LITD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LITD1_HUMAN
• UniProt AC: Q5T7N2
• Protein Name: LINE-1 type transposase domain-containing protein 1
• Gene Name: L1TD1
• Organism: Homo sapiens (Human).
• Sequence Length: 865
• Protein Sequence: MSDVSTSVQSKFARLAKKKENITYMKREQLTETDKDIAPVLDLKCKDVSAIMNKFKVLMEIQDLMFEEMRETLKNDLKAVLGGKATIPEVKNSENSSSRTEFQQIINLALQKTGMVGKIEGENSKIGDDNENLTFKLEVNELSGKLDNTNEYNSNDGKKLPQGESRSYEVMGSMEETLCNIDDRDGNRNVHLEFTERESRKDGEDEFVKEMREERKFQKLKNKEEVLKASREEKVLMDEGAVLTLVADLSSATLDISKQWSNVFNILRENDFEPKFLCEVKLAFKCDGEIKTFSDLQSLRKFASQKSSVKELLKDVLPQKEEINQGGRKYGIQEKRDKTLIDSKHRAGEITSDGLSFLFLKEVKVAKPEEMKNLETQEEEFSELEELDEEASGMEDDEDTSGLEEEEEEPSGLEEEEEEEASGLEEDEASGLEEEEEQTSEQDSTFQGHTLVDAKHEVEITSDGMETTFIDSVEDSESEEEEEGKSSETGKVKTTSLTEKKASRRQKEIPFSYLVGDSGKKKLVKHQVVHKTQEEEETAVPTSQGTGTPCLTLCLASPSKSLEMSHDEHKKHSHTNLSISTGVTKLKKTEEKKHRTLHTEELTSKEADLTEETEENLRSSVINSIREIKEEIGNLKSSHSGVLEIENSVDDLSSRMDILEERIDSLEDQIEEFSKDTMQMTKQIISKERQRDIEERSRSCNIRLIGIPEKESYENRAEDIIKEIIDENFAELKKGSSLEIVSACRVPSKIDEKRLTPRHILVKFWNSSDKEKIIRASRERREITYQGTRIRLTADLSLDTLDARSKWSNVFKVLLEKGFNPRILYPAKMAFDFRGKTKVFLSIEEFRDYVLHMPTLRELLGNNIP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSDVSTSVQ ------CCCHHHHHH	46.87	21406692
2	Phosphorylation	------MSDVSTSVQ ------CCCHHHHHH	46.87	21406692
5	Phosphorylation	---MSDVSTSVQSKF ---CCCHHHHHHHHH	21.69	23532336
18	Ubiquitination	KFARLAKKKENITYM HHHHHHHHHHCCCEE	60.76	-
24	Phosphorylation	KKKENITYMKREQLT HHHHCCCEEEHHHCC	9.24	-
26	Ubiquitination	KENITYMKREQLTET HHCCCEEEHHHCCCC	42.23	-
44	Ubiquitination	IAPVLDLKCKDVSAI CHHHHCCCCCCHHHH	38.62	-
46	Ubiquitination	PVLDLKCKDVSAIMN HHHCCCCCCHHHHHH	60.62	-
49	Phosphorylation	DLKCKDVSAIMNKFK CCCCCCHHHHHHHHH	23.39	21406692
54	Ubiquitination	DVSAIMNKFKVLMEI CHHHHHHHHHHHHHH	29.22	-
78	Ubiquitination	ETLKNDLKAVLGGKA HHHHHHHHHHHCCCC	39.03	-
84	Ubiquitination	LKAVLGGKATIPEVK HHHHHCCCCCCCCCC	40.33	-
91	Ubiquitination	KATIPEVKNSENSSS CCCCCCCCCCCCCCC	53.76	-
93	Phosphorylation	TIPEVKNSENSSSRT CCCCCCCCCCCCCHH	32.22	27174698
96	Phosphorylation	EVKNSENSSSRTEFQ CCCCCCCCCCHHHHH	26.16	27174698
97	Phosphorylation	VKNSENSSSRTEFQQ CCCCCCCCCHHHHHH	35.11	21406692
98	Phosphorylation	KNSENSSSRTEFQQI CCCCCCCCHHHHHHH	42.94	21406692
100	Phosphorylation	SENSSSRTEFQQIIN CCCCCCHHHHHHHHH	43.00	21406692
112	Ubiquitination	IINLALQKTGMVGKI HHHHHHHHHCCCCEE	48.15	-
113	Phosphorylation	INLALQKTGMVGKIE HHHHHHHHCCCCEEE	19.97	-
118	Ubiquitination	QKTGMVGKIEGENSK HHHCCCCEEECCCCC	26.61	-
