MMP9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MMP9_HUMAN
• UniProt AC: P14780
• Protein Name: Matrix metalloproteinase-9
• Gene Name: MMP9
• Organism: Homo sapiens (Human).
• Sequence Length: 707
• Subcellular Localization: Secreted, extracellular space, extracellular matrix .
• Protein Description: May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide..
• Protein Sequence: MSLWQPLVLVLLVLGCCFAAPRQRQSTLVLFPGDLRTNLTDRQLAEEYLYRYGYTRVAEMRGESKSLGPALLLLQKQLSLPETGELDSATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVVVPTRFGNADGAACHFPFIFEGRSYSACTTDGRSDGLPWCSTTANYDTDDRFGFCPSERLYTQDGNADGKPCQFPFIFQGQSYSACTTDGRSDGYRWCATTANYDRDKLFGFCPTRADSTVMGGNSAGELCVFPFTFLGKEYSTCTSEGRGDGRLWCATTSNFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYGPRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSERPTAGPTGPPSAGPTGPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLFKDGKYWRFSEGRGSRPQGPFLIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLGPRRLDKLGLGADVAQVTGALRSGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVPLDTHDVFQYREKAYFCQDRFYWRVSSRSELNQVDQVGYVTYDILQCPED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLWQPLVL ------CCCHHHHHH	38.01	24043423
26	Phosphorylation	AAPRQRQSTLVLFPG HCHHHCCCEEEECCC	26.37	29083192
27	Phosphorylation	APRQRQSTLVLFPGD CHHHCCCEEEECCCC	16.73	29083192
37	Phosphorylation	LFPGDLRTNLTDRQL ECCCCHHCCCCCHHH	41.71	24719451
38	N-linked_Glycosylation	FPGDLRTNLTDRQLA CCCCHHCCCCCHHHH	34.21	UniProtKB CARBOHYD
48	Phosphorylation	DRQLAEEYLYRYGYT CHHHHHHHHHHHCCC	10.67	24043423
50	Phosphorylation	QLAEEYLYRYGYTRV HHHHHHHHHHCCCCH	10.82	24043423
99	S-nitrosocysteine	KAMRTPRCGVPDLGR HHHCCCCCCCCCCCC	7.30	-
99	S-nitrosylation	KAMRTPRCGVPDLGR HHHCCCCCCCCCCCC	7.30	22178444
120	N-linked_Glycosylation	DLKWHHHNITYWIQN CEEEEECCHHHHHHC	24.76	UniProtKB CARBOHYD
127	N-linked_Glycosylation	NITYWIQNYSEDLPR CHHHHHHCCCCCCCH	32.91	UniProtKB CARBOHYD
241	Phosphorylation	FIFEGRSYSACTTDG EEECCCCEEEECCCC	10.03	-
262	Nitration	WCSTTANYDTDDRFG CCCCCCCCCCCCCCC	20.11	-
576	Phosphorylation	SVFEERLSKKLFFFS HHHHHHHHCCEEEEC	33.68	23909892
583	Phosphorylation	SKKLFFFSGRQVWVY HCCEEEECCCEEEEE	28.10	23909892
628	Phosphorylation	RGKMLLFSGRRLWRF CCEEEEEECCEEEEE	31.21	24719451
686	Phosphorylation	YWRVSSRSELNQVDQ EEEECCHHHHCCCCC	48.67	22210691
696	Phosphorylation	NQVDQVGYVTYDILQ CCCCCCEEEEEEHHC	7.26	22210691
698	Phosphorylation	VDQVGYVTYDILQCP CCCCEEEEEEHHCCC	13.64	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MMP9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MMP9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MMP9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CXCL5_HUMAN	CXCL5	physical	12950257
CXCL6_HUMAN	CXCL6	physical	12950257
TGFB1_HUMAN	TGFB1	physical	10652271
TSP1_HUMAN	THBS1	physical	10900205
TSP2_HUMAN	THBS2	physical	10900205
CLUS_HUMAN	CLU	physical	26716898
COCA1_HUMAN	COL12A1	physical	28514442
TIMP1_HUMAN	TIMP1	physical	28514442
CO2A1_HUMAN	COL2A1	physical	28514442
COEA1_HUMAN	COL14A1	physical	28514442
CO5A1_HUMAN	COL5A1	physical	28514442
CO6A2_HUMAN	COL6A2	physical	28514442
CO4A1_HUMAN	COL4A1	physical	28514442
FINC_HUMAN	FN1	physical	28514442
CO4A2_HUMAN	COL4A2	physical	28514442
CO6A1_HUMAN	COL6A1	physical	28514442
COIA1_HUMAN	COL18A1	physical	28514442
SCAR3_HUMAN	SCARA3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 603932: Intervertebral disc disease (IDD)
• 613073: Metaphyseal anadysplasia 2 (MANDP2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.