dbPTM

FZR2_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FZR2_ARATH
UniProt AC	Q8L3Z8
Protein Name	Protein FIZZY-RELATED 2
Gene Name	FZR2
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	483
Subcellular Localization	Nucleus .
Protein Description	Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C). Necessary and sufficient for endoreduplication and correct cell expansion. Controls meristem size by stimulating endoreduplication in the elongation zone..
Protein Sequence	MEEEDPTASNVITNSNSSSMRNLSPAMNTPVVSLESRINRLINANQSQSPSPSSLSRSIYSDRFIPSRSGSNFALFDLSPSPSKDGKEDGAGSYATLLRAAMFGPETPEKRDITGFSSSRNIFRFKTETHRSLNSFSPFGVDDDSPGVSHSGPVKAPRKVPRSPYKVLDAPALQDDFYLNLVDWSAQNVLAVGLGNCVYLWNACSSKVTKLCDLGAEDSVCSVGWALRGTHLAVGTSTGKVQIWDASRCKRTRTMEGHRLRVGALAWGSSVLSSGSRDKSILQRDIRCQEDHVSKLAGHKSEVCGLKWSYDNRELASGGNDNRLFVWNQHSTQPVLKYSEHTAAVKAIAWSPHVHGLLASGGGTADRCIRFWNTTTNTHLSSIDTCSQVCNLAWSKNVNELVSTHGYSQNQIIVWKYPTMSKIATLTGHTYRVLYLAVSPDGQTIVTGAGDETLRFWNVFPSPKSQNTDSEIGSSFFGRTTIR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
58	Phosphorylation	SPSSLSRSIYSDRFI CCCHHHHHHHCCCCC	23.62	19880383
60	Phosphorylation	SSLSRSIYSDRFIPS CHHHHHHHCCCCCCC	13.03	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of FZR2_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FZR2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FZR2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APC4_SCHPO	cut20	physical	15970679
CDKA1_ARATH	CDC2	physical	15970679
CDC23_ARATH	APC8	physical	20706207
APC1_ARATH	EMB2771	physical	20706207
APC4_ARATH	AT4G21530	physical	20706207
APC5_ARATH	AT1G06590	physical	20706207
IF2B_ARATH	EIF2 BETA	physical	20706207
TCPA_ARATH	TCP-1	physical	20706207
APC2_ARATH	APC2	physical	20706207
APC7_ARATH	AT2G39090	physical	20706207
CD27B_ARATH	HBT	physical	20706207
PSMD6_ARATH	AT4G24820	physical	20706207
EF115_ARATH	AT5G07310	physical	20706207
COB22_ARATH	AT1G52360	physical	20706207
EIF3C_ARATH	EIF3C	physical	20706207
THO4B_ARATH	AT5G02530	physical	20706207
C3H24_ARATH	AT2G28450	physical	20706207

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FZR2_ARATH

Related Literatures of Post-Translational Modification