MCM4_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MCM4_ARATH
• UniProt AC: Q0WVF5
• Protein Name: DNA replication licensing factor MCM4
• Gene Name: MCM4
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 847
• Subcellular Localization: Nucleus .
• Protein Description: Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells..
• Protein Sequence: MASDSSLGNTNDGPPSPGENVSSPIENTYSSPAALHRRRRGRSSTPTQFATPPPPPSRLASSNSTPPTSRPSAARSKGRNGHGGGGGGGGGGDPGTPMSTDEPLPSSDDGEEDGGDDTTPTFVWGTNISVQDVKSAIEMFVKHFREARENSDDLFREGKYMVSIRKVIEIEGEWIDVDAFDVFDYDPDLYNKMVRYPLEVLAIFDIVLMDIVSTINRLFEKHVQVRIFNLRTSTSMRNLNPSDIEKMISLKGMIIRSSSIIPEIREAVFRCLVCGYFSDPIIVDRGKISEPPTCLKQECMTKNSMTLVHNRCRFADKQIVRLQETPDEIPEGGTPHTVSLLLHDKLVDNGKPGDRIEVTGIYRAMTVRVGPAHRTVKSVFKTYIDCLHIKKASKLRMSAEDPMDVDNSLRRVDEDVELDEEKLRKFQELSKQPDIYERLSRSLAPNIWELDDVKKGLLCQLFGGNALNLASGANFRGDINILLVGDPGTSKSQLLQYIHKLSPRGIYTSGRGSSAVGLTAYVAKDPETGETVLESGALVLSDRGICCIDEFDKMSDSARSMLHEVMEQQTVSIAKAGIIASLNARTSVLACANPSGSRYNPRLSVIENIHLPPTLLSRFDLIYLILDKPDEQTDRRLAKHIVALHFENAESAQEEAIDITTLTTYVSYARKNIHPKLSDEAAEELTRGYVELRKAGKFAGSSKKVITATPRQIESLIRLSEALARMRFSEWVEKHDVDEAFRLLRVAMQQSATDHATGTIDMDLINTGVSASERMRRDTFASSIRDIALEKMQIGGSSMRLSELLEELKKHGGNINTEIHLHDVRKAVATLASEGFLVAEGDRIKRV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MASDSSLGNTNDG --CCCCCCCCCCCCC		27531888
10	Phosphorylation	SDSSLGNTNDGPPSP CCCCCCCCCCCCCCC		27531888
16	Phosphorylation	NTNDGPPSPGENVSS CCCCCCCCCCCCCCC		27531888
22	Phosphorylation	PSPGENVSSPIENTY CCCCCCCCCCCCCCC		30589143
23	Phosphorylation	SPGENVSSPIENTYS CCCCCCCCCCCCCCC		30589143
43	Phosphorylation	HRRRRGRSSTPTQFA HHHHCCCCCCCCCCC		29654922
44	Phosphorylation	RRRRGRSSTPTQFAT HHHCCCCCCCCCCCC		25561503
45	Phosphorylation	RRRGRSSTPTQFATP HHCCCCCCCCCCCCC		25561503
47	Phosphorylation	RGRSSTPTQFATPPP CCCCCCCCCCCCCCC		25561503
51	Phosphorylation	STPTQFATPPPPPSR CCCCCCCCCCCCCHH		25561503
61	Phosphorylation	PPPSRLASSNSTPPT CCCHHCCCCCCCCCC		19880383
62	Phosphorylation	PPSRLASSNSTPPTS CCHHCCCCCCCCCCC		30407730
64	Phosphorylation	SRLASSNSTPPTSRP HHCCCCCCCCCCCCC		30407730
65	Phosphorylation	RLASSNSTPPTSRPS HCCCCCCCCCCCCCH		30407730
68	Phosphorylation	SSNSTPPTSRPSAAR CCCCCCCCCCCHHHH		30407730
69	Phosphorylation	SNSTPPTSRPSAARS CCCCCCCCCCHHHHC		30407730
72	Phosphorylation	TPPTSRPSAARSKGR CCCCCCCHHHHCCCC		30407730
151	Phosphorylation	FREARENSDDLFREG HHHHHHCCCHHHHCC		25561503
442	Phosphorylation	IYERLSRSLAPNIWE HHHHHHHHHCCCCCC		24243849
604	Phosphorylation	SRYNPRLSVIENIHL CCCCCCCCCEECCCC		25368622
614	Phosphorylation	ENIHLPPTLLSRFDL ECCCCCHHHHHCCCE		25368622
617	Phosphorylation	HLPPTLLSRFDLIYL CCCHHHHHCCCEEEH		25368622
623	Phosphorylation	LSRFDLIYLILDKPD HHCCCEEEHHCCCCC		25368622
633	Phosphorylation	LDKPDEQTDRRLAKH CCCCCHHHHHHHHHH		25368622

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MCM4_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MCM4_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MCM4_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of MCM4_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.