dbPTM

MCES1_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MCES1_ARATH
UniProt AC	Q9LHQ7
Protein Name	mRNA cap guanine-N7 methyltransferase 1
Gene Name	At3g20650
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	370
Subcellular Localization	Nucleus.
Protein Description	mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC (By similarity)..
Protein Sequence	MKRGFSDSPSSSAPPPSSRFKSNPEGDSQFLEDETTKNFARKVADHYSRRTNQTLEEREASPIIHLKKLNNWIKSVLIQLYARPDDAVLDLACGKGGDLIKWDKARIGYYVGIDIAEGSIEDCRTRYNGDADHHQRRKKFSFPSRLLCGDCFEVELDKILEEDAPFDICSCQFAMHYSWTTEARARRALANVSALLRPGGVFIGTMPDANVIIKKLREAEGLEIGNSVYWIRFGEEYSQKKFKSSSPFGIEYVFHLEDAVDCPEWIVPFNVFKSLAEEYDLELVFVKNSHEFVHEYMKKPEFVELMRRLGALGDGSNDQSTLSADEWEAAYLYLSFVLRKRGESDGARRSGRRKNGKMNLSKDDVLYIDS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MKRGFSDSPSSSA --CCCCCCCCCCCCC	39.75	30407730
8	Phosphorylation	MKRGFSDSPSSSAPP CCCCCCCCCCCCCCC	26.03	25561503
10	Phosphorylation	RGFSDSPSSSAPPPS CCCCCCCCCCCCCCH	40.66	30407730
11	Phosphorylation	GFSDSPSSSAPPPSS CCCCCCCCCCCCCHH	33.62	30407730
12	Phosphorylation	FSDSPSSSAPPPSSR CCCCCCCCCCCCHHH	49.48	30407730

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MCES1_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MCES1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MCES1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
SAHH1_ARATH	MEE58	physical	21976714
ADK1_ARATH	ADK1	physical	21976714

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MCES1_ARATH

Related Literatures of Post-Translational Modification