CPSF1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CPSF1_ARATH
• UniProt AC: Q9FGR0
• Protein Name: Cleavage and polyadenylation specificity factor subunit 1
• Gene Name: CPSF160
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1442
• Subcellular Localization: Nucleus .
• Protein Description: CPSF plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A)polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction..
• Protein Sequence: MSFAAYKMMHWPTGVENCASGYITHSLSDSTLQIPIVSVHDDIEAEWPNPKRGIGPLPNVVITAANILEVYIVRAQEEGNTQELRNPKLAKRGGVMDGVYGVSLELVCHYRLHGNVESIAVLPMGGGNSSKGRDSIILTFRDAKISVLEFDDSIHSLRMTSMHCFEGPDWLHLKRGRESFPRGPLVKVDPQGRCGGVLVYGLQMIILKTSQVGSGLVGDDDAFSSGGTVSARVESSYIINLRDLEMKHVKDFVFLHGYIEPVIVILQEEEHTWAGRVSWKHHTCVLSALSINSTLKQHPVIWSAINLPHDAYKLLAVPSPIGGVLVLCANTIHYHSQSASCALALNNYASSADSSQELPASNFSVELDAAHGTWISNDVALLSTKSGELLLLTLIYDGRAVQRLDLSKSKASVLASDITSVGNSLFFLGSRLGDSLLVQFSCRSGPAASLPGLRDEDEDIEGEGHQAKRLRMTSDTFQDTIGNEELSLFGSTPNNSDSAQKSFSFAVRDSLVNVGPVKDFAYGLRINADANATGVSKQSNYELVCCSGHGKNGALCVLRQSIRPEMITEVELPGCKGIWTVYHKSSRGHNADSSKMAADEDEYHAYLIISLEARTMVLETADLLTEVTESVDYYVQGRTIAAGNLFGRRRVIQVFEHGARILDGSFMNQELSFGASNSESNSGSESSTVSSVSIADPYVLLRMTDDSIRLLVGDPSTCTVSISSPSVLEGSKRKISACTLYHDKGPEPWLRKASTDAWLSSGVGEAVDSVDGGPQDQGDIYCVVCYESGALEIFDVPSFNCVFSVDKFASGRRHLSDMPIHELEYELNKNSEDNTSSKEIKNTRVVELAMQRWSGHHTRPFLFAVLADGTILCYHAYLFDGVDSTKAENSLSSENPAALNSSGSSKLRNLKFLRIPLDTSTREGTSDGVASQRITMFKNISGHQGFFLSGSRPGWCMLFRERLRFHSQLCDGSIAAFTVLHNVNCNHGFIYVTAQGVLKICQLPSASIYDNYWPVQKIPLKATPHQVTYYAEKNLYPLIVSYPVSKPLNQVLSSLVDQEAGQQLDNHNMSSDDLQRTYTVEEFEIQILEPERSGGPWETKAKIPMQTSEHALTVRVVTLLNASTGENETLLAVGTAYVQGEDVAARGRVLLFSFGKNGDNSQNVVTEVYSRELKGAISAVASIQGHLLISSGPKIILHKWNGTELNGVAFFDAPPLYVVSMNVVKSFILLGDVHKSIYFLSWKEQGSQLSLLAKDFESLDCFATEFLIDGSTLSLAVSDEQKNIQVFYYAPKMIESWKGLKLLSRAEFHVGAHVSKFLRLQMVSSGADKINRFALLFGTLDGSFGCIAPLDEVTFRRLQSLQKKLVDAVPHVAGLNPLAFRQFRSSGKARRSGPDSIVDCELLCHYEMLPLEEQLELAHQIGTTRYSILKDLVDLSVGTSFL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
723	Phosphorylation	STCTVSISSPSVLEG CCCEEEECCCHHHCC	28.79	19880383
724	Phosphorylation	TCTVSISSPSVLEGS CCEEEECCCHHHCCC	21.37	19880383
726	Phosphorylation	TVSISSPSVLEGSKR EEEECCCHHHCCCCC	41.08	19880383
901	Phosphorylation	ENPAALNSSGSSKLR CCCCHHCCCCCHHCC	36.61	24243849
902	Phosphorylation	NPAALNSSGSSKLRN CCCHHCCCCCHHCCC	41.44	24243849
1028	Phosphorylation	KATPHQVTYYAEKNL CCCCCEEEEEEHHCC	12.30	19880383
1315	Phosphorylation	FHVGAHVSKFLRLQM EECHHHHHHHHHHHH	14.07	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CPSF1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CPSF1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CPSF1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CPSF2_ARATH	CPSF100	physical	16897494
CPSF_ARATH	CPSF30	physical	16897494

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.