MCM5_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MCM5_ARATH
• UniProt AC: O80786
• Protein Name: DNA replication licensing factor MCM5
• Gene Name: MCM5
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 727
• Subcellular Localization: Nucleus. Cytoplasm. Localized in the nucleus during G1, S and G2 phases of the cell cycle, and released into the cytoplasmic compartment during mitosis.
• Protein Description: Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells..
• Protein Sequence: MSGWDEGAVYYSDQPQFPEAGDAATISPHAVLTKFKEFIRNFEIEQNCFPYREALLDNPKRLVVHLEDLLSFDSDLPSLIRSAPADYLPVFEKAAGEVLTGLKMREANEGGVMEEPLTRDVQILLTSREDPVSMRLLGAQYISKLVKISGISIAASRVKAKATYVFLVCKNCKKTREVPCRPGLGGAIVPRSCDNIPQPGEEPCPLDPWMVVPDRSQYVDQQTLKLQENPEDVPTGELPRNMLLSVDRHLVQTIVPGTRLTVMGIYSIFQASSSSNSHKGAVAIRQPYIRVVGLEDTNEASSRGPANFTPDEEEEFKKFADSQDVYKNICTKIAPSIFGHEDVKRAAACLLFGGSRKSLPDGVKLRGDINVLLLGDPSTAKSQFLKFVEKTAPIAVYTSGKGSSAAGLTASVIRDSSTREFYLEGGAMVLADGGVVCIDEFDKMRPEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPPSGRYDDLKTAQDNIDLQTTILSRFDLIFIVKDIRKYSQDKEIASHIIRVHASANKFSDENTDSKEDNWLKRYIQYCRARCHPRLSKDAAENLQRKYVTIRMDMKRRAHETGEAAPIPITVRQLEAIVRLSESLAKMRLSHEATPDDVDKAFKLFDTSTMDAARSGINQQINITGEMANEIKQAETQIKRRMGIGARLSERRLIEDLARMGMNDSMVRRALLIMHQRGEVEYQRERRSIVRKA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
542	Phosphorylation	HASANKFSDENTDSK HHHCCCCCCCCCCCC		28295753
546	Phosphorylation	NKFSDENTDSKEDNW CCCCCCCCCCCCCHH		28295753
548	Phosphorylation	FSDENTDSKEDNWLK CCCCCCCCCCCHHHH		28295753
615	Phosphorylation	LEAIVRLSESLAKMR HHHHHHHHHHHHHCC		23776212
617	Phosphorylation	AIVRLSESLAKMRLS HHHHHHHHHHHCCCC		23776212
670	Phosphorylation	NEIKQAETQIKRRMG HHHHHHHHHHHHHHC		24894044

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MCM5_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MCM5_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MCM5_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of MCM5_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.