LIRB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LIRB1_HUMAN
• UniProt AC: Q8NHL6
• Protein Name: Leukocyte immunoglobulin-like receptor subfamily B member 1
• Gene Name: LILRB1
• Organism: Homo sapiens (Human).
• Sequence Length: 650
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .; Isoform 5: Secreted .
• Protein Description: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions..
• Protein Sequence: MTPILTVLICLGLSLGPRTHVQAGHLPKPTLWAEPGSVITQGSPVTLRCQGGQETQEYRLYREKKTALWITRIPQELVKKGQFPIPSITWEHAGRYRCYYGSDTAGRSESSDPLELVVTGAYIKPTLSAQPSPVVNSGGNVILQCDSQVAFDGFSLCKEGEDEHPQCLNSQPHARGSSRAIFSVGPVSPSRRWWYRCYAYDSNSPYEWSLPSDLLELLVLGVSKKPSLSVQPGPIVAPEETLTLQCGSDAGYNRFVLYKDGERDFLQLAGAQPQAGLSQANFTLGPVSRSYGGQYRCYGAHNLSSEWSAPSDPLDILIAGQFYDRVSLSVQPGPTVASGENVTLLCQSQGWMQTFLLTKEGAADDPWRLRSTYQSQKYQAEFPMGPVTSAHAGTYRCYGSQSSKPYLLTHPSDPLELVVSGPSGGPSSPTTGPTSTSGPEDQPLTPTGSDPQSGLGRHLGVVIGILVAVILLLLLLLLLFLILRHRRQGKHWTSTQRKADFQHPAGAVGPEPTDRGLQWRSSPAADAQEENLYAAVKHTQPEDGVEMDTRSPHDEDPQAVTYAEVKHSRPRREMASPPSPLSGEFLDTKDRQAEEDRQMDTEAAASEAPQDVTYAQLHSLTLRREATEPPPSQEGPSPAVPSIYATLAIH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	Nitration	GGQETQEYRLYREKK CCCCCCEEEEECCCC	8.97	-
99	Nitration	HAGRYRCYYGSDTAG ECCEEEEEECCCCCC	11.23	-
100	Nitration	AGRYRCYYGSDTAGR CCEEEEEECCCCCCC	17.49	-
122	Nitration	ELVVTGAYIKPTLSA EEEEECCEECCCCCC	15.72	-
252	Nitration	QCGSDAGYNRFVLYK EECCCCCCCEEEEEE	12.60	-
281	N-linked_Glycosylation	QAGLSQANFTLGPVS CCCCCCCCEEECCCC	23.85	UniProtKB CARBOHYD
302	N-linked_Glycosylation	YRCYGAHNLSSEWSA EEEECCCCCCCCCCC	40.87	UniProtKB CARBOHYD
341	N-linked_Glycosylation	PTVASGENVTLLCQS CEECCCCCEEEEEEC	35.28	UniProtKB CARBOHYD
378	Phosphorylation	STYQSQKYQAEFPMG CHHHHHEEEEECCCC	12.81	-
378	Nitration	STYQSQKYQAEFPMG CHHHHHEEEEECCCC	12.81	-
406	Nitration	GSQSSKPYLLTHPSD CCCCCCCEEEECCCC	20.34	-
521	Phosphorylation	DRGLQWRSSPAADAQ CCCCCCCCCCCCHHH	37.40	28450419
522 (in isoform 3)	Phosphorylation	-	15.24	24719451
522	Phosphorylation	RGLQWRSSPAADAQE CCCCCCCCCCCHHHH	15.24	26657352
523	Phosphorylation	GLQWRSSPAADAQEE CCCCCCCCCCHHHHH	32.48	27251275
533	Phosphorylation	DAQEENLYAAVKHTQ HHHHHCHHHHHHCCC	12.23	29978859
534	Phosphorylation	AQEENLYAAVKHTQP HHHHCHHHHHHCCCC	14.67	-
549 (in isoform 4)	Phosphorylation	-	31.56	30108239
550 (in isoform 3)	Phosphorylation	-	43.88	30108239
551	Phosphorylation	GVEMDTRSPHDEDPQ CCCCCCCCCCCCCCC	28.78	30108239
552 (in isoform 4)	Phosphorylation	-	35.34	30108239
553 (in isoform 3)	Phosphorylation	-	52.95	30108239
561	Phosphorylation	DEDPQAVTYAEVKHS CCCCCCCCCEEECCC	21.74	23532336
562 (in isoform 4)	Phosphorylation	-	8.31	29978859
562	Phosphorylation	EDPQAVTYAEVKHSR CCCCCCCCEEECCCC	8.31	29978859
563 (in isoform 4)	Phosphorylation	-	13.02	29978859
563 (in isoform 3)	Phosphorylation	-	13.02	29978859
563 (in isoform 2)	Phosphorylation	-	13.02	25587033
564 (in isoform 3)	Phosphorylation	-	41.50	29978859
564	Phosphorylation	PQAVTYAEVKHSRPR CCCCCCEEECCCCCC	41.50	-
576	Phosphorylation	RPRREMASPPSPLSG CCCCCCCCCCCCCCC	35.71	28450419
579	Phosphorylation	REMASPPSPLSGEFL CCCCCCCCCCCCCCC	41.69	28355574
581	Phosphorylation	MASPPSPLSGEFLDT CCCCCCCCCCCCCCH	13.91	20166139
582	Phosphorylation	ASPPSPLSGEFLDTK CCCCCCCCCCCCCHH	39.39	28450419
584	Phosphorylation	PPSPLSGEFLDTKDR CCCCCCCCCCCHHHH	39.39	-
588	Phosphorylation	LSGEFLDTKDRQAEE CCCCCCCHHHHHHHH	36.67	30108239
606	Phosphorylation	MDTEAAASEAPQDVT HCHHHHHHHCCCCCC	29.57	27486199
613	Phosphorylation	SEAPQDVTYAQLHSL HHCCCCCCHHHHHHH	22.79	28857561
614	Phosphorylation	EAPQDVTYAQLHSLT HCCCCCCHHHHHHHE	7.69	15474475
619	Phosphorylation	VTYAQLHSLTLRREA CCHHHHHHHEEEECC	31.48	28857561
621	Phosphorylation	YAQLHSLTLRREATE HHHHHHHEEEECCCC	22.64	28857561
644	Phosphorylation	SPAVPSIYATLAIH- CCCCCCEEEEECCC-	9.62	9285411

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	MARCHF9	Q86YJ5	PMID:19457934

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LIRB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LIRB1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
1A02_HUMAN	HLA-A	physical	12897781
1A03_HUMAN	HLA-A	physical	12897781
1A01_HUMAN	HLA-A	physical	12897781
1A26_HUMAN	HLA-A	physical	12897781
1B07_HUMAN	HLA-B	physical	12853576
1B18_HUMAN	HLA-B	physical	12853576
1C07_HUMAN	HLA-C	physical	12853576
HLAG_HUMAN	HLA-G	physical	12853576
HLAF_HUMAN	HLA-F	physical	11169396
PTN6_HUMAN	PTPN6	physical	9842885

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.