KIF1C_MOUSE - dbPTM
KIF1C_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KIF1C_MOUSE
UniProt AC O35071
Protein Name Kinesin-like protein KIF1C
Gene Name Kif1c
Organism Mus musculus (Mouse).
Sequence Length 1100
Subcellular Localization Cytoplasm, cytoskeleton .
Protein Description Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility (By similarity)..
Protein Sequence MAGASVKVAVRVRPFNARETSQDAKCVVSMQGNTTSIINPKQSKDAPKSFTFDYSYWSHTSVEDPQFASQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGRQEPGQQGIVPQLCEDLFSRVNVNQSAQLSYSVEVSYMEIYCERVRDLLNPKSRGSLRVREHPILGPYVQDLSKLAVTSYADIADLMDCGNKARTVAATNMNETSSRSHAVFTIVFTQRSHDQLTGLDSEKVSKISLVDLAGSERADSSGARGMRLKEGANINKSLTTLGKVISALADLQSKKRKSDFIPYRDSVLTWLLKENLGGNSRTAMIAALSPADINYEETLSTLRYADRTKQIRCNAVINEDPNARLIRELQEEVARLRDLLMAQGLSASALGGLKVEEGSPGGVLPPASSPPAPASPSSPPPHNGELEPSFSPSAEPQIGPEEAMERLQETEKIIAELNETWEEKLRKTEALRMEREALLAEMGVAVREDGGTVGVFSPKKTPHLVNLNEDPLMSECLLYHIKDGVTRVGQVDVDIKLTGQFIREQHCLFRSIPQPDGEVMVTLEPCEGAETYVNGKLVTEPLVLKSGNRIVMGKNHVFRFNHPEQARLERERGVPPPPGPPSEPVDWNFAQKELLEQQGIDIKLEMEKRLQDLENQYRKEKEEADLLLEQQRLYADSDSGEDSDKRSCEESWRLISSLREQLPPTTVQNIVKRCGLPSSGKRRAPRRVYQIPQRRRLQGKDPRWATMADLKMQAVKEICYEVALADFRHGRAEIEALAALKMRELCRTYGKPEGPGDAWRAVARDVWDTVGEEEGCGGGGGGSEEGARGAEVEDLRAHIDKLTGILQEVKLQNSSKDRELQALRDRMLRMERVIPLTQDLEDDNDESGLVTWAPPEGPEAVEETVPNDHSPAVRPTSPPLSSWERVSRLMEEDPAFRRGRLRWLKQEQLRLQGLQGAGGRGGGLRRPPARFVPPHDCKLRFPFKSNPQHRESWPGMGSGEAPAPQPPEEVTVPPAPPNRRPPSPRRPHRSRRNSLDGGSRSRGGGSTQPEPQHLRPQKHNGYPQQPQPSPAQRPGPRYPPYTTPPRMRRQRSAPDLKESGAAV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
44AcetylationIINPKQSKDAPKSFT
EECCCCCCCCCCCEE		56.2523864654
162PhosphorylationRDLLNPKSRGSLRVR
HHHCCCCCCCCCEEC		43.0323737553
165PhosphorylationLNPKSRGSLRVREHP
CCCCCCCCCEECCCC		16.3423737553
182PhosphorylationGPYVQDLSKLAVTSY
CHHHHHHHHHHHCCH		33.6323737553
201AcetylationDLMDCGNKARTVAAT
HHHHCCHHHHHEEEC		25.2419852563
204PhosphorylationDCGNKARTVAATNMN
HCCHHHHHEEECCCC		21.2522817900
208PhosphorylationKARTVAATNMNETSS
HHHHEEECCCCCCCC		25.8419854140
214PhosphorylationATNMNETSSRSHAVF
ECCCCCCCCCCCEEE		19.9919854140
295PhosphorylationLQSKKRKSDFIPYRD
HHHHCCCCCCCCHHH		41.6122067460
338PhosphorylationNYEETLSTLRYADRT
CHHHHHHHHHHHHCC		20.54-
405PhosphorylationGGVLPPASSPPAPAS
CCCCCCCCCCCCCCC		49.5025338131
412PhosphorylationSSPPAPASPSSPPPH
CCCCCCCCCCCCCCC		25.0225338131
414PhosphorylationPPAPASPSSPPPHNG
CCCCCCCCCCCCCCC		53.6425338131
415PhosphorylationPAPASPSSPPPHNGE
CCCCCCCCCCCCCCC		44.8225338131
461UbiquitinationLNETWEEKLRKTEAL
HHHHHHHHHHHHHHH		41.92-
489PhosphorylationAVREDGGTVGVFSPK
EEEECCCEEEEECCC		21.4428066266
494PhosphorylationGGTVGVFSPKKTPHL
CCEEEEECCCCCCCC		33.1425619855
671PhosphorylationLLEQQRLYADSDSGE
HHHHHHHHCCCCCCC		15.5625168779
674PhosphorylationQQRLYADSDSGEDSD
HHHHHCCCCCCCCCC		26.0425521595
676PhosphorylationRLYADSDSGEDSDKR
HHHCCCCCCCCCCHH		48.2925521595
680PhosphorylationDSDSGEDSDKRSCEE
CCCCCCCCCHHHHHH		40.5025521595
684PhosphorylationGEDSDKRSCEESWRL
CCCCCHHHHHHHHHH		31.4623984901
688PhosphorylationDKRSCEESWRLISSL
CHHHHHHHHHHHHHH		8.6623984901
