFQDTSRPLHCSYFMGLQRKQGVPAAEGEQFDIRRTVEEFKHTVNAYTLWIPGMEISVGHIKRRSLPNFVFPGGVRPSHTSKGTWDSNRRSEHRNSSTSSAPAATTTTTEMSSESKAGSNSPVDGKKRKWGDSETLTDQPRNSKHIAVSVPVENCEGGSPNPSVGSICSSPMKDYCTNGKSEPISKDPPENVVAFSKDPPESLPIEKIATPQAHETEELEESFDFGNQVIEQISHKVAVLSATATIPPFEATSNGSPFPYEAVEELEVLPTRQPDAAHRPSVQQRKPIIKLSFTSLGKTNGK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
511	Phosphorylation	HRNSSTSSAPAATTT CCCCCCCCCCCCCCC	23111157
516	Phosphorylation	TSSAPAATTTTTEMS CCCCCCCCCCCCCCC	23111157
517	Phosphorylation	SSAPAATTTTTEMSS CCCCCCCCCCCCCCC	30407730
518	Phosphorylation	SAPAATTTTTEMSSE CCCCCCCCCCCCCCC	30407730
519	Phosphorylation	APAATTTTTEMSSES CCCCCCCCCCCCCCC	30407730
520	Phosphorylation	PAATTTTTEMSSESK CCCCCCCCCCCCCCC	30407730
523	Phosphorylation	TTTTTEMSSESKAGS CCCCCCCCCCCCCCC	19880383
524	Phosphorylation	TTTTEMSSESKAGSN CCCCCCCCCCCCCCC	23111157
526	Phosphorylation	TTEMSSESKAGSNSP CCCCCCCCCCCCCCC	30407730
530	Phosphorylation	SSESKAGSNSPVDGK CCCCCCCCCCCCCCC	23776212
532	Phosphorylation	ESKAGSNSPVDGKKR CCCCCCCCCCCCCCC	23776212
570	Phosphorylation	VENCEGGSPNPSVGS EECCCCCCCCCCHHH	23111157
581	Phosphorylation	SVGSICSSPMKDYCT CHHHCCCCCCCCCCC	23111157
621	Phosphorylation	LPIEKIATPQAHETE CCHHHCCCCCCCCCH	23776212
627	Phosphorylation	ATPQAHETEELEESF CCCCCCCCHHHHHHH	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PAPS1_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PAPS1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PAPS1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PAPS1_ARATH !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PAPS1_ARATH

Related Literatures of Post-Translational Modification