CD27B_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CD27B_ARATH
• UniProt AC: Q8LGU6
• Protein Name: Cell division cycle protein 27 homolog B
• Gene Name: CDC27B
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 744
• Subcellular Localization: Nucleus .
• Protein Description: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex controls several key steps in the cell cycle by mediating ubiquitination and subsequent degradation of target proteins such as cyclins. The APC/C complex is required for the female gametophyte development and is involved in several aspect of development by controlling cell division and cell elongation. Involved in the control of endoreduplication. Functionally redundant with CDC27A in the control of gametophyte development..
• Protein Sequence: MEAMLVDCVNNSLRHFVYKNAIFMCERLCAEFPSEVNLQLLATSYLQNNQAYSAYHLLKGTQMAQSRYLFALSCFQMDLLNEAESALCPVNEPGAEIPNGAAGHYLLGLIYKYTDRRKNAAQQFKQSLTIDPLLWAAYEELCILGAAEEATAVFGETAALSIQKQYMQQLSTSLGLNTYNEERNSTSTKNTSSEDYSPRQSKHTQSHGLKDISGNFHSHGVNGGVSNMSFYNTPSPVAAQLSGIAPPPLFRNFQPAVANPNSLITDSSPKSTVNSTLQAPRRKFVDEGKLRKISGRLFSDSGPRRSSRLSADSGANINSSVATVSGNVNNASKYLGGSKLSSLALRSVTLRKGHSWANENMDEGVRGEPFDDSRPNTASTTGSMASNDQEDETMSIGGIAMSSQTITIGVSEILNLLRTLGEGCRLSYMYRCQEALDTYMKLPHKHYNTGWVLSQVGKAYFELIDYLEAEKAFRLARLASPYCLEGMDIYSTVLYHLKEDMKLSYLAQELISTDRLAPQSWCAMGNCYSLQKDHETALKNFLRAVQLNPRFAYAHTLCGHEYTTLEDFENGMKSYQNALRVDTRHYNAWYGLGMIYLRQEKLEFSEHHFRMAFLINPSSSVIMSYLGTSLHALKRSEEALEIMEQAIVADRKNPLPMYQKANILVCLERLDEALEVLEELKEYAPSESSVYALMGRIYKRRNMHDKAMLHFGLALDMKPPATDVAAIKAAMEKLHVPDEIDESP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
197	Phosphorylation	NTSSEDYSPRQSKHT CCCCCCCCCCCCCCC	26.40	25561503
299	Phosphorylation	KISGRLFSDSGPRRS EECCCCCCCCCCCCC	35.14	25561503
301	Phosphorylation	SGRLFSDSGPRRSSR CCCCCCCCCCCCCCC	49.88	25561503
743	Phosphorylation	VPDEIDESP------ CCCCCCCCC------	31.96	30291188

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CD27B_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CD27B_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CD27B_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDC23_ARATH	APC8	physical	20706207
CDC16_ARATH	APC6	physical	20706207
PYM_ARATH	UVI4	physical	20706207
APC1_ARATH	EMB2771	physical	20706207
APC4_ARATH	AT4G21530	physical	20706207
APC5_ARATH	AT1G06590	physical	20706207
APC7_ARATH	AT2G39090	physical	20706207
TPIS_ARATH	TPI	physical	20706207

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.