MCM2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MCM2_ARATH
• UniProt AC: Q9LPD9
• Protein Name: DNA replication licensing factor MCM2
• Gene Name: MCM2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 936
• Subcellular Localization: Nucleus .
• Protein Description: Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells. May play a crucial role in the control of de-differentiation and cell proliferation processes required for lateral root formation. Is essential for embryo development. Is involved in the geminivirus mungbean yellow mosaic virus (MYMV) DNA replication, presumably in conjunction with other host factors..
• Protein Sequence: MAGENSDNEPSSPASPSSAGFNTDQLPISTSQNSENFSDEEEAAVDTQVIRDEPDEAEDEEEEEGEDLFNDTFMNDYRKMDENDQYESNGIDDSVDDERDLGQAMLDRRAADADLDARENRLANRKLPHLLHDNDSDDWNYRPSKRSRTTVPPRGNGGDPDGNPPSSPGVSQPDISMTDQTDDYQDEDDNDDEAEFEMYRIQGTLREWVMRDEVRRFIAKKFKDFLLTYVKPKNENGDIEYVRLINEMVSANKCSLEIDYKEFIHVHPNIAIWLADAPQPVLEVMEEVSEKVIFDLHPNYKNIHTKIYVRVTNLPVNDQIRNIRQIHLNTMIRIGGVVTRRSGVFPQLQQVKYDCNKCGAVLGPFFQNSYSEVKVGSCSECQSKGPFTVNVEQTIYRNYQKLTIQESPGTVPAGRLPRHKEVILLNDLIDCARPGEEIEVTGIYTNNFDLSLNTKNGFPVFATVVEANYVTKKQDLFSAYKLTQEDKTQIEELSKDPRIVERIIKSIAPSIYGHEDIKTALALAMFGGQEKNIKGKHRLRGDINVLLLGDPGTAKSQFLKYVEKTGQRAVYTTGKGASAVGLTAAVHKDPVTREWTLEGGALVLADRGICLIDEFDKMNDQDRVSIHEAMEQQSISISKAGIVTSLQARCSVIAAANPVGGRYDSSKSFAQNVELTDPILSRFDILCVVKDVVDPVTDEMLAEFVVNSHFKSQPKGGKMEDSDPEDGIQGSSGSTDPEVLPQNLLKKYLTYSKLYVFPKLGELDAKKLETVYANLRRESMNGQGVSIATRHLESMIRMSEAHARMHLRQYVTEEDVNMAIRVLLDSFISTQKFGVQRTLRESFKRYITYKKDFNSLLLVLLKELVKNALKFEEIISGSNSGLPTIEVKIEELQTKAKEYDIADLRPFFSSTDFSKAHFELDHGRGMIKCPKRLITW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
483	Phosphorylation	LFSAYKLTQEDKTQI HHHHHCCCHHHHHHH		23776212
488	Phosphorylation	KLTQEDKTQIEELSK CCCHHHHHHHHHHHC		23776212
506	Phosphorylation	IVERIIKSIAPSIYG HHHHHHHHHHHHHCC		19880383
512	Phosphorylation	KSIAPSIYGHEDIKT HHHHHHHCCCHHHHH		19880383
553	Phosphorylation	LLLGDPGTAKSQFLK EEECCCCCHHHHHHH		19880383
722	Phosphorylation	KGGKMEDSDPEDGIQ CCCCCCCCCCCCCCC		23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MCM2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MCM2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MCM2_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of MCM2_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.