TCPA_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TCPA_ARATH
• UniProt AC: P28769
• Protein Name: T-complex protein 1 subunit alpha {ECO:0000303|PubMed:11599560}
• Gene Name: CCT1 {ECO:0000305}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 545
• Subcellular Localization: Cytoplasm .
• Protein Description: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin..
• Protein Sequence: MSISAQNPDISGDRQSGQDVRTQNVMACQAVSNIVKTSLGPVGLDKMLVDDIGDVTITNDGATILRMLEVEHPAAKVLVELAELQDREVGDGTTSVVIVAAELLKRANDLVRNKIHPTSIISGYRLAMRESCKYIEEKLVTKVEKLGKVPLINCAKTSMSSKLISGDSDFFANLVVEAVLSVKMTNQRGEIKYPIKGINILKAHGQSARDSYLLNGYALNTGRAAQGMPLRVSPAKIACLDFNLQKTKMQLGVQVVVNDPRELEKIRQREADMTKERIEKLLKAGANVILTTKGIDDMALKYFVEAGAIAVRRVRKEDMRHVAKATGATLVTTFADMEGEETFDPAHLGSADEVVEERIADDDVILIKGTKTSSAVSLILRGANDYMLDEMERALHDALCIVKRTLESNTVVAGGGAVESALSVYLEHLATTLGSREQLAIAEFADALLIIPKVLAVNAAKDATELVAKLRAYHHTAQTKADKKHYSSMGLDLVNGTIRNNLEAGVIEPAMSKVKIIQFATEAAITILRIDDMIKLVKDESQGEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSISAQNPD ------CCCCCCCCC	25.83	22223895
2	Phosphorylation	------MSISAQNPD ------CCCCCCCCC	25.83	30407730
4	Phosphorylation	----MSISAQNPDIS ----CCCCCCCCCCC	19.25	29654922
32	Phosphorylation	VMACQAVSNIVKTSL HHHHHHHHHHHHHCC	24.69	28295753
521	Phosphorylation	VKIIQFATEAAITIL CHHHHHHHHHHHHHH	27.69	25368622
526	Phosphorylation	FATEAAITILRIDDM HHHHHHHHHHHHHHH	14.83	25368622
541	Phosphorylation	IKLVKDESQGEE--- HHHHHCHHCCCC---	54.33	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TCPA_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TCPA_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TCPA_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COP1_ARATH	COP1	physical	11752373

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.