124	Phosphorylation	GKIEGENSKIGDDNE CEEECCCCCCCCCCC	22.73	-
125	Ubiquitination	KIEGENSKIGDDNEN EEECCCCCCCCCCCC	63.39	-
136	Ubiquitination	DNENLTFKLEVNELS CCCCEEEEEEHHHCC	38.20	-
143	Phosphorylation	KLEVNELSGKLDNTN EEEHHHCCCCCCCCC	27.92	21406692
145	Ubiquitination	EVNELSGKLDNTNEY EHHHCCCCCCCCCCC	49.65	-
149	Phosphorylation	LSGKLDNTNEYNSND CCCCCCCCCCCCCCC	29.15	21406692
152	Phosphorylation	KLDNTNEYNSNDGKK CCCCCCCCCCCCCCC	26.43	21406692
154	Phosphorylation	DNTNEYNSNDGKKLP CCCCCCCCCCCCCCC	35.08	21406692
158	Ubiquitination	EYNSNDGKKLPQGES CCCCCCCCCCCCCCC	54.74	-
159	Ubiquitination	YNSNDGKKLPQGESR CCCCCCCCCCCCCCC	71.57	-
173	Phosphorylation	RSYEVMGSMEETLCN CCEEEECCHHEEECC	12.62	-
209	Ubiquitination	DGEDEFVKEMREERK CCCCHHHHHHHHHHH	51.63	-
212	Dimethylation	DEFVKEMREERKFQK CHHHHHHHHHHHHHH	43.65	-
212	Methylation	DEFVKEMREERKFQK CHHHHHHHHHHHHHH	43.65	24377387
221	Ubiquitination	ERKFQKLKNKEEVLK HHHHHHHCCHHHHHH	73.36	-
258	Ubiquitination	SATLDISKQWSNVFN HCCCCHHHHHHHHHH	57.00	-
281	Ubiquitination	PKFLCEVKLAFKCDG CCEEEEEEEEEECCC	16.29	-
291	Ubiquitination	FKCDGEIKTFSDLQS EECCCEEEEHHHHHH	38.93	-
292	Phosphorylation	KCDGEIKTFSDLQSL ECCCEEEEHHHHHHH	33.75	21406692
294	Phosphorylation	DGEIKTFSDLQSLRK CCEEEEHHHHHHHHH	42.51	21406692
298	Phosphorylation	KTFSDLQSLRKFASQ EEHHHHHHHHHHHHC	37.12	21406692
306	Ubiquitination	LRKFASQKSSVKELL HHHHHHCCHHHHHHH	42.05	-
320	Ubiquitination	LKDVLPQKEEINQGG HHHHCCCHHHHCCCC	56.21	-
351	Phosphorylation	KHRAGEITSDGLSFL CCCCCCCCCCCCCEE	19.23	21406692
352	Phosphorylation	HRAGEITSDGLSFLF CCCCCCCCCCCCEEE	35.03	21406692
356	Phosphorylation	EITSDGLSFLFLKEV CCCCCCCCEEEEEEC	25.98	-
361	Ubiquitination	GLSFLFLKEVKVAKP CCCEEEEEECEECCH	53.80	-
364	Ubiquitination	FLFLKEVKVAKPEEM EEEEEECEECCHHHH	37.25	-
440	Phosphorylation	EEEEEQTSEQDSTFQ HHHHHHCCCCCCCCC	32.71	-
450	Phosphorylation	DSTFQGHTLVDAKHE CCCCCCCEEEECCEE	34.99	-
461	Phosphorylation	AKHEVEITSDGMETT CCEEEEECCCCCEEE	13.78	21406692
462	Phosphorylation	KHEVEITSDGMETTF CEEEEECCCCCEEEE	37.52	21406692
467	Phosphorylation	ITSDGMETTFIDSVE ECCCCCEEEEEEECC	20.36	21406692
468	Phosphorylation	TSDGMETTFIDSVED CCCCCEEEEEEECCC	12.80	21406692
472	Phosphorylation	METTFIDSVEDSESE CEEEEEEECCCCCCH	23.69	21406692
476	Phosphorylation	FIDSVEDSESEEEEE EEEECCCCCCHHHHC	29.53	21406692
478	Phosphorylation	DSVEDSESEEEEEGK EECCCCCCHHHHCCC	55.02	21406692
486	Phosphorylation	EEEEEGKSSETGKVK HHHHCCCCCCCCCCC	44.24	21406692
