CPSF2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CPSF2_ARATH
• UniProt AC: Q9LKF9
• Protein Name: Cleavage and polyadenylation specificity factor subunit 2
• Gene Name: CPSF100
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 739
• Subcellular Localization: Nucleus . Cytoplasm . Localized in the cytoplasm when associated with CPSF30.
• Protein Description: CPSF plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A)polymerase and other factors to bring about cleavage and poly(A) addition (By similarity). Required for antisense-RNA-mediated gene silencing. [PubMed: 17008405]
• Protein Sequence: MGTSVQVTPLCGVYNENPLSYLVSIDGFNFLIDCGWNDLFDTSLLEPLSRVASTIDAVLLSHPDTLHIGALPYAMKQLGLSAPVYATEPVHRLGLLTMYDQFLSRKQVSDFDLFTLDDIDSAFQNVIRLTYSQNYHLSGKGEGIVIAPHVAGHMLGGSIWRITKDGEDVIYAVDYNHRKERHLNGTVLQSFVRPAVLITDAYHALYTNQTARQQRDKEFLDTISKHLEVGGNVLLPVDTAGRVLELLLILEQHWSQRGFSFPIYFLTYVSSSTIDYVKSFLEWMSDSISKSFETSRDNAFLLRHVTLLINKTDLDNAPPGPKVVLASMASLEAGFAREIFVEWANDPRNLVLFTETGQFGTLARMLQSAPPPKFVKVTMSKRVPLAGEELIAYEEEQNRLKREEALRASLVKEEETKASHGSDDNSSEPMIIDTKTTHDVIGSHGPAYKDILIDGFVPPSSSVAPMFPYYDNTSEWDDFGEIINPDDYVIKDEDMDRGAMHNGGDVDGRLDEATASLMLDTRPSKVMSNELIVTVSCSLVKMDYEGRSDGRSIKSMIAHVSPLKLVLVHAIAEATEHLKQHCLNNICPHVYAPQIEETVDVTSDLCAYKVQLSEKLMSNVIFKKLGDSEVAWVDSEVGKTERDMRSLLPMPGAASPHKPVLVGDLKIADFKQFLSSKGVQVEFAGGGALRCGEYVTLRKVGPTGQKGGASGPQQILIEGPLCEDYYKIRDYLYSQFYLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
109	Phosphorylation	FLSRKQVSDFDLFTL HHHCCCCCCCCCEEH	30.02	23776212
115	Phosphorylation	VSDFDLFTLDDIDSA CCCCCCEEHHHHCHH	36.25	23776212
121	Phosphorylation	FTLDDIDSAFQNVIR EEHHHHCHHHHHHHH	31.17	23776212
130	Phosphorylation	FQNVIRLTYSQNYHL HHHHHHHEECCCEEE	15.98	23776212
131	Phosphorylation	QNVIRLTYSQNYHLS HHHHHHEECCCEEEC	16.92	23776212
132	Phosphorylation	NVIRLTYSQNYHLSG HHHHHEECCCEEECC	13.50	23776212
135	Phosphorylation	RLTYSQNYHLSGKGE HHEECCCEEECCCCC	9.12	23776212
138	Phosphorylation	YSQNYHLSGKGEGIV ECCCEEECCCCCCEE	25.75	23776212
419	Phosphorylation	KEEETKASHGSDDNS CHHHHHHCCCCCCCC	29.91	23776212
422	Phosphorylation	ETKASHGSDDNSSEP HHHHCCCCCCCCCCC	36.05	23776212
426	Phosphorylation	SHGSDDNSSEPMIID CCCCCCCCCCCEEEE	42.97	23776212
427	Phosphorylation	HGSDDNSSEPMIIDT CCCCCCCCCCEEEEC	52.56	23776212
655	Phosphorylation	LPMPGAASPHKPVLV CCCCCCCCCCCCEEE	27.31	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CPSF2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CPSF2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CPSF2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CPSF2_ARATH	CPSF100	physical	16897494
CPSF_ARATH	CPSF30	physical	16897494
CPSF1_ARATH	CPSF160	physical	16897494
CPSF3_ARATH	CPSF73-I	physical	16897494
CPS3B_ARATH	CPSF73-II	physical	16897494
FY_ARATH	FY	physical	17008405
CPSF1_ARATH	CPSF160	physical	17008405
CPSF3_ARATH	CPSF73-I	physical	17008405
PAPS4_ARATH	nPAP	physical	12602868
CPS3B_ARATH	CPSF73-II	physical	19748916
CPSF3_ARATH	CPSF73-I	physical	19748916
CPSF2_ARATH	CPSF100	physical	19748916
CPSF1_ARATH	CPSF160	physical	19748916
FY_ARATH	FY	physical	19748916
CPSF_ARATH	CPSF30	physical	19748916
CPSF1_ARATH	CPSF160	physical	18479511
CPSF3_ARATH	CPSF73-I	physical	18479511
CPS3B_ARATH	CPSF73-II	physical	18479511
CTF50_ARATH	AT5G60940	physical	18479511
FY_ARATH	FY	physical	18479511
PAPS2_ARATH	PAPS2	physical	18479511

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.