MB3L1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MB3L1_HUMAN
• UniProt AC: Q8WWY6
• Protein Name: Methyl-CpG-binding domain protein 3-like 1
• Gene Name: MBD3L1
• Organism: Homo sapiens (Human).
• Sequence Length: 194
• Subcellular Localization: Nucleus . Nuclear, in large foci.
• Protein Description: Transcriptional repressor..
• Protein Sequence: MAKSSQRKQRDCVNQCKSKPGLSTSIPLRMSSYTFKRPVTRITPHPGNEVRYHQWEESLEKPQQVCWQRRLQGLQAYSSAGELSSTLDLANTLQKLVPSYTGGSLLEDLASGLEHSCPMPHLACSSDAVEIIPAEGVGISQLLCKQFLVTEEDIRKQEGKVKTVRERLAIALIADGLANEAEKVRDQEGRPEKR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	CKSKPGLSTSIPLRM HHCCCCCCCCCCEEC	26.48	26657352
25	Phosphorylation	SKPGLSTSIPLRMSS CCCCCCCCCCEECCE	20.87	26657352
77	Phosphorylation	RLQGLQAYSSAGELS HHHHHHHHHCCCHHH	7.09	21214269
78	Phosphorylation	LQGLQAYSSAGELSS HHHHHHHHCCCHHHH	19.41	21214269
92	Phosphorylation	STLDLANTLQKLVPS HHHHHHHHHHHHCCC	25.59	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MB3L1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MB3L1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MB3L1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MBD3_HUMAN	MBD3	physical	15456747
MBD2_HUMAN	MBD2	physical	15456747
HDAC1_HUMAN	HDAC1	physical	15456747
HDAC2_HUMAN	HDAC2	physical	15456747
RBBP7_HUMAN	RBBP7	physical	15456747
RBBP4_HUMAN	RBBP4	physical	15456747
MTA1_HUMAN	MTA1	physical	15456747
MTA2_HUMAN	MTA2	physical	15456747
SIN3A_HUMAN	SIN3A	physical	15456747
CHD3_HUMAN	CHD3	physical	15456747
RBBP4_HUMAN	RBBP4	physical	26186194
RBBP7_HUMAN	RBBP7	physical	26186194
HDAC1_HUMAN	HDAC1	physical	26186194
HDAC2_HUMAN	HDAC2	physical	26186194
P66B_HUMAN	GATAD2B	physical	26186194
P66A_HUMAN	GATAD2A	physical	26186194
CHD3_HUMAN	CHD3	physical	26186194
CHD4_HUMAN	CHD4	physical	26186194
ZN521_HUMAN	ZNF521	physical	26186194
ZN423_HUMAN	ZNF423	physical	26186194
MTA2_HUMAN	MTA2	physical	26186194
MTA1_HUMAN	MTA1	physical	26186194
MTA3_HUMAN	MTA3	physical	26186194
CDKA1_HUMAN	CDK2AP1	physical	26186194
BEND7_HUMAN	BEND7	physical	26186194
BC11A_HUMAN	BCL11A	physical	26186194
ZN296_HUMAN	ZNF296	physical	26186194
GBB4_HUMAN	GNB4	physical	26186194
ZBTB2_HUMAN	ZBTB2	physical	26186194
ZN219_HUMAN	ZNF219	physical	26186194
ZN219_HUMAN	ZNF219	physical	28514442
MTA3_HUMAN	MTA3	physical	28514442
P66B_HUMAN	GATAD2B	physical	28514442
P66A_HUMAN	GATAD2A	physical	28514442
ZN296_HUMAN	ZNF296	physical	28514442
BC11A_HUMAN	BCL11A	physical	28514442
BEND7_HUMAN	BEND7	physical	28514442
MTA1_HUMAN	MTA1	physical	28514442
CHD4_HUMAN	CHD4	physical	28514442
CDKA1_HUMAN	CDK2AP1	physical	28514442
ZN521_HUMAN	ZNF521	physical	28514442
MTA2_HUMAN	MTA2	physical	28514442
CHD3_HUMAN	CHD3	physical	28514442
ZN423_HUMAN	ZNF423	physical	28514442
ZBTB2_HUMAN	ZBTB2	physical	28514442
HDAC1_HUMAN	HDAC1	physical	28514442
RBBP7_HUMAN	RBBP7	physical	28514442
HDAC2_HUMAN	HDAC2	physical	28514442
RBBP4_HUMAN	RBBP4	physical	28514442
GT2D1_HUMAN	GTF2IRD1	physical	26275350

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.