CPSF3_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CPSF3_ARATH
• UniProt AC: Q9C952
• Protein Name: Cleavage and polyadenylation specificity factor subunit 3-I
• Gene Name: CPSF73-I
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 693
• Subcellular Localization: Nucleus .
• Protein Description: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. May function as mRNA 3'-end-processing endonuclease and also be involved in the histone 3'-end pre-mRNA processing..
• Protein Sequence: MASSSTSLKRREQPISRDGDQLIVTPLGAGSEVGRSCVYMSFRGKNILFDCGIHPAYSGMAALPYFDEIDPSSIDVLLITHFHIDHAASLPYFLEKTTFNGRVFMTHATKAIYKLLLTDYVKVSKVSVEDMLFDEQDINKSMDKIEVIDFHQTVEVNGIKFWCYTAGHVLGAAMFMVDIAGVRILYTGDYSREEDRHLRAAELPQFSPDICIIESTSGVQLHQSRHIREKRFTDVIHSTVAQGGRVLIPAFALGRAQELLLILDEYWANHPDLHNIPIYYASPLAKKCMAVYQTYILSMNDRIRNQFANSNPFVFKHISPLNSIDDFNDVGPSVVMATPGGLQSGLSRQLFDSWCSDKKNACIIPGYMVEGTLAKTIINEPKEVTLMNGLTAPLNMQVHYISFSAHADYAQTSTFLKELMPPNIILVHGEANEMMRLKQKLLTEFPDGNTKIMTPKNCESVEMYFNSEKLAKTIGRLAEKTPDVGDTVSGILVKKGFTYQIMAPDELHVFSQLSTATVTQRITIPFVGAFGVIKHRLEKIFESVEFSTDEESGLPALKVHERVTVKQESEKHISLQWSSDPISDMVSDSIVALILNISREVPKIVMEEEDAVKSEEENGKKVEKVIYALLVSLFGDVKLGENGKLVIRVDGNVAQLDKESGEVESEHSGLKERVRVAFERIQSAVKPIPLSAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MASSSTSLKRRE ---CCCCCCCCHHCC	21.37	22074104
6	Phosphorylation	--MASSSTSLKRREQ --CCCCCCCCHHCCC	39.77	25561503
7	Phosphorylation	-MASSSTSLKRREQP -CCCCCCCCHHCCCC	33.56	25561503
120	Phosphorylation	YKLLLTDYVKVSKVS HHHHHCCCCCEECCC	9.27	19880383
589	Phosphorylation	ISDMVSDSIVALILN HHHHHHHHHHHHHHH	16.08	26811356
598	Phosphorylation	VALILNISREVPKIV HHHHHHHCCCCCCEE	22.70	26811356

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CPSF3_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CPSF3_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CPSF3_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CPSF2_ARATH	CPSF100	physical	16897494
CPSF2_ARATH	CPSF100	physical	19748916
CPSF1_ARATH	CPSF160	physical	19748916
FY_ARATH	FY	physical	19748916
CPSF3_ARATH	CPSF73-I	physical	19748916
CLP1_ARATH	CLPS3	physical	19748916

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.