487	Phosphorylation	EEEEGKSSETGKVKT HHHCCCCCCCCCCCC	42.54	21406692
489	Phosphorylation	EEGKSSETGKVKTTS HCCCCCCCCCCCCCC	44.22	21406692
494	Phosphorylation	SETGKVKTTSLTEKK CCCCCCCCCCCCHHH	25.30	30622161
495	Phosphorylation	ETGKVKTTSLTEKKA CCCCCCCCCCCHHHH	18.93	30622161
496	Phosphorylation	TGKVKTTSLTEKKAS CCCCCCCCCCHHHHH	38.23	30622161
498	Phosphorylation	KVKTTSLTEKKASRR CCCCCCCCHHHHHHC	45.59	30622161
513	Phosphorylation	QKEIPFSYLVGDSGK CCCCCHHHCCCCCCC	13.04	-
518	Phosphorylation	FSYLVGDSGKKKLVK HHHCCCCCCCEEEEE	46.73	19664995
532	Phosphorylation	KHQVVHKTQEEEETA EEEEEECCHHHHHCC	26.74	21406692
538	Phosphorylation	KTQEEEETAVPTSQG CCHHHHHCCCCCCCC	35.91	21406692
542	Phosphorylation	EEETAVPTSQGTGTP HHHCCCCCCCCCCCC	27.38	21406692
543	Phosphorylation	EETAVPTSQGTGTPC HHCCCCCCCCCCCCE	22.12	21406692
546	Phosphorylation	AVPTSQGTGTPCLTL CCCCCCCCCCCEEEE	30.19	19664995
548	Phosphorylation	PTSQGTGTPCLTLCL CCCCCCCCCEEEEEE	15.63	19664995
552	Phosphorylation	GTGTPCLTLCLASPS CCCCCEEEEEEECCC	23.34	19664995
557	Phosphorylation	CLTLCLASPSKSLEM EEEEEEECCCCCCCC	19.43	19664995
559	Phosphorylation	TLCLASPSKSLEMSH EEEEECCCCCCCCCC	32.17	29888752
561	Phosphorylation	CLASPSKSLEMSHDE EEECCCCCCCCCCCC	33.62	21406692
565	Phosphorylation	PSKSLEMSHDEHKKH CCCCCCCCCCCHHHC	20.57	21406692
573	Phosphorylation	HDEHKKHSHTNLSIS CCCHHHCCCCCCEEH	40.67	21406692
575	Phosphorylation	EHKKHSHTNLSISTG CHHHCCCCCCEEHHC	40.65	21406692
578	Phosphorylation	KHSHTNLSISTGVTK HCCCCCCEEHHCCCC	19.30	21406692
580	Phosphorylation	SHTNLSISTGVTKLK CCCCCEEHHCCCCCC	18.74	21406692
581	Phosphorylation	HTNLSISTGVTKLKK CCCCEEHHCCCCCCC	33.72	21406692
584	Phosphorylation	LSISTGVTKLKKTEE CEEHHCCCCCCCCHH	31.81	21406692
585	Ubiquitination	SISTGVTKLKKTEEK EEHHCCCCCCCCHHH	56.77	-
596	Phosphorylation	TEEKKHRTLHTEELT CHHHHHHCCCHHHHH	23.70	21406692
599	Phosphorylation	KKHRTLHTEELTSKE HHHHCCCHHHHHHCC	33.98	21406692
603	Phosphorylation	TLHTEELTSKEADLT CCCHHHHHHCCCCCC	40.82	21406692
604	Phosphorylation	LHTEELTSKEADLTE CCHHHHHHCCCCCCH	40.92	21406692
605	Ubiquitination	HTEELTSKEADLTEE CHHHHHHCCCCCCHH	52.25	-
624	Phosphorylation	LRSSVINSIREIKEE HHHHHHHHHHHHHHH	16.34	-
636	Ubiquitination	KEEIGNLKSSHSGVL HHHHCCCCCCCCCEE	54.64	-
637	Phosphorylation	EEIGNLKSSHSGVLE HHHCCCCCCCCCEEE	36.13	21406692
638	Phosphorylation	EIGNLKSSHSGVLEI HHCCCCCCCCCEEEE	21.78	21406692
640	Phosphorylation	GNLKSSHSGVLEIEN CCCCCCCCCEEEEEC	32.32	21406692
648	Phosphorylation	GVLEIENSVDDLSSR CEEEEECCHHHHHHH	17.71	21406692
