| UniProt ID | GIG1_ARATH | |
|---|---|---|
| UniProt AC | Q9M2R1 | |
| Protein Name | Protein GIGAS CELL1 | |
| Gene Name | GIG1 | |
| Organism | Arabidopsis thaliana (Mouse-ear cress). | |
| Sequence Length | 243 | |
| Subcellular Localization | ||
| Protein Description | Negative regulator of the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase required for proper mitotic and meiotic progression and cell fate determination. Involved in entry into both meiosis I and meiosis II. Prevents endomitosis by preferentially inhibiting APC/C(CDC20). Required for megagametophyte and endosperm development. Triggers mitotic cyclins (e.g. CYCB1-1 and CYCB1-2) accumulation. Confers immunity to bacterial pathogens (e.g. Pseudomonas syringae pv. tomato DC3000), which is associated with increased expression of disease resistance (R) genes. GIG1 and PANS1 are part of a network linking centromere cohesion and cell cycle progression through control of APC/C activity.. | |
| Protein Sequence | MPEARDRTERPVDYSTIFANRRRHGILLDEPDSRLSLIESPVNPDIGSIGGTGGLVRGNFTTWRPGNGRGGHTPFRLPQGRENMPIVTARRGRGGGLLPSWYPRTPLRDITHIVRAIERRRGAGTGGDDGRVIEIPTHRQVGVLESPVPLSGEHKCSMVTPGPSVGFKRSCPPSTAKVQKMLLDITKEIAEEEAGFITPEKKLLNSIDKVEKIVMAEIQKLKSTPQAKREEREKRVRTLMTMR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 36 | Phosphorylation | DEPDSRLSLIESPVN CCCCCCCHHEECCCC | 25368622 | ||
| 40 | Phosphorylation | SRLSLIESPVNPDIG CCCHHEECCCCCCCC | 25368622 | ||
| 48 | Phosphorylation | PVNPDIGSIGGTGGL CCCCCCCCCCCCCCE | 25368622 | ||
| 52 | Phosphorylation | DIGSIGGTGGLVRGN CCCCCCCCCCEEECC | 25368622 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GIG1_ARATH !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GIG1_ARATH !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GIG1_ARATH !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| APC10_ARATH | APC10 | physical | 20706207 | |
| CDC23_ARATH | APC8 | physical | 20706207 | |
| CD27B_ARATH | HBT | physical | 20706207 | |
| APC1_ARATH | EMB2771 | physical | 20706207 | |
| APC4_ARATH | AT4G21530 | physical | 20706207 | |
| APC5_ARATH | AT1G06590 | physical | 20706207 | |
| APC7_ARATH | AT2G39090 | physical | 20706207 | |
| CDC16_ARATH | APC6 | physical | 20706207 | |
| PSMD6_ARATH | AT4G24820 | physical | 20706207 | |
| CD27A_ARATH | CDC27a | physical | 20706207 | |
| RH9_ARATH | PMH1 | physical | 20706207 | |
| CDC21_ARATH | CDC20.1 | physical | 22167058 | |
| FZR2_ARATH | FZR2 | physical | 22167058 | |
| FZR3_ARATH | FZR3 | physical | 22167058 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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