IMPA1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IMPA1_ARATH
• UniProt AC: Q96321
• Protein Name: Importin subunit alpha-1 {ECO:0000305}
• Gene Name: IMPA1 {ECO:0000303|PubMed:18836040}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 532
• Subcellular Localization: Nucleus envelope .
• Protein Description: Binds to conventional NLS motifs with high affinity in the absence of an importin beta subunit. Mediates nuclear protein import across the nuclear envelope in vitro in the absence of exogenously added importin beta subunit. [PubMed: 10428841 Acts as cellular receptor for the nuclear import of the virD2 protein of Agrobacterium, but is not essential for Agrobacterium-mediated root transformation]
• Protein Sequence: MSLRPNAKTEVRRNRYKVAVDAEEGRRRREDNMVEIRKSKREESLMKKRREGMQALQGFPSASAASVDKKLDSLKDMVAGVWSDDPALQLESTTQFRKLLSIERSPPIEEVISAGVVPRFVEFLKKEDYPAIQFEAAWALTNIASGTSDHTKVVIDHNAVPIFVQLLASPSDDVREQAVWALGNVAGDSPRCRDLVLGCGALLPLLNQLNEHAKLSMLRNATWTLSNFCRGKPQPHFDQVKPALPALERLIHSDDEEVLTDACWALSYLSDGTNDKIQTVIQAGVVPKLVELLLHHSPSVLIPALRTVGNIVTGDDIQTQCVINSGALPCLANLLTQNHKKSIKKEACWTISNITAGNKDQIQTVVEANLISPLVSLLQNAEFDIKKEAAWAISNATSGGSHDQIKYLVEQGCIKPLCDLLVCPDPRIITVCLEGLENILKVGEAEKNLGHTGDMNYYAQLIDDAEGLEKIENLQSHDNNEIYEKAVKILETYWLEEEDDETQQPPGVDGSQAGFQFGGNQAPVPSGGFNFS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Sulfoxidation	SKREESLMKKRREGM HHHHHHHHHHHHHHH		25693801
101	Phosphorylation	TQFRKLLSIERSPPI HHHHHHHCCCCCCCH		26811356
189	Phosphorylation	LGNVAGDSPRCRDLV HHHHCCCCHHHHHHH		23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IMPA1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IMPA1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IMPA1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MCES1_ARATH	AT3G20650	physical	21976714
LHP1_ARATH	TFL2	physical	21798944
IAA19_ARATH	IAA19	physical	21798944
SINL7_ARATH	AT5G37890	physical	21798944
PAP1_ARATH	FIB	physical	21798944
CDC23_ARATH	APC8	physical	21798944
NIMI2_ARATH	NIMIN-2	physical	21798944

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.