IIGP5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IIGP5_HUMAN
• UniProt AC: Q6NXR0
• Protein Name: Interferon-inducible GTPase 5
• Gene Name: IRGC
• Organism: Homo sapiens (Human).
• Sequence Length: 463
• Protein Sequence: MATSKLPVVPGEEENTILMAKERLEALRTAFESGDLPQAASHLQELLASTESIRLEVGVTGESGAGKSSLINALRGLEAEDPGAALTGVMETTMQPSPYPHPQFPDVTLWDLPGAGSPGCPADKYLKQVDFSRYDFFLLVSPRRCGAVETRLAAEILCQGKKFYFVRTKVDEDLAATRTQRPSGFREAAVLQEIRDHCAERLREAGVADPRIFLVSNLSPARYDFPTLVSTWEHDLPSHRRHAGLLSLPDISLEALQKKKAMLQEQVLKTALVLGVIQALPVPGLAAAYDDALLIHSLRGYHRSFGLDDDSLAKLAEQVGKQAGDLRSVIRSPLANEVSPETVLRLYSQSSDGAMRVARAFERGIPVFGTLVAGGISFGAVYTMLQGCLNEMAEDAQRVRIKALEDDEPQPEVSLEVASDNGVEKGGSGEGGGEEAPLSTCRKLGLLLKYILDSWKKHDSEEK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Phosphorylation	GDLPQAASHLQELLA CCHHHHHHHHHHHHH	27.96	25693802
49	Phosphorylation	HLQELLASTESIRLE HHHHHHHCCCCEEEE	32.45	25693802
50	Phosphorylation	LQELLASTESIRLEV HHHHHHCCCCEEEEE	28.30	25693802
52	Phosphorylation	ELLASTESIRLEVGV HHHHCCCCEEEEEEC	17.07	25693802
60	Phosphorylation	IRLEVGVTGESGAGK EEEEEECCCCCCCCH	29.33	25693802
63	Phosphorylation	EVGVTGESGAGKSSL EEECCCCCCCCHHHH	34.98	25693802
68	Phosphorylation	GESGAGKSSLINALR CCCCCCHHHHHHHHC	29.47	25693802
69	Phosphorylation	ESGAGKSSLINALRG CCCCCHHHHHHHHCC	36.43	25693802
168	Phosphorylation	KKFYFVRTKVDEDLA CCEEEEEEECCHHHH	30.07	-
247	Phosphorylation	RRHAGLLSLPDISLE HCCCCHHCCCCCCHH	42.79	30622161
252	Phosphorylation	LLSLPDISLEALQKK HHCCCCCCHHHHHHH	27.77	30622161
289	Phosphorylation	VPGLAAAYDDALLIH CCCHHHHHCHHHHHH	15.05	22210691
297	Phosphorylation	DDALLIHSLRGYHRS CHHHHHHHHCCCHHH	16.87	22210691
304	Phosphorylation	SLRGYHRSFGLDDDS HHCCCHHHCCCCHHH	15.45	-
311	Phosphorylation	SFGLDDDSLAKLAEQ HCCCCHHHHHHHHHH	36.90	30622161
328	Phosphorylation	KQAGDLRSVIRSPLA HHHCCHHHHHHCCCC	29.24	25693802
332	Phosphorylation	DLRSVIRSPLANEVS CHHHHHHCCCCCCCC	17.09	25693802
350	Phosphorylation	VLRLYSQSSDGAMRV HHHHHHCCCHHHHHH	25.18	30622161
351	Phosphorylation	LRLYSQSSDGAMRVA HHHHHCCCHHHHHHH	32.21	30622161
414	Phosphorylation	DEPQPEVSLEVASDN CCCCCCEEEEEECCC	19.70	30622161
419	Phosphorylation	EVSLEVASDNGVEKG CEEEEEECCCCCCCC	36.46	30622161
428	Phosphorylation	NGVEKGGSGEGGGEE CCCCCCCCCCCCCCC	42.19	30622161

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IIGP5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IIGP5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IIGP5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
MET7B_HUMAN	METTL7B	physical	28514442
KS6A1_HUMAN	RPS6KA1	physical	28514442
FXL18_HUMAN	FBXL18	physical	28514442
P4K2A_HUMAN	PI4K2A	physical	28514442
RHOA_HUMAN	RHOA	physical	28514442
S26A6_HUMAN	SLC26A6	physical	28514442
AP3S1_HUMAN	AP3S1	physical	28514442
GDS1_HUMAN	RAP1GDS1	physical	28514442
MCU_HUMAN	MCU	physical	28514442
AT12A_HUMAN	ATP12A	physical	28514442
OMA1_HUMAN	OMA1	physical	28514442
KS6A3_HUMAN	RPS6KA3	physical	28514442
KS6A2_HUMAN	RPS6KA2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.