693PhosphorylationEESWRLISSLREQLP
HHHHHHHHHHHHHCC		28.1025159016
694PhosphorylationESWRLISSLREQLPP
HHHHHHHHHHHHCCC		25.1825159016
907PhosphorylationETVPNDHSPAVRPTS
HCCCCCCCCCCCCCC		19.8825338131
913PhosphorylationHSPAVRPTSPPLSSW
CCCCCCCCCCCCCHH		43.2129472430
914PhosphorylationSPAVRPTSPPLSSWE
CCCCCCCCCCCCHHH		27.4828066266
947DimethylationWLKQEQLRLQGLQGA
HHHHHHHHHCCCCCC		25.34-
947MethylationWLKQEQLRLQGLQGA
HHHHHHHHHCCCCCC		25.3454540665
957DimethylationGLQGAGGRGGGLRRP
CCCCCCCCCCCCCCC		39.40-
957MethylationGLQGAGGRGGGLRRP
CCCCCCCCCCCCCCC		39.4018958325
962MethylationGGRGGGLRRPPARFV
CCCCCCCCCCCCCCC		52.9424394675
962DimethylationGGRGGGLRRPPARFV
CCCCCCCCCCCCCCC		52.94-
982PhosphorylationKLRFPFKSNPQHRES
EEECCCCCCCCCCCC		54.8723684622
989PhosphorylationSNPQHRESWPGMGSG
CCCCCCCCCCCCCCC		38.2323684622
1020PhosphorylationPPNRRPPSPRRPHRS
CCCCCCCCCCCCCCC		33.4522817900
1027PhosphorylationSPRRPHRSRRNSLDG
CCCCCCCCCCCCCCC		32.3419367708
1029MethylationRRPHRSRRNSLDGGS
CCCCCCCCCCCCCCC		38.0330987741
1031PhosphorylationPHRSRRNSLDGGSRS
CCCCCCCCCCCCCCC		26.4825521595
1036PhosphorylationRNSLDGGSRSRGGGS
CCCCCCCCCCCCCCC		32.3925266776
1037MethylationNSLDGGSRSRGGGST
CCCCCCCCCCCCCCC		33.3830987747
1038PhosphorylationSLDGGSRSRGGGSTQ
CCCCCCCCCCCCCCC		36.6525266776
1039MethylationLDGGSRSRGGGSTQP
CCCCCCCCCCCCCCC		46.8224129315
1043PhosphorylationSRSRGGGSTQPEPQH
CCCCCCCCCCCCCCC		27.4325338131
1066PhosphorylationYPQQPQPSPAQRPGP
CCCCCCCCCCCCCCC		27.8523684622
1075PhosphorylationAQRPGPRYPPYTTPP
CCCCCCCCCCCCCCH		16.2229472430
1078PhosphorylationPGPRYPPYTTPPRMR
CCCCCCCCCCCHHHC		20.8126643407
1079PhosphorylationGPRYPPYTTPPRMRR
CCCCCCCCCCHHHCC		38.3026643407
1080PhosphorylationPRYPPYTTPPRMRRQ
CCCCCCCCCHHHCCC		26.0026824392
1089PhosphorylationPRMRRQRSAPDLKES
HHHCCCCCCCCHHHH		35.5027087446
1096PhosphorylationSAPDLKESGAAV---
CCCCHHHHCCCC---		31.9527149854
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KIF1C_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KIF1C_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KIF1C_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KIF1C_HUMANKIF1Cphysical
20360068
TCP4_HUMANSUB1physical
20360068
IF4A3_HUMANEIF4A3physical
20360068
ARF3_HUMANARF3physical
20360068
HNRPD_HUMANHNRNPDphysical
20360068
SSBP_HUMANSSBP1physical
20360068
CHTOP_HUMANCHTOPphysical
20360068
SAHH_HUMANAHCYphysical
20360068
ARF1_HUMANARF1physical
20360068
CCDC9_HUMANCCDC9physical
20360068
TR150_HUMANTHRAP3physical
20360068
THOC4_HUMANALYREFphysical
20360068
G3P_HUMANGAPDHphysical
26496610
ABLM1_HUMANABLIM1physical
26496610
ZN33A_HUMANZNF33Aphysical
26496610
ADNP2_HUMANADNP2physical
26496610
PLXA3_HUMANPLXNA3physical
26496610
DYHC2_HUMANDYNC2H1physical
26496610
SLX4_HUMANSLX4physical
26496610
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KIF1C_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-674; SER-676 ANDSER-1031, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-674; SER-676 ANDTHR-1080, AND MASS SPECTROMETRY.

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