MCM7_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MCM7_ARATH
• UniProt AC: P43299
• Protein Name: DNA replication licensing factor MCM7
• Gene Name: MCM7
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 716
• Subcellular Localization: Nucleus . Cytoplasm . Localized in the nucleus during G1, S and G2 phases of the cell cycle, and released into the cytoplasmic compartment during mitosis.
• Protein Description: Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells (By similarity). Required for megagametophyte and embryo development..
• Protein Sequence: MKDHDFDGDKGLAKGFLENFADANGRSKYMEILQEVSNRKIRAIQVDLDDLFNYKDESEEFLGRLTENTRRYVSIFSAAVDELLPEPTEAFPDDDHDILMTQRADDGTDNPDVSDPHQQIPSEIKRYYEVYFKAPSKGRPSTIREVKASHIGQLVRISGIVTRCSDVKPLMAVAVYTCEDCGHEIYQEVTSRVFMPLFKCPSSRCRLNSKAGNPILQLRASKFLKFQEAKMQELAEHVPKGHIPRSMTVHLRGELTRKVSPGDVVEFSGIFLPIPYTGFKALRAGLVADTYLEATSVTHFKKKYEEYEFQKDEEEQIARLAEDGDIYNKLSRSLAPEIYGHEDIKKALLLLLVGAPHRQLKDGMKIRGDVHICLMGDPGVAKSQLLKHIINVAPRGVYTTGKGSSGVGLTAAVMRDQVTNEMVLEGGALVLADMGICAIDEFDKMDESDRTAIHEVMEQQTVSIAKAGITTSLNARTAVLAAANPAWGRYDLRRTPAENINLPPALLSRFDLLWLILDRADMDSDLELAKHVLHVHQTEESPALGFEPLEPNILRAYISAARRLSPYVPAELEEYIATAYSSIRQEEAKSNTPHSYTTVRTLLSILRISAALARLRFSESVAQSDVDEALRLMQMSKISLYADDRQKAGLDAISDTYSIIRDEAARSKKTHVSYANALNWISRKGYSEAQLKECLEEYAALNVWQIDPHTFDIRFI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
108	Phosphorylation	TQRADDGTDNPDVSD EEECCCCCCCCCCCC		30291188
158	Phosphorylation	IGQLVRISGIVTRCS HHHHEEEEEEEEECC		28011693
601	Phosphorylation	HSYTTVRTLLSILRI CCHHHHHHHHHHHHH		19880383
604	Phosphorylation	TTVRTLLSILRISAA HHHHHHHHHHHHHHH		19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MCM7_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MCM7_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MCM7_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GUN9_ARATH	CEL3	physical	20706207

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.