| UniProt ID | MCM6_ARATH | |
|---|---|---|
| UniProt AC | F4KAB8 | |
| Protein Name | DNA replication licensing factor MCM6 | |
| Gene Name | MCM6 | |
| Organism | Arabidopsis thaliana (Mouse-ear cress). | |
| Sequence Length | 831 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells.. | |
| Protein Sequence | MEAFGGFVMDEQAIQVENVFLEFLKSFRLDANKPELYYEAEIEAIRGGESTMMYIDFSHVMGFNDALQKAIADEYLRFEPYLRNACKRFVIEMNPSFISDDTPNKDINVSFYNLPFTKRLRELTTAEIGKLVSVTGVVTRTSEVRPELLYGTFKCLDCGSVIKNVEQQFKYTQPTICVSPTCLNRARWALLRQESKFADWQRVRMQETSKEIPAGSLPRSLDVILRHEIVEQARAGDTVIFTGTVVVIPDISALAAPGERAECRRDSSQQKSSTAGHEGVQGLKALGVRDLSYRLAFIANSVQIADGSRNTDMRNRQNDSNEDDQQQFTAEELDEIQQMRNTPDYFNKLVGSMAPTVFGHQDIKRAVLLMLLGGVHKTTHEGINLRGDINVCIVGDPSCAKSQFLKYTAGIVPRSVYTSGKSSSAAGLTATVAKEPETGEFCIEAGALMLADNGICCIDEFDKMDIKDQVAIHEAMEQQTISITKAGIQATLNARTSILAAANPVGGRYDKSKPLKYNVNLPPAILSRFDLVYVMIDDPDEVTDYHIAHHIVRVHQKHEAALSPEFTTVQLKRYIAYAKTLKPKLSPEARKLLVESYVALRRGDTTPGTRVAYRMTVRQLEALIRLSEAIARSHLEILVKPSHVLLAVRLLKTSVISVESGDIDLSEYQDANGDNMDDTDDIENPVDGEEDQQNGAAEPASATADNGAAAQKLVISEEEYDRITQALVIRLRQHEETVNKDSSELPGIRQKELIRWFIDQQNEKKKYSSQEQVKLDIKKLRAIIESLVCKEGHLIVLANEQEEAAEAEETKKKSSQRDERILAVAPNYVIE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 407 | Phosphorylation | AKSQFLKYTAGIVPR HHHHHHHHHCCCCCC | 28295753 | ||
| 408 | Phosphorylation | KSQFLKYTAGIVPRS HHHHHHHHCCCCCCC | 28295753 | ||
| 415 | Phosphorylation | TAGIVPRSVYTSGKS HCCCCCCCCCCCCCC | 28295753 | ||
| 417 | Phosphorylation | GIVPRSVYTSGKSSS CCCCCCCCCCCCCCC | 28295753 | ||
| 418 | Phosphorylation | IVPRSVYTSGKSSSA CCCCCCCCCCCCCCC | 28295753 | ||
| 419 | Phosphorylation | VPRSVYTSGKSSSAA CCCCCCCCCCCCCCC | 28295753 | ||
| 527 | Phosphorylation | NLPPAILSRFDLVYV CCCHHHHHCCCEEEE | 24894044 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MCM6_ARATH !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MCM6_ARATH !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MCM6_ARATH !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MCM7_ARATH | PRL | physical | 20706207 | |
| MCM2_ARATH | MCM2 | physical | 20706207 | |
| MCM4_ARATH | MCM4 | physical | 20706207 | |
| PSMD6_ARATH | AT4G24820 | physical | 20706207 | |
| IF2B_ARATH | EIF2 BETA | physical | 20706207 | |
| MTNA_ARATH | AT2G05830 | physical | 20706207 | |
| IMPA1_ARATH | IMPA-1 | physical | 20706207 | |
| MCM5_ARATH | MCM5 | physical | 20706207 | |
| PPR12_ARATH | AT1G05670 | physical | 20706207 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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