| UniProt ID | CDC23_ARATH | |
|---|---|---|
| UniProt AC | Q9STS3 | |
| Protein Name | Anaphase-promoting complex subunit 8 | |
| Gene Name | APC8 | |
| Organism | Arabidopsis thaliana (Mouse-ear cress). | |
| Sequence Length | 579 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex controls several key steps in the cell cycle by mediating ubiquitination and subsequent degradation of target proteins such as cyclins. The APC/C complex is required for the female gametophyte development and is involved in several aspect of development by controlling cell division and cell elongation. Involved in the control of endoreduplication.. | |
| Protein Sequence | MVSKECCRNEIRAAIRQLSDRCLYSAAKWAGEQLVGIEQDPSNFTPANTRFQRGSSSIRRRFSTNESISTPLPSVGFSQAATPLPEEDEAIDGDIYLLAKSYFDCREYRRASHMLRDQVSKKSLFLRYYALYLAGEKRKEEEMIELEGPLGKSDAINRELVSLERDLSALRRTGAIDSFGLYLYGVVLKEKGNESLARASLVESVNSYPWNWSAWSELQSLCTSIEILNSLNLNNHWMKEFFLGNAYQELRMHTESLAKYEYLQGIFSFSNYIQAQTAKAQYSLREFDQVEIMFEELLRNDPYRVEDMDLYSNVLYAKEACAALSYLAHKVFLTDKYRPESCCIIGNYYSLKGQHEKAVMYFRRALKLNKKYLSAWTLMGHEYVEMKNTPAAIDAYRRAVDINPTDYRAWYGLGQAYEMMGMPFYALHYFRKSIFFLPNDSRLWIAMAKCYQTEQLYMLEEAIKCYKRAVNCTDTEGIALNQLAKLHQKLGRNEEAAYYFEKDLERMDAEGLEGPNMFEALVFLATHFKNHKKFEEAEVYCTRLLDYSGPEKEKAKSLLRGIRMAQTGFPSMDLEHFPI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 112 | Phosphorylation | CREYRRASHMLRDQV HHHHHHHHHHHHHHH | 13.97 | 24894044 | |
| 120 | Phosphorylation | HMLRDQVSKKSLFLR HHHHHHHCHHHHHHH | 28.82 | 24894044 | |
| 547 | Phosphorylation | YCTRLLDYSGPEKEK HHHHHHCCCCCCHHH | 18.59 | 25561503 | |
| 548 | Phosphorylation | CTRLLDYSGPEKEKA HHHHHCCCCCCHHHH | 47.76 | 25561503 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CDC23_ARATH !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CDC23_ARATH !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CDC23_ARATH !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| APC2_ARATH | APC2 | physical | 14508008 | |
| APC5_ARATH | AT1G06590 | physical | 20706207 | |
| CDC16_ARATH | APC6 | physical | 20706207 | |
| PYM_ARATH | UVI4 | physical | 20706207 | |
| APC1_ARATH | EMB2771 | physical | 20706207 | |
| APC4_ARATH | AT4G21530 | physical | 20706207 | |
| PSMD6_ARATH | AT4G24820 | physical | 20706207 | |
| MTNA_ARATH | AT2G05830 | physical | 20706207 | |
| ASE2_ARATH | ASE2 | physical | 21798944 | |
| PSAD1_ARATH | PSAD-1 | physical | 21798944 | |
| KAN1_ARATH | KAN | physical | 21798944 | |
| VAR3_ARATH | VAR3 | physical | 21798944 | |
| RS101_ARATH | AT4G25740 | physical | 21798944 | |
| P2C80_ARATH | AT5G66720 | physical | 21798944 | |
| PUB14_ARATH | PUB14 | physical | 21798944 | |
| NDS5B_ARATH | AT3G62790 | physical | 21798944 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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