653	Phosphorylation	ENSVDDLSSRMDILE ECCHHHHHHHHHHHH	23.92	21406692
654	Phosphorylation	NSVDDLSSRMDILEE CCHHHHHHHHHHHHH	38.63	23312004
665	Phosphorylation	ILEERIDSLEDQIEE HHHHHHHHHHHHHHH	31.15	14702039
675	Ubiquitination	DQIEEFSKDTMQMTK HHHHHHCHHHHHHHH	63.64	-
682	Ubiquitination	KDTMQMTKQIISKER HHHHHHHHHHHHHHH	33.87	-
686	Phosphorylation	QMTKQIISKERQRDI HHHHHHHHHHHHHHH	30.05	22617229
710	Ubiquitination	RLIGIPEKESYENRA EEECCCCHHHHCCHH	46.75	-
722	Ubiquitination	NRAEDIIKEIIDENF CHHHHHHHHHHHHCC	43.10	-
733	Ubiquitination	DENFAELKKGSSLEI HHCCHHHCCCCCCEE	46.74	16196087
734	Ubiquitination	ENFAELKKGSSLEIV HCCHHHCCCCCCEEE	76.33	-
736	Phosphorylation	FAELKKGSSLEIVSA CHHHCCCCCCEEEEE	40.40	21406692
737	Phosphorylation	AELKKGSSLEIVSAC HHHCCCCCCEEEEEC	38.39	21406692
742	Phosphorylation	GSSLEIVSACRVPSK CCCCEEEEECCCCCC	27.58	21406692
748	Phosphorylation	VSACRVPSKIDEKRL EEECCCCCCCCCCCC	39.11	21406692
756	O-linked_Glycosylation	KIDEKRLTPRHILVK CCCCCCCCCCEEEEE	23.47	30379171
767	Phosphorylation	ILVKFWNSSDKEKII EEEEECCCCCHHHHH	30.43	21406692
768	Phosphorylation	LVKFWNSSDKEKIIR EEEECCCCCHHHHHH	49.87	21406692
793	Phosphorylation	QGTRIRLTADLSLDT CCCEEEEEEEECCHH	14.31	29514088
797	Phosphorylation	IRLTADLSLDTLDAR EEEEEEECCHHHCHH	25.42	29514088
812	Ubiquitination	SKWSNVFKVLLEKGF HHHHHHHHHHHHCCC	27.91	-
817	Ubiquitination	VFKVLLEKGFNPRIL HHHHHHHCCCCCCCE	69.63	-
842	Phosphorylation	GKTKVFLSIEEFRDY CCEEEEEEHHHHHHH	19.25	21406692

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LITD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LITD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LITD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LN28A_HUMAN	LIN28A	physical	22162396
DHX9_HUMAN	DHX9	physical	22162396
KINH_HUMAN	KIF5B	physical	26496610
TCOF_HUMAN	TCOF1	physical	26496610
KAT6A_HUMAN	KAT6A	physical	26496610
CBX4_HUMAN	CBX4	physical	26496610
EIF3I_HUMAN	EIF3I	physical	26496610
TIF1B_HUMAN	TRIM28	physical	26496610
TARA_HUMAN	TRIOBP	physical	26496610
DCTN3_HUMAN	DCTN3	physical	26496610
RPA1_HUMAN	POLR1A	physical	26496610
PTHB1_HUMAN	BBS9	physical	26496610
RM04_HUMAN	MRPL4	physical	26496610
PP12C_HUMAN	PPP1R12C	physical	26496610
UACA_HUMAN	UACA	physical	26496610
IMP3_HUMAN	IMP3	physical	26496610
SEN34_HUMAN	TSEN34	physical	26496610
ZMYM1_HUMAN	ZMYM1	physical	26496610
BD1L1_HUMAN	BOD1L1	physical	26496610

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.