dbPTM

UQCC3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UQCC3_HUMAN
UniProt AC	Q6UW78
Protein Name	Ubiquinol-cytochrome-c reductase complex assembly factor 3 {ECO:0000312\|HGNC:HGNC:34399}
Gene Name	UQCC3 {ECO:0000312\|HGNC:HGNC:34399}
Organism	Homo sapiens (Human).
Sequence Length	93
Subcellular Localization	Mitochondrion inner membrane Single-pass membrane protein .
Protein Description	Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology..
Protein Sequence	MDSLRKMLISVAMLGAGAGVGYALLVIVTPGERRKQEMLKEMPLQDPRSREEAARTQQLLLATLQEAATTQENVAWRKNWMVGGEGGAGGRSP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
3	Phosphorylation	-----MDSLRKMLIS -----CHHHHHHHHH	26091039
35	Ubiquitination	VTPGERRKQEMLKEM ECCCHHHHHHHHHHC	22817900
40	Ubiquitination	RRKQEMLKEMPLQDP HHHHHHHHHCCCCCC	21890473
56	O-linked_Glycosylation	SREEAARTQQLLLAT HHHHHHHHHHHHHHH	55831859
63	O-linked_Glycosylation	TQQLLLATLQEAATT HHHHHHHHHHHHHHC	51464457
69	O-linked_Glycosylation	ATLQEAATTQENVAW HHHHHHHHCHHHHHH	55831871
70	O-linked_Glycosylation	TLQEAATTQENVAWR HHHHHHHCHHHHHHH	51464463

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of UQCC3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UQCC3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UQCC3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FLOT2_HUMAN	FLOT2	physical	22939629
IMPA3_HUMAN	IMPAD1	physical	22939629
NDUBA_HUMAN	NDUFB10	physical	22939629
SERA_HUMAN	PHGDH	physical	22939629

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UQCC3_HUMAN

Related Literatures of Post-Translational Modification