| UniProt ID | KCJ10_HUMAN | |
|---|---|---|
| UniProt AC | P78508 | |
| Protein Name | ATP-sensitive inward rectifier potassium channel 10 | |
| Gene Name | KCNJ10 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 379 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein. Basolateral cell membrane . In kidney distal convoluted tubules, located in the basolateral membrane where it colocalizes with KCNJ16. |
|
| Protein Description | May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules.. | |
| Protein Sequence | MTSVAKVYYSQTTQTESRPLMGPGIRRRRVLTKDGRSNVRMEHIADKRFLYLKDLWTTFIDMQWRYKLLLFSATFAGTWFLFGVVWYLVAVAHGDLLELDPPANHTPCVVQVHTLTGAFLFSLESQTTIGYGFRYISEECPLAIVLLIAQLVLTTILEIFITGTFLAKIARPKKRAETIRFSQHAVVASHNGKPCLMIRVANMRKSLLIGCQVTGKLLQTHQTKEGENIRLNQVNVTFQVDTASDSPFLILPLTFYHVVDETSPLKDLPLRSGEGDFELVLILSGTVESTSATCQVRTSYLPEEILWGYEFTPAISLSASGKYIADFSLFDQVVKVASPSGLRDSTVRYGDPEKLKLEESLREQAEKEGSALSVRISNV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Ubiquitination | --MTSVAKVYYSQTT --CCCEEEEEEEECC | 30230243 | ||
| 8 | Phosphorylation | MTSVAKVYYSQTTQT CCCEEEEEEEECCCC | - | ||
| 9 | Phosphorylation | TSVAKVYYSQTTQTE CCEEEEEEEECCCCC | - | ||
| 32 | Phosphorylation | IRRRRVLTKDGRSNV CEEEEEECCCCCCCC | - | ||
| 57 | Phosphorylation | LYLKDLWTTFIDMQW EEEHHHHHHHHCHHH | 26657352 | ||
| 66 | Phosphorylation | FIDMQWRYKLLLFSA HHCHHHHHHHHHHCC | 26657352 | ||
| 154 | Phosphorylation | LIAQLVLTTILEIFI HHHHHHHHHHHHHHH | 22210691 | ||
| 155 | Phosphorylation | IAQLVLTTILEIFIT HHHHHHHHHHHHHHH | 22210691 | ||
| 182 | Phosphorylation | RAETIRFSQHAVVAS HHCEEEECCCEEEEC | 25338102 | ||
| 189 | Phosphorylation | SQHAVVASHNGKPCL CCCEEEECCCCEEEE | 25338102 | ||
| 205 | Ubiquitination | IRVANMRKSLLIGCQ EEEECCCHHHHEECE | 30230243 | ||
| 224 | Ubiquitination | LLQTHQTKEGENIRL HHHEECCCCCCCEEE | 30230243 | ||
| 263 | Phosphorylation | YHVVDETSPLKDLPL EEECCCCCCCCCCCC | 24719451 | ||
| 323 | Phosphorylation | SLSASGKYIADFSLF EECCCCCEEECHHHC | 22210691 | ||
| 335 | Ubiquitination | SLFDQVVKVASPSGL HHCCEEEECCCCCCC | 30230243 | ||
| 338 | Phosphorylation | DQVVKVASPSGLRDS CEEEECCCCCCCCCC | 22210691 | ||
| 340 | Phosphorylation | VVKVASPSGLRDSTV EEECCCCCCCCCCCC | 22210691 | ||
| 345 | Phosphorylation | SPSGLRDSTVRYGDP CCCCCCCCCCCCCCH | 28857561 | ||
| 354 | Ubiquitination | VRYGDPEKLKLEESL CCCCCHHHCCHHHHH | - | ||
| 356 | Ubiquitination | YGDPEKLKLEESLRE CCCHHHCCHHHHHHH | - | ||
| 367 | Ubiquitination | SLREQAEKEGSALSV HHHHHHHHHCCCEEE | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KCJ10_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KCJ10_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KCJ10_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| A4_HUMAN | APP | physical | 21832049 | |
| SIAH1_HUMAN | SIAH1 | physical | 25416956 | |
| HSP7C_HUMAN | HSPA8 | physical | 26186194 | |
| COPB2_HUMAN | COPB2 | physical | 26186194 | |
| SC24B_HUMAN | SEC24B | physical | 26186194 | |
| COPG1_HUMAN | COPG1 | physical | 26186194 | |
| SC23B_HUMAN | SEC23B | physical | 26186194 | |
| TTC1_HUMAN | TTC1 | physical | 26186194 | |
| YTHD1_HUMAN | YTHDF1 | physical | 26186194 | |
| TMED8_HUMAN | TMED8 | physical | 26186194 | |
| DYL1_HUMAN | DYNLL1 | physical | 26186194 | |
| SC24A_HUMAN | SEC24A | physical | 26186194 | |
| BAG1_HUMAN | BAG1 | physical | 26186194 | |
| AEDO_HUMAN | ADO | physical | 26186194 | |
| TMED8_HUMAN | TMED8 | physical | 28514442 | |
| COPG1_HUMAN | COPG1 | physical | 28514442 | |
| HSP7C_HUMAN | HSPA8 | physical | 28514442 | |
| BAG1_HUMAN | BAG1 | physical | 28514442 | |
| YTHD1_HUMAN | YTHDF1 | physical | 28514442 | |
| AEDO_HUMAN | ADO | physical | 28514442 | |
| HSP74_HUMAN | HSPA4 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
