| UniProt ID | INPP_HUMAN | |
|---|---|---|
| UniProt AC | P49441 | |
| Protein Name | Inositol polyphosphate 1-phosphatase | |
| Gene Name | INPP1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 399 | |
| Subcellular Localization | ||
| Protein Description | ||
| Protein Sequence | MSDILRELLCVSEKAANIARACRQQEALFQLLIEEKKEGEKNKKFAVDFKTLADVLVQEVIKQNMENKFPGLEKNIFGEESNEFTNDWGEKITLRLCSTEEETAELLSKVLNGNKVASEALARVVHQDVAFTDPTLDSTEINVPQDILGIWVDPIDSTYQYIKGSADIKSNQGIFPCGLQCVTILIGVYDIQTGVPLMGVINQPFVSRDPNTLRWKGQCYWGLSYMGTNMHSLQLTISRRNGSETHTGNTGSEAAFSPSFSAVISTSEKETIKAALSRVCGDRIFGAAGAGYKSLCVVQGLVDIYIFSEDTTFKWDSCAAHAILRAMGGGIVDLKECLERNPETGLDLPQLVYHVENEGAAGVDRWANKGGLIAYRSRKRLETFLSLLVQNLAPAETHT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 74 | Ubiquitination | NKFPGLEKNIFGEES HCCCCCCCCCCCCCC | 61.46 | - | |
| 81 | Phosphorylation | KNIFGEESNEFTNDW CCCCCCCCCCCCCCH | 37.04 | - | |
| 109 | Ubiquitination | ETAELLSKVLNGNKV HHHHHHHHHHCCCHH | 51.19 | - | |
| 243 | Phosphorylation | TISRRNGSETHTGNT EEEECCCCCCCCCCC | 42.76 | 26657352 | |
| 245 | Phosphorylation | SRRNGSETHTGNTGS EECCCCCCCCCCCCC | 26.83 | 26657352 | |
| 247 | Phosphorylation | RNGSETHTGNTGSEA CCCCCCCCCCCCCCC | 39.28 | 27251275 | |
| 250 | Phosphorylation | SETHTGNTGSEAAFS CCCCCCCCCCCCCCC | 43.35 | 27251275 | |
| 252 | Phosphorylation | THTGNTGSEAAFSPS CCCCCCCCCCCCCCC | 23.25 | 27251275 | |
| 265 | Phosphorylation | PSFSAVISTSEKETI CCEEEEECCCCHHHH | 21.20 | 24275569 | |
| 271 | Phosphorylation | ISTSEKETIKAALSR ECCCCHHHHHHHHHH | 38.55 | - | |
| 273 | Ubiquitination | TSEKETIKAALSRVC CCCHHHHHHHHHHHH | 34.72 | - | |
| 283 | Methylation | LSRVCGDRIFGAAGA HHHHHCHHHHCCCCC | 16.06 | 115480355 | |
| 317 | Phosphorylation | DTTFKWDSCAAHAIL CCCCCCHHHHHHHHH | 12.44 | 18220336 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of INPP_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of INPP_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of INPP_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| DYL1_HUMAN | DYNLL1 | physical | 21900206 | |
| WDR12_HUMAN | WDR12 | physical | 22939629 | |
| TLK1_HUMAN | TLK1 | physical | 22939629 | |
| SYCE3_HUMAN | SYCE3 | physical | 24722188 | |
| CI016_HUMAN | C9orf16 | physical | 24722188 | |
| LDOC1_HUMAN | LDOC1 | physical | 24722188 | |
| MEOX2_HUMAN | MEOX2 | physical | 24722188 | |
| NDC80_HUMAN | NDC80 | physical | 24722188 | |
| NECA2_HUMAN | NECAB2 | physical | 24722188 | |
| NR1D1_HUMAN | NR1D1 | physical | 24722188 | |
| USBP1_HUMAN | USHBP1 | physical | 24722188 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-317, AND MASSSPECTROMETRY. | |
