dbPTM

COB22_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	COB22_ARATH
UniProt AC	Q9C827
Protein Name	Coatomer subunit beta'-2
Gene Name	At1g52360
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	926
Subcellular Localization	Cytoplasm. Golgi apparatus membrane Peripheral membrane protein Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane Peripheral membrane protein Cytoplasmic side. The coatomer is cytoplasmic or polymerized on the cytoplasmic side o
Protein Description	The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity)..
Protein Sequence	MPLRLEIKRKLAQRSERVKSVDLHPTEPWILASLYSGTLCIWNYQTQVMAKSFEVTELPVRSAKFVARKQWVVAGADDMYIRVYNYNTMDKVKVFEAHSDYIRCVAVHPTLPYVLSSSDDMLIKLWDWEKGWACTQIFEGHSHYVMQVTFNPKDTNTFASASLDRTIKIWNLGSPDPNFTLDAHQKGVNCVDYFTGGDKPYLITGSDDHTAKVWDYQTKSCVQTLEGHTHNVSAVCFHPELPIIITGSEDGTVRIWHATTYRLENTLNYGLERVWAIGYIKSSRRVVIGYDEGTIMVKLGREIPVASMDNTGKIIWAKHNEIQTANIKSIGADYEVTDGERLPLSVKELGTCDLYPQSLKHNPNGRFVVVCGDGEYIIYTALAWRNRSFGSGLEFVWSSEGECAVRESSSKIKIFSKNFQEKRSIRPTFSAEKIFGGTLLAMCSSDFICFYDWAECRLIQRIDVTVKNLYWADSGDLVAIASDTSFYILKFNRDLVTSHFDSGRPTEEEGVEDAFEVLHENDERVRTGIWVGDCFIYNNSSWKLNYCVGGEVTTMYHLDRPMYLLGYLASQSRVFLVDKEFNVIGYTLLLSLIEYKTLVMRGDLDKASEILPTIPKDQHNSVAHFLESRGMIEDALEIATDPDYRFELAIQLGRLEIAQEIAVEVQSESKWKQLGELAMSSGKLQMAEECMKYAMDLSGLLLLYSSLGDAEGVTKLATLAKEQGKNNVAFLCLFMLGKLEDCLQLLVESNRIPEAALMARSYLPSKVSEIVALWRKDLSKVNSKAAESLADPEEYSNLFEDWQVALSVEAKAVETRGVYTGAKDYPSHADKSSMTLVEAFRNLQVEEEESLENGDMDHEEVVAEENGNEQRNEDDVAEHVEEHHEEKEAEEEEGIVDGDSTDGAVLVNGSEADEEWGTNNEGNPSA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
308	Sulfoxidation	REIPVASMDNTGKII CCCCEEEECCCCCEE	3.12	23289948
416	Phosphorylation	SSKIKIFSKNFQEKR CCCEEEEECCHHHHC	30.11	19880383
850	Phosphorylation	LQVEEEESLENGDMD CCCCCHHHHHCCCCC	44.24	23776212
900	Phosphorylation	EGIVDGDSTDGAVLV CCCCCCCCCCCEEEE	33.65	23776212
901	Phosphorylation	GIVDGDSTDGAVLVN CCCCCCCCCCEEEEC	43.10	23776212
910	Phosphorylation	GAVLVNGSEADEEWG CEEEECCCCCCCCCC	25.14	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of COB22_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of COB22_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of COB22_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of COB22_ARATH !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of COB22_ARATH

Related Literatures of Post-Translational Modification