MMP26_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MMP26_HUMAN
• UniProt AC: Q9NRE1
• Protein Name: Matrix metalloproteinase-26
• Gene Name: MMP26
• Organism: Homo sapiens (Human).
• Sequence Length: 261
• Subcellular Localization: Secreted, extracellular space, extracellular matrix.
• Protein Description: May hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. Is also able to activate progelatinase B..
• Protein Sequence: MQLVILRVTIFLPWCFAVPVPPAADHKGWDFVEGYFHQFFLTKKESPLLTQETQTQLLQQFHRNGTDLLDMQMHALLHQPHCGVPDGSDTSISPGRCKWNKHTLTYRIINYPHDMKPSAVKDSIYNAVSIWSNVTPLIFQQVQNGDADIKVSFWQWAHEDGWPFDGPGGILGHAFLPNSGNPGVVHFDKNEHWSASDTGYNLFLVATHEIGHSLGLQHSGNQSSIMYPTYWYHDPRTFQLSADDIQRIQHLYGEKCSSDIP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Acetylation	VPPAADHKGWDFVEG CCCCCCCCCHHHHHH	63.34	11566365
35	Phosphorylation	GWDFVEGYFHQFFLT CHHHHHHHHHHHCCC	5.60	-
44	Acetylation	HQFFLTKKESPLLTQ HHHCCCCCCCCCCCH	59.18	11566373
46	Phosphorylation	FFLTKKESPLLTQET HCCCCCCCCCCCHHH	29.72	-
50	Phosphorylation	KKESPLLTQETQTQL CCCCCCCCHHHHHHH	31.85	-
64	N-linked_Glycosylation	LLQQFHRNGTDLLDM HHHHHHHCCCCHHHH	49.50	UniProtKB CARBOHYD
221	N-linked_Glycosylation	LGLQHSGNQSSIMYP CCCCCCCCCCCEECE	41.39	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MMP26_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MMP26_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MMP26_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HEMH_HUMAN	FECH	physical	28514442
MCAT_HUMAN	SLC25A20	physical	28514442
PP1RA_HUMAN	PPP1R10	physical	28514442
EFR3A_HUMAN	EFR3A	physical	28514442
GBB2_HUMAN	GNB2	physical	28514442
PTPRK_HUMAN	PTPRK	physical	28514442
OZF_HUMAN	ZNF146	physical	28514442
DEFM_HUMAN	PDF	physical	28514442
AGRL3_HUMAN	LPHN3	physical	28514442
LAMB2_HUMAN	LAMB2	physical	28514442
EPHA4_HUMAN	EPHA4	physical	28514442
UQCC3_HUMAN	UQCC3	physical	28514442
NDKM_HUMAN	NME